| Title: |
Maternal weight gain in excess of pregnancy guidelines is relatedtodaughters being overweight 40 years later |
| Authors: |
Houghton, LC; Ester, WA; Lumey, LH; Michels, KB; Wei, Y; Cohn, BA; Susser, ES; Terry, MB |
| Source: |
American Journal of Obstetrics and Gynecology, vol 215, iss 2 |
| Publisher Information: |
eScholarship, University of California |
| Publication Year: |
2016 |
| Collection: |
University of California: eScholarship |
| Subject Terms: |
3215 Reproductive Medicine (for-2020); 32 Biomedical and Clinical Sciences (for-2020); Childhood Obesity (rcdc); Maternal Health (rcdc); Pediatric (rcdc); Prevention (rcdc); Nutrition (rcdc); Contraception/Reproduction (rcdc); Obesity (rcdc); Pregnancy (rcdc); Clinical Research (rcdc); Women's Health (rcdc); Cancer (hrcs-hc); Metabolic and endocrine (hrcs-hc); Reproductive health and childbirth (hrcs-hc); Oral and gastrointestinal (hrcs-hc); 3 Good Health and Well Being (sdg); Adult (mesh); Body Mass Index (mesh); Female (mesh); Humans (mesh); Maternal Nutritional Physiological Phenomena (mesh); Mothers (mesh); Nuclear Family (mesh); Overweight (mesh); Pregnancy (mesh); Prenatal Exposure Delayed Effects (mesh); Risk Factors (mesh); Weight Gain (mesh); gestational weight gain |
| Subject Geographic: |
246.e1 - 246.e8 |
| Description: |
BACKGROUND: Exceeding the Institute of Medicine guidelines for pregnancy weight gain increases childhood and adolescent obesity. However, it is unknown if these effects extend to midlife. OBJECTIVE: We sought to determine if exceeding the Institute of Medicine guidelines for pregnancy weight gain increases risk of overweight/obesity in daughters 40 years later. STUDY DESIGN: This cohort study is based on adult offspring in the Child Health and Development Studies and the Collaborative Perinatal Project pregnancy cohorts originally enrolled in the 1960s. In 2005 through 2008, 1035 daughters in their 40s were recruited to the Early Determinants of Mammographic Density study. We classified maternal pregnancy weight gain as greater than vs less than or equal to the 2009 clinical guidelines. We used logistic regression to compare the odds ratios of daughters being overweight/obese (body mass index [BMI] ≥25) at a mean age of 44 years between mothers who did not gain or gained more than pregnancy weight gain guidelines, accounting for maternal prepregnant BMI, and daughter body size at birth and childhood. We also examined potential family related confounding through a comparison of sisters using generalized estimating equations, clustered on sibling units and adjusted for maternal age and race. RESULTS: Mothers who exceeded guidelines for weight gain in pregnancy were more likely to have daughters who were overweight/obese in their 40s (odds ratio [OR], 3.4; 95% confidence interval {CI}, 2.0-5.7). This magnitude of association translates to a relative risk (RR) increase of 50% (RR = 1.5; 95% CI, 1.3-1.6). The association was of the same magnitude when examining only the siblings whose mother exceeded guidelines in 1 pregnancy and did not exceed the guidelines in the other pregnancy. The association was stronger with increasing maternal prepregnancy BMI (P trend |
| Document Type: |
article in journal/newspaper |
| File Description: |
application/pdf |
| Language: |
unknown |
| Relation: |
qt17j751gg; https://escholarship.org/uc/item/17j751gg; https://escholarship.org/content/qt17j751gg/qt17j751gg.pdf |
| DOI: |
10.1016/j.ajog.2016.02.034 |
| Availability: |
https://escholarship.org/uc/item/17j751gg; https://escholarship.org/content/qt17j751gg/qt17j751gg.pdf; https://doi.org/10.1016/j.ajog.2016.02.034 |
| Rights: |
public |
| Accession Number: |
edsbas.A70D68D9 |
| Database: |
BASE |