| Title: |
The phenotypic and genotypic association of grip strength with frailty, physical performance and functional limitations over time in older adults |
| Authors: |
Stringa, Najada; van Schoor, Natasja M.; Hoogendijk, Emiel O.; Milaneschi, Yuri; Huisman, Martijn |
| Source: |
Stringa, N, van Schoor, N M, Hoogendijk, E O, Milaneschi, Y & Huisman, M 2023, 'The phenotypic and genotypic association of grip strength with frailty, physical performance and functional limitations over time in older adults', Age and Ageing, vol. 52, no. 10, afad189. https://doi.org/10.1093/ageing/afad189 |
| Publication Year: |
2023 |
| Description: |
Objectives: To replicate the phenotypic associations of grip strength with frailty, physical performance and functional limitations in older adults for longer follow-up periods and to examine whether these associations are due to shared genetic factors. Methods: In total 2,262 participants 55 years and older with follow-up data up to 23 years (Nobservations = 8,262) from the Longitudinal Aging Study Amsterdam were included. Weighted polygenic risk scores for grip strength (PRS-GS) were built using the genome-wide meta-analysis results from UK Biobank as reference. Grip strength was measured two times on each hand using a dynamometer. Frailty index (FI) and frailty phenotype were operationalised following standard procedures. Performance tests included a timed walk test, a repeated chair stands test and put on-take off cardigan test. Functional limitations were assessed using a questionnaire with six items. Results: Higher grip strength was phenotypically associated with lower FI (b = -0.013, 95% CI (-0.016, -0.009)), better physical performance (b = 0.040, 95% CI (0.026, 0.054)) and less functional limitations (OR = 0.965, 95% CI (0.954, 0.977)) over time for follow-up periods up to 23 years. However, PRS-GS was not associated with any of the traits. Conclusion: The phenotypic associations between grip strength, frailty, physical performance and functional limitations were replicated for follow-up periods up to 23 years. However, the associations between the traits could not be explained by shared genetics potentially indicating a more relevant involvement of non-genetic factors. |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| ISSN: |
0002-0729; 1468-2834 |
| Relation: |
info:eu-repo/semantics/altIdentifier/pmid/37847794; info:eu-repo/semantics/altIdentifier/pissn/0002-0729; info:eu-repo/semantics/altIdentifier/eissn/1468-2834 |
| DOI: |
10.1093/ageing/afad189 |
| Availability: |
https://research.vumc.nl/en/publications/6d739f7e-758d-4de3-ad4e-26209bd6eab5; https://doi.org/10.1093/ageing/afad189; https://www.scopus.com/pages/publications/85175534677 |
| Rights: |
info:eu-repo/semantics/openAccess |
| Accession Number: |
edsbas.A75F89DF |
| Database: |
BASE |