| Title: |
Development and Evaluation of the Magnetic Properties of a New Manganese (II) Complex: A Potential MRI Contrast Agent |
| Authors: |
Reale G.; Calderoni F.; Ghirardi T.; Porto F.; Illuminati F.; Marvelli L.; Martini P.; Uccelli L.; Tonini E.; Del Bianco L.; Spizzo F.; Capozza M.; Cazzola E.; Carnevale A.; Giganti M.; Turra A.; Esposito J.; Boschi A. |
| Contributors: |
Reale, G.; Calderoni, F.; Ghirardi, T.; Porto, F.; Illuminati, F.; Marvelli, L.; Martini, P.; Uccelli, L.; Tonini, E.; Del Bianco, L.; Spizzo, F.; Capozza, M.; Cazzola, E.; Carnevale, A.; Giganti, M.; Turra, A.; Esposito, J.; Boschi, A. |
| Publication Year: |
2023 |
| Collection: |
Università degli Studi di Ferrara: CINECA IRIS |
| Subject Terms: |
dithiocarbamate; magnetic resonance imaging; manganese |
| Description: |
Magnetic resonance imaging (MRI) is a non-invasive powerful modern clinical technique that is extensively used for the high-resolution imaging of soft tissues. To obtain high-definition pictures of tissues or of the whole organism this technique is enhanced by the use of contrast agents. Gadolinium-based contrast agents have an excellent safety profile. However, over the last two decades, some specific concerns have surfaced. Mn(II) has different favorable physicochemical characteristics and a good toxicity profile, which makes it a good alternative to the Gd(III)-based MRI contrast agents currently used in clinics. Mn(II)-disubstituted symmetrical complexes containing dithiocarbamates ligands were prepared under a nitrogen atmosphere. The magnetic measurements on Mn complexes were carried out with MRI phantom measurements at 1.5 T with a clinical magnetic resonance. Relaxivity values, contrast, and stability were evaluated by appropriate sequences. Studies conducted to evaluate the properties of paramagnetic imaging in water using a clinical magnetic resonance showed that the contrast, produced by the complex [Mn(II)(L’)2] × 2H2O (L’ = 1.4-dioxa-8-azaspiro[4.5]decane-8-carbodithioate), is comparable to that produced by gadolinium complexes currently used in medicine as a paramagnetic contrast agent. |
| Document Type: |
article in journal/newspaper |
| File Description: |
STAMPA |
| Language: |
English |
| Relation: |
info:eu-repo/semantics/altIdentifier/pmid/36834877; info:eu-repo/semantics/altIdentifier/wos/WOS:000939029400001; volume:24; issue:4; firstpage:3461-1; lastpage:3461-12; numberofpages:12; journal:INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES; https://hdl.handle.net/11392/2505050 |
| DOI: |
10.3390/ijms24043461 |
| Availability: |
https://hdl.handle.net/11392/2505050; https://doi.org/10.3390/ijms24043461; https://www.mdpi.com/1422-0067/24/4/3461 |
| Rights: |
info:eu-repo/semantics/openAccess ; license:Creative commons ; license uri:http://creativecommons.org/licenses/by/4.0/ |
| Accession Number: |
edsbas.A76980EB |
| Database: |
BASE |