| Title: |
Malignant Transformation of Giant Cell Tumour of Bone: A Review of Literature and the Experience of a Referral Centre |
| Authors: |
Sabrina Vari; Federica Riva; Concetta Elisa Onesti; Antonella Cosimati; Davide Renna; Roberto Biagini; Jacopo Baldi; Carmine Zoccali; Vincenzo Anelli; Alessio Annovazzi; Renato Covello; Andrea Ascione; Beatrice Casini; Virginia Ferraresi |
| Source: |
International Journal of Molecular Sciences, Vol 23, Iss 10721, p 10721 (2022) |
| Publisher Information: |
MDPI AG |
| Publication Year: |
2022 |
| Collection: |
Directory of Open Access Journals: DOAJ Articles |
| Subject Terms: |
giant cell tumour of bone; bone sarcoma; denosumab; radiological features; diagnosis; malignant transformation; Biology (General); QH301-705.5; Chemistry; QD1-999 |
| Description: |
Giant cell tumour of bone (GCTB) is a benign, locally aggressive primary bone neoplasm that represents 5% of all bone tumours. The principal treatment approach is surgery. Although generally GCTB is considered only a locally aggressive disease, it can metastasise, and lung metastases occur in 1–9% of patients. To date, only the use of denosumab has been approved as medical treatment for GCTB. Even more rarely, GCTB undergoes sarcomatous transformation into a malignant tumour (4% of all GCTB), but history of this malignant transformation is unclear and unpredictable. Considering the rarity of the event, the data in the literature are few. In this review, we summarise published data of GCTB malignant transformation and we analyse three cases of malignant transformation of GCTB, evaluating histopathology, genetics, and radiological aspects. Despite the rarity of this event, we conclude that a strict follow up is recommended to detect early malignant transformation. |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| Relation: |
https://www.mdpi.com/1422-0067/23/18/10721; https://doaj.org/toc/1661-6596; https://doaj.org/toc/1422-0067; https://doaj.org/article/64997c56111a476597466854b9da6161 |
| DOI: |
10.3390/ijms231810721 |
| Availability: |
https://doi.org/10.3390/ijms231810721; https://doaj.org/article/64997c56111a476597466854b9da6161 |
| Accession Number: |
edsbas.A79F52F8 |
| Database: |
BASE |