| Title: |
Clinical characteristics, management and outcomes of enterococcal infective endocarditis: an ancillary study from the ESC-EORP EURO-ENDO registry |
| Authors: |
Philip, Mary; Dumonceau, Robinson Gravier; Citro, Rodolfo; Cosyns, Bernard; Donal, Erwan; Erba, Paola Anna; Gouriet, Frédérique; Iung, Bernard; Kong, William; Lancellotti, Patrizio; Maggioni, Aldo; Mancini, Julien; Popescu, Bogdan; Prendergast, Bernard; Sambola, Antonia; Sengupta, Shantanu; Timoteo, Ana; Tribouilloy, Christophe; van Melle, Joost; Giorgi, Roch; Habib, Gilbert; Ferrari, R; Alonso, A; Bax, J; Blomström-Lundqvist, C; Gielen, S; Lancellotti, P; Maggioni, A; Maniadakis, N; Pinto, F; Ruschitzka, F; Tavazzi, L; Vardas, P; Weidinger, F; Zeymer, U; Vahanian, A; Budaj, A; Dagres, N; Danchin, N; Delgado, V; Emberson, J; Friberg, O; Gale, C; Heyndrickx, G; Iung, B; James, S; Kappetein, A; Nagy, K; Parati, G; Petronio, A-S; Pietila, M; Prescott, E; van de Werf, F; Erba, Paola; Tornos, Pilar; Tatar-Chentir, Nora Nabila Ali; Al-Mallah, Mouaz; Aneq, Meriam Astrom; Athanassopoulos, George; Badano, Luigi Paolo; Benyoussef, Soraya; Aranda, Erick Calderon; Cardim, Nuno Miguel; Chan, Kwan-Leung; Cruz, Ines; Edvardsen, Thor; Goliasch, Georg; Hagendorff, Andreas; Hristova, Krasimira; Kamp, Otto; Kang, Duk-Hyun; Matskeplishvili, Simon; Meshaal, Marwa; Mirocevic, Maja; Neskovic, Aleksandar; Pazdernik, Michal; Plonska-Gosciniak, Edyta; Raissouni, Maha; Ronderos, Ricardo; Sade, Leyla Elif; Sadeghpour, Anita; Separovic-Hanzevacki, Jadranka; Takeuchi, Masaaki; Tucay, Edwin; Rodrigues, Ana Clara Tude; Varga, Albert; Vaskelyte, Jolanta; Yamagata, Kentaro; Yiangou, Kyriakos; Zaky, Hosam; Ronderos, R; Avegliano, G; Fernandez Oses, P; Filipini, E; Granada, I; Iribarren, A; Mahia, M; Nacinovich, F; Ressi, S; Obregon, R; Bangher, M; Dho, J; Cartasegna, L; Plastino, M; Novas, V; Shigel, C; Reyes, G; de Santos, M; Gastaldello, N; Granillo Fernandez, M; Potito, M; Streitenberger, G; Velazco, P; Casabé, J; Cortes, C; Guevara, E; Salmo, F; Seijo, M; Heger, M; Brooks, R; Stöllberger, C; Ho, C-Y; Perschy, L; Puskas, L; Goliasch, G; Binder, C; Rosenhek, R; Schneider, M; Winter, M-P; Hoffer, E; Melissopoulou, M; Lecoq, E; Legrand, D; Jacquet, S; Massoz, M; Pierard, L; Dulgheru, R; Marchetta, S; D´emal, C; Oury, C; Cosyns, B; Droogmans, S; Kerkhove, D; Motoc, A; Plein, D; Roosens, B; Soens, L; Weytjens, C; Lemoine, I; Rodrigus, I; Paelinck, B; Amsel, B; Unger, P; Konopnicki, D; Beauloye, C; Pasquet, A; Pierard, S; Vancraeynest, D; Vanoverschelde, J; Sinnaeve, F; Andrade, J; Tude Rodrigues, A; Staszko, K; dos Santos Monteiro, R; Miglioranza, M; Shuha, D; Alcantara, M; Cravo, V; Fazzio, L; Felix, A; Iso, M; Musa, C; Siciliano, A; Villaca Filho, F; Braga, J; Rodrigues, A; Silva, R; Vilela, F; Rodrigues, D; Silva, L; Morhy, S; Fischer, C; Vieira, M; Afonso, T; Abreu, J; Falcao, S; Moises, V; Gouvea, A; João, G; Mancuso, F; Silva, C; Souza, A; Abboud, C; Bellio de Mattos Barretto, R; Ramos, A; Arnoni, R; Assef, J; Della Togna, D; Le Bihan, D; Miglioli, L; Romero Oliveira, A; Tadeu Magro Kroll, R; Cortez, D; Gelape, C; Peirira Nunes, M; de Abreu Ferrari, T; Chan, K-L; Hay, K; Le, V; Page, M; Poulin, F; Sauve, C; Serri, K; Mercure, C; Beaudoin, J; Pibarot, P; Sebag, I; Rudski, L; Ricafort, G; Barsic, B; Krajinovic, V; Vargovic, M; Separovic-Hanzevacki, J; Lovric, D; Reskovic-Luksic, V; Vincelj, J; Jaksic Jurinjak, S; Yiannikourides, V; Ioannides, M; Kyriakou, C; Pofaides, C; Masoura, V; Yiangou, K; Pudich, J; Linhart, A; Siranec, M; Marek, J; Blechova, K; Kamenik, M; Pazdernik, M; Pelouch, R; Coufal, Z; Mikulica, M; Griva, M; Jancova, E; Mikulcova, M; Taborsky, M; Precek, J; Jecmenova, M; Latal, J; Widimsky, J; Butta, T; Machacek, S; Vancata, R; Spinar, J; Holicka, M; Pow Chon Long, F; Anzules, N; Bajana Carpio, A; Largacha, G; Penaherrera, E; Moreira, D; Mahfouz, E; Elsafty, E; Soliman, A; Zayed, Y; Aboulenein, J; Abdel-Hay, M; Almaghraby, A; Abdelnaby, M; Ahmed, M; Hammad, B; Saleh, Y; Zahran, H; Elgebaly, O; Saad, A; Ali, M; Zeid, A; El Sharkawy, R; Meshaal, M; Al Kholy, A; Doss, R; Osama, D; Rizk, H; Elmogy, A; Mishriky, M; Assayag, P; El Hatimi, S; Botelho-Nevers, E; Campisi, S; Fuzellier, J-F; Gagneux-Brunon, A; Pierrard, R; Tulane, C; Detoc, M; Mehalla, T; Boutoille, D; Al Habash, O; Asseray-Madani, N; Biron, C; Brochard, J; Caillon, J; Cueff, C; Le Tourneau, T; Lecompte, A; Lecomte, R; Lefebvre, M; Magali Michel, M; Pattier, S; Delarue, S; Le Bras, M; Orain, J; Faucher, J-F; Aboyans, V; Beeharry, A; Durox, H; Lacoste, M; Magne, J; Mohty, D; David, A; Pradel, V; Sierra, V; Neykova, A; Bettayeb, B; Elkentaoui, S; Tzvetkov, B; Landry, G; Strady, C; Ainine, K; Baumard, S; Brasselet, C; Tassigny, C; Valente-Pires, V; Lefranc, M; Hoen, B; Lefevre, B; Curlier, E; Callier, C; Fourcade, N; Jobic, Y; Ansard, S; Le Berre, R; Le Roux, P; Le Ven, F; Pouliquen, M-C; Prat, G; Bouchart, F; Savoure, A; Alarcon, C; Chapuzet, C; Gueit, I; Bohbot, Y; Peugnet, F; Gun, M; Duval, X; Lescure, X; Ilic-Habensus, E; Sadoul, N; Selton-Suty, C; Alla, F; Chevalier, E; Goehringer, F; Huttin, O; Garcia, R; Le Marcis, V; Tattevin, P; Donal, E; Flecher, E; Revest, M; Habib, G; Hubert, S; Casalta, J-P; Gouriet, F; Arregle, F; Cammilleri, S; Tessonnier, L; Riberi, A; Chirouze, C; Bouiller, K; Brunel, A-S; Fournier, D; Hustache-Mathieu, L; Klopfenstein, T; Moreau, J; Lim, P; Oliver, L; Ternacle, J; Moussafeur, A; Chavanet, P; Piroth, L; Buisson, M; Mahy, S; Martins, C; Salmon-Rousseau, A; Gohier, S; Piper, C; Börgermann, J; Guckel, D; Horstkotte, D; Brockmeier, B; Winkelmann, E; Hagendorff, A; Grey, D; Nickenig, G; Schueler, R; Öztürk, C; Stöhr, E; Hamm, C; Walther, T; Brandt, R; Frühauf, A-C; Hartung, C; Hellner, C; Wild, C; Becker, M; Hamada, S; Kaestner, W; Stangl, K; Knebel, F; Baldenhofer, G; Brecht, A; Dreger, H; Isner, C; Pfafflin, F; Stegemann, M; Zahn, R; Fraiture, B; Kilkowski, C; Karcher, A-K; Klinger, S; Tolksdorf, H; Tousoulis, D; Aggeli, C; Sarri, G; Sideris, S; Venieri, E; Athanassopoulos, G; Tsiapras, D; Armenis, I; Koutsiari, A; Floros, G; Grassos, C; Dragasis, S; Rallidis, L; Varlamos, C; Michalis, L; Naka, K; Bechlioulis, A; Kotsia, A; Lakkas, L; Pappas, K; Papadopoulos, C; Kiokas, S; Lioni, A; Misailidou, S; Barbetseas, J; Bonou, M; Kapelios, C; Tomprou, I; Zerva, K; Manolis, A; Hamodraka, E; Athanasiou, D; Haralambidis, G; Poulimenos, L; Samaras, H; Nagy, A; Bartykowszki, A; Gara, E; Sengupta, S; Mungulmare, K; Kasliwal, R; Bansal, M; Bhan, A; Ranjan, S; Kyavar, M; Maleki, M; Noohi Bezanjani, F; Sadeghpour, A; Alizadehasl, A; Boudagh, S; Ghavidel, A; Moradnejad, P; Pasha, H; Ghadrdoost, B; Gilon, D; Strahilevitz, J; Israel, S; Wanounou, M; d'Agostino, C; Colonna, P; de Michele, L; Fumarola, F; Stante, M; Marchionni, N; Scheggi, V; Alterini, B; del Pace, S; Stefano, P; Sparano, C; Badano, L; Muraru, D; Ruozi, N; Tenaglia, R; Limbruno, U; Cresti, A; Baratta, P; Solari, M; Giannattasio, C; Moreo, A; de Chiara, B; Lopez Montero, B; Musca, F; Orcese, C; Panzeri, F; Russo, C; Spano, F; Alfieri, O; de Bonis, M; Agricola, E; Busnardo, E; Carletti, S; Castiglioni, B; Chiappetta, S; del Forno, B; Ferrara, D; Guffanti, M; Iaci, G; Lapenna, E; Nisi, T; Oltolini, C; Pajoro, U; Pasciuta, R; Ripa, M; Scarpellini, P; Tassan Din, C; Meneghin, R; Schiavi, D; Piscione, F; Citro, R; Benvenga, R; Greco, L; Prota, C; Radano, I; Soriente, L; Bellino, M; Di Vece, D; Santini, F; Salsano, A; Olivieri, G; Turrini, F; Messora, R; Tondi, S; Olaru, A; Agnoletto, V; Grassi, L; Leonardi, C; Sansoni, S; del Ponte, S; Actis Dato, G; de Martino, A; Ohte, N; Kikuchi, S; Wakami, K; Aonuma, K; Seo, Y; Ishizu, T; Machino-Ohtsuka, T; Yamamoto, M; Iida, N; Nakajima, H; Nakagawa, Y; Izumi, C; Amano, M; Miyake, M; Takahashi, K; Shiojima, I; Miyasaka, Y; Maeba, H; Suwa, Y; Taniguchi, N; Tsujimoto, S; Kitai, T; Ota, M; Yuda, S; Sasaki, S; Hagiwara, N; Yamazaki, K; Ashihara, K; Arai, K; Saitou, C; Saitou, S; Suzuki, G; Shibata, Y; Watanabe, N; Nishino, S; Ashikaga, K; Kuriyama, N; Mahara, K; Abe, K; Fujimaki, H; Okubo, T; Shitan, H; Takanashi, S; Terada, M; Yamamoto, H; Sata, M; Yamada, H; Kusunose, K; Saijo, Y; Seno, H; Yuichiro, O; Sakata, Y; Mizuno, H; Nakatani, S; Onishi, T; Sengoku, K; Sera, F; Park, S; Eun Kyoung, K; Ga Yeon, L; Hwang, J-W; Jin-Oh, C; Park, S-J; Sang-Chol, L; Sung-A, C; Jang, S; Kang, D-H; Heo, R; Lee, S; Song, J-M; Jung, E; Plisiene, J; Dambrauskaite, A; Gruodyte, G; Jonkaitiene, R; Vaskelyte, J; Mizariene, V; Atkocaityte, J; Zvirblyte, R; Sow, R; Codreanu, A; de la Vega, E; Michaux, C; Staub, T; Jacobs-Orazi, L; Mallia Azzopardi, C; Xuereb, R; Piscopo, T; Borg, D; Casha, R; Farrugia, J; Fenech, M; Pllaha, E; Vella, C; Yamagata, K; Grib, L; Raevschi, E; Grejdieru, A; Balan, G; Cardaniuc, I; Cardaniuc, L; Corcea, V; Feodorovici, A; Gaina, V; Girbu, L; Jimbei, P; Kravcenco, D; Panfile, E; Prisacari, E; Samohvalov, E; Samohvalov, S; Sceglova, N; Benesco, I; Marian, V; Sumarga, N; Mirocevic, M; Bozovic, B; Bulatovic, N; Lakovic, P; Music, L; Roos-Hesselink, J; Budde, R; Gamela, T; Wahadat, A; Kamp, O; Meijers, T; van Melle, J; Deursen, V; Crijns, H; Bekkers, S; Cheriex, E; Gilbers, M; Kietselaer, B; Knackstedt, C; Lorusso, R; Schalla, S; Streukens, S; Chamuleau, S; Cramer, M-J; Teske, A; van der Spoel, T; Wind, A; Liesbek, O; Lokhorst, J; van Heusden, H; Tanis, W; van der Bilt, I; Vriend, J; de Lange-van Bruggen, H; Karijodikoro, E; Riezebos, R; van Dongen, E; Schoep, J; Stolk, V; Axler, O; Baumann, F; Lebras, S; Edvardsen, T; Offstad, J; Beitnes, J; Helle-Valle, T; Skulstad, H; Skardal, R; Qamar, N; Furnaz, S; Ahmed, B; Butt, M; Khanzada, M; Saghir, T; Wahid, A; Hryniewiecki, T; Szymanski, P; Marzec, K; Misztal-Ogonowska, M; Kosmala, W; Przewlocka-Kosmala, M; Rojek, A; Woznicka, K; Zachwyc, J; Lisowska, A; Kaminska, M; Kasprzak, J; Kowalczyk, E; Strzecka, D; Wejner-Mik, P; Trabulo, M; Freitas, P; Ranchordas, S; Rodrigues, G; Pinto, P; Queiros, C; Azevedo, J; Marques, L; Seabra, D; Branco, L; Cruz, M; Galrinho, A; Moreira, R; Rio, P; Timoteo, A; Selas, M; Cardim, N; Carmelo, V; Duque Neves, B; Pereira, H; Cruz, I; Guerra, A; Marques, A; Pintassilgo, I; Tomescu, M; Trofenciuc, N-M; Andor, M; Bordejevic, A; Branea, H; Caruntu, F; Cirin, L; Citu, I; Cotoraci, C; Darabantiu, D; Farcas, R; Marincu, I; Mavrea, A; Onel, M; Parvanescu, T; Pop, D; Pop-Moldovan, A; Puticiu, M; Velcean, L; Ionac, A; Cozma, D; Mornos, C; Goanta, F; Popescu, I; Beyer, R; Mada, R; Rancea, R; Rosianu, H; Tomoaia, R; Stanescu, C; Kobalava, Z; Karaulova, J; Kotova, E; Milto, A; Pisaryuk, A; Povalyaev, N; Sorokina, M; Alrahimi, J; Elshiekh, A; Jamiel, A; Ahmed, A; Al-Mallah, M; Attia, N; Putnikovic, B; Neskovic, A; Dimic, A; Ivanovic, B; Matic, S; Trifunovic, D; Petrovic, J; Kosevic, D; Dabic, P; Milojevic, P; Petrovic, I; Stojanovic, I; Srdanovic, I; Kovacevic, M; Redzek, A; Stefanovic, M; Susak, S; Velicki, L; Vulin, A; Yeo, T; Kong, W; Poh, K; Vilacosta, I; Abd El-Nasser, M; Ferrera, C; Olmos, C; Calvo Iglesias, F; Blanco-Gonzalez, E; Bravo Amaro, M; Germinas, A; Lopez-Rodriguez, E; Lugo Adan, J; Pazos-Lopez, P; Pereira Loureiro, M; Perez, M; Raposeiras-Roubin, S; Rasheed Yas, S; Suarez-Varela, M-M; Vasallo Vidal, F; Garcia-Dorado, D; Sambola, A; Fernandez-Hidalgo, N; Gonzalez-Alujas, T; Lozano, J; Maisterra, O; Pizzi, N; Rios, R; Tornos, P; Bayes-Genis, A; Pedro Botet, L; Vallejo, N; Berastegui, E; Llibre, C; Mateu, L; Nunez, R; Quesada, D; Bosch Portell, D; Aboal Vinas, J; Albert Bertran, X; Brugada Tarradellas, R; Loma-Osorio Ricon, P; Tiron de Llano, C; Arnau, M; Bel, A; Blanes, M; Osa, A; Anguita, M; Carrasco, F; Castillo, J; Zamorano, J; Moya Mur, J; Alvaro, M; Fernandez-Golfin, C; Monteagudo, J; Navas Elorza, E; Farinas Alvarez, M; Aguero Balbin, J; Arminanzas, C; Arnaiz de las Revillas, F; Arnaiz Garcia, A; Cobo Belaustegui, M; Fernandez Sampedro, M; Gutierrez Cuadra, M; Gutierrez-Diez, J; Zarauza, J; Garcia Cuello, L; Gonzalez Rico, C; Rodriguez-Alvarez, R; Goikoetxea, J; Montejo, M; Miro, J; Almela, M; Ambrosioni, J; Falces, C; Fuster, D; Garcia-De-La-Maria, C; Hernandez-Meneses, M; Llopis, J; Marco, F; Moreno, A; Quintana, E; Sandoval, E; Tellez, A; Tolosana, J; Vidal, B; Ruiz-Zamora, I; Bardaji Ruiz, A; Sanz Girgas, E; Garcia-Pardo, G; Guillen Marzo, M; Rodriguez Oviedo, A; Villares Jimenez, A; Abid, L; Hammami, R; Kammoun, S; Mourali, M; Mghaieth Zghal, F; Ben Hlima, M; Boudiche, S; Ouali, S; Zakhama, L; Antit, S; Slama, I; Gulel, O; Sahin, M; Sade, L; Karacaglar, E; Kucukoglu, S; Cetinarslan, O; Yasar, U; Canpolat, U; Mutlu, B; Atas, H; Dervishova, R; Ileri, C; Zaky, H; Alhashmi, J; Baslib, F; Tahir, J; Zarger, P; Woldman, S; Menezes, L; Primus, C; Uppal, R; Bvekerwa, I; Chandrasekaran, B; Kopanska, A; Prendergast, B; Cannata, S; Chambers, J; Hancock, J; Klein, J; Rajani, R; Ursi, M; Dworakowski, R; Fife, A; Breeze, J; Browne-Morgan, M; Gunning, M; Streather, S; Asch, F; Zemedkun, M; Alyavi, B; Uzokov, J |
| Contributors: |
Département de Cardiologie Hôpital de la Timone - APHM; Assistance Publique - Hôpitaux de Marseille (APHM)-Hôpital de la Timone CHU - APHM (TIMONE); Sciences Economiques et Sociales de la Santé & Traitement de l'Information Médicale (SESSTIM - U1252 INSERM - Aix Marseille Univ - UMR 259 IRD); Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM); Institut des sciences de la santé publique Marseille (ISSPAM); Hôpital de la Timone CHU - APHM (TIMONE); Università degli Studi del Molise = University of Molise (UNIMOL); Universitair Ziekenhuis Brussel = University Hospital of Brussels (UZ Brussel); Centre Hospitalier Universitaire de Rennes CHU Rennes = Rennes University Hospital Pontchaillou; CIC-IT Rennes; Centre Hospitalier Universitaire de Rennes CHU Rennes = Rennes University Hospital Pontchaillou -Institut National de la Santé et de la Recherche Médicale (INSERM); Laboratoire Traitement du Signal et de l'Image (LTSI); Université de Rennes (UR)-Institut National de la Santé et de la Recherche Médicale (INSERM); University of Pisa Italy = Università di Pisa Italia = Université de Pise Italie (UniPi); Institut Hospitalier Universitaire Méditerranée Infection (IHU Marseille); Microbes Evolution Phylogénie et Infections (MEPHI); Aix Marseille Université (AMU); AP-HP - Hôpital Bichat - Claude Bernard Paris; Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP); Laboratoire de Recherche Vasculaire Translationnelle (LVTS (UMR_S_1148 / U1148)); Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité)-Université Sorbonne Paris Nord; National University Hospital Singapore (NUH); GIGA Institute Université de Liège (GIGA Liège ); Université de Liège = University of Liège = Universiteit van Luik = Universität Lüttich (ULiège); Centre Hospitalier Universitaire Sart Tilman (CHU Sart Tilman); Université de Liège = University of Liège = Universiteit van Luik = Universität Lüttich (ULiège)-Centre Hospitalier Universitaire de Liège (CHU-Liège); Associazione Nazionale Medici Cardiologi Ospedalieri Firenze (ANMCO); University of Medicine and Pharmacy “Carol Davila” (UMPCD); Cleveland Clinic London Hospital London; Department of cardiology Guy's and St. Thomas ' hospitals London; Guy's and St Thomas' Hospital London -Guy's Hospital London; Vall d'Hebron University Hospital Barcelona; Sengupta Hospital and Research Institute Nagpur; Service de Cardiologie Amiens; CHU Amiens-Picardie; Mécanismes physiopathologiques et conséquences des calcifications cardiovasculaires - UR UPJV 7517 (MP3CV); Université de Picardie Jules Verne (UPJV)-CHU Amiens-Picardie; University of Groningen Groningen; Biostatistique et technologies de l'information et de la communication (BioSTIC) - Hôpital de la Timone - APHM (BiosTIC); Abbott Cardiovascular. (2011–21), Amgen Cardiovascular (2009–18), AstraZeneca (2014–21), Bayer AG (2009–18), Boehringer Ingelheim (2009–19), Boston Scientific Corporation (2009–12), The Bristol Myers Squibb and Pfizer Alliance (2011–19), Daiichi Sankyo Europe GmbH (2011–20), The Alliance Daiichi Sankyo Europe GmbH and Eli Lilly and Company (2014–17), Edwards (2016–19), Gedeon Richter Plc. (2014–16), Menarini Int. Op. (2009–12), MSD Sharp and Dohme-Merck & Co. (2011–14), Novartis Pharma AG (2014–20), ResMed (2014–16), Sanofi (2009–11), SERVIER (2009–21), and Vifor (2019–22). |
| Source: |
ISSN: 2058-5225. |
| Publisher Information: |
CCSD; Oxford University Press |
| Publication Year: |
2026 |
| Subject Terms: |
Dual beta-lactam therapy; Enterococcal endocarditis; Healthcare-associated infection; Surgical management; Recurrence; Prosthetic valve infection; [SDV.MHEP.CSC]Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system |
| Description: |
International audience ; Background Enterococcal infective endocarditis (EIE) represents a growing proportion of infective endocarditis (IE) cases, particularly among elderly and comorbid patients. EIE poses diagnostic and therapeutic challenges, notably regarding optimal antimicrobial therapy and surgical decision-making. We aimed to compare the clinical characteristics, management, and outcomes of EIE versus non-enterococcal IE (NEIE) in the ESC-EORP EURO-ENDO registry. Methods This ancillary analysis of the prospective EURO-ENDO registry included adult patients with definite or possible IE enrolled between January 2016 and March 2018. Patients with monomicrobial EIE were compared with those with NEIE. Clinical, microbiological, imaging, and therapeutic data were analyzed. Multivariable logistic regression including EuroSCORE II and valve status identified independent predictors of in-hospital mortality. Results Among 3 083 patients, 365 (12 %) had monomicrobial EIE. Compared with NEIE, EIE patients were older (mean 68 vs 58 years), had more comorbidities, and more frequent prosthetic valve involvement (41 % vs 26 %). Aortic valve localization and colonic uptake on PET/CT were also more common. In-hospital mortality was similar (16 % vs 17 %). After adjustment for EuroSCORE II and valve status, EIE was not independently associated with higher in-hospital mortality (adjusted OR 0.67 [95 % CI 0.42–1.04]; p = 0.083). Among 195 EIE patients with one-year follow-up, recurrence occurred in 6 %. Healthcare-associated acquisition, prosthetic valve infection, and recurrence were associated with worse outcomes and lower surgical rates. Conclusions EIE affects older, high-risk patients. After adjustment for operative risk, mortality was comparable to other etiologies, highlighting the need for tailored diagnostic and therapeutic strategies. |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| Relation: |
info:eu-repo/semantics/altIdentifier/pmid/41299837; PUBMED: 41299837 |
| DOI: |
10.1093/ehjqcco/qcaf145 |
| Availability: |
https://u-picardie.hal.science/hal-05391236; https://u-picardie.hal.science/hal-05391236v1/document; https://u-picardie.hal.science/hal-05391236v1/file/Philip%20-%202025%20-%20Clinical%20Characteristics,%20Management%20and%20Outcomes%20of%20Enterococcal%20Infective%20Endocarditis%20_ARTICLE%20FINAL%20REVIEW%20marked%20up%20changes%20accepted.docx.pdf; https://doi.org/10.1093/ehjqcco/qcaf145 |
| Rights: |
https://creativecommons.org/licenses/by-nc/4.0/ |
| Accession Number: |
edsbas.A7AF075 |
| Database: |
BASE |