| Title: |
The Helicobacter pylori Genome Project : insights into H. pylori population structure from analysis of a worldwide collection of complete genomes |
| Authors: |
Thorell, Kaisa; Muñoz-Ramírez, Zilia Y.; Wang, Difei; Sandoval-Motta, Santiago; Boscolo Agostini, Rajiv; Ghirotto, Silvia; Torres, Roberto C.; Romero-Gallo, Judith; Krishna, Uma; Peek, Richard M.; Piazuelo, M. Blanca; Raaf, Naïma; Bentolila, Federico; Aftab, Hafeza; Akada, Junko; Matsumoto, Takashi; Haesebrouck, Freddy; Colanzi, Rony P.; Bartelli, Thais F.; Nunes, Diana Noronha; Pelosof, Adriane; Sztokfisz, Claudia Zitron; Dias-Neto, Emmanuel; Assumpção, Paulo Pimentel; Tishkov, Ivan; Mabeku, Laure Brigitte Kouitcheu; Goodman, Karen J.; Geary, Janis; Cromarty, Taylor J.; Price, Nancy L.; Quilty, Douglas; Corvalan, Alejandro H.; Serrano, Carolina A.; Gonzalez, Robinson; Riquelme, Arnoldo; García-Cancino, Apolinaria; Parra-Sepúlveda, Cristian; Bernal, Giuliano; Castillo, Francisco; Goldstein, Alisa M.; Hu, Nan; Taylor, Philip R.; Bravo, Maria Mercedes; Pazos, Alvaro; Bravo, Luis E.; Wilson, Keith T.; Fox, James G.; Ramírez-Mayorga, Vanessa; Molina-Castro, Silvia; Durán-Bermúdez, Sundry; Campos-Núñez, Christian; Chaves-Cervantes, Manuel; Tshibangu-Kabamba, Evariste; Tumba, Ghislain Disashi; Tshimpi-Wola, Antoine; de Jesus Ngoma-Kisoko, Patrick; Ngoyi, Dieudonné Mumba; Cruz, Modesto; Hosking, Celso; Abreu, José Jiménez; Varon, Christine; Benejat, Lucie; Secka, Ousman; Link, Alexander; Malfertheiner, Peter; Adinortey, Michael Buenor; Bockarie, Ansumana Sandy; Adinortey, Cynthia Ayefoumi; Ofori, Eric Gyamerah; Sgouras, Dionyssios N.; Martinez-Gonzalez, Beatriz; Michopoulos, Spyridon; Georgopoulos, Sotirios; Hernandez, Elisa; Tacatic, Braulio Volga; Aguilar, Mynor; Dominguez, Ricardo L.; Morgan, Douglas R.; Harðardóttir, Hjördís; Gunnarsdóttir, Anna Ingibjörg; Guðjónsson, Hallgrímur; Jónasson, Jón Gunnlaugur; Björnsson, Einar S.; Ballal, Mamatha; Shetty, Vignesh; Miftahussurur, Muhammad; Sugihartono, Titong; Alfaray, Ricky Indra; Waskito, Langgeng Agung; Fauzia, Kartika Afrida; Syam, Ari Fahrial; Maulahela, Hasan; Malekzadeh, Reza; Sotoudeh, Masoud; Peretz, Avi; Azrad, Maya; On, Avi; De Re, Valli; Zanussi, Stefania; Cannizzaro, Renato; Canzonieri, Vincenzo; Shimura, Takaya; Tokunaga, Kengo; Osaki, Takako; Kamiya, Shigeru; Jadallah, Khaled; Matalka, Ismail; Igissinov, Nurbek; Moldobaeva, Mariia Satarovna; Rakhat, Attokurova; Choi, Il Ju; Kim, Jae Gyu; Kim, Nayoung; Song, Minkyo; Leja, Mārcis; Vangravs, Reinis; Šķenders, Ģirts; Rudzīte, Dace; Rūdule, Aiga; Vanags, Aigars; Kikuste, Ilze; Kupcinskas, Juozas; Skieceviciene, Jurgita; Jonaitis, Laimas; Kiudelis, Gediminas; Jonaitis, Paulius; Kiudelis, Vytautas; Varkalaite, Greta; Vadivelu, Jamuna; Loke, Mun Fai; Vellasamy, Kumutha Malar; Herrera-Goepfert, Roberto; Alonso-Larraga, Juan Octavio; Yee, Than Than; Htet, Kyaw; Matsuhisa, Takeshi; Shrestha, Pradeep Krishna; Ansari, Shamshul; Abiodun, Olumide; Jemilohun, Christopher; Akande, Kolawole Oluseyi; Olu-Abiodun, Oluwatosin; Magaji, Francis Ajang; Omotoso, Ayodele; Osuagwu, Chukwuemeka Chukwunwendu; Okonkwo, Uchenna; Owoseni, Opeyemi O.; Castaneda, Carlos; Castillo, Miluska; Velapatino, Billie; Gilman, Robert H.; Krzyżek, Paweł; Gościniak, Grażyna; Pawełka, Dorota; Korona-Glowniak, Izabela; Cichoz-Lach, Halina; Oleastro, Monica; Figueiredo, Ceu; Machado, Jose C.; Ferreira, Rui M.; Bordin, Dmitry S.; Livzan, Maria A.; Tsukanov, Vladislav V.; Tan, Patrick; Yeoh, Khay Guan; Zhu, Feng; Ally, Reid; Haas, Rainer; Montes, Milagrosa; Fernández-Reyes, María; Tamayo, Esther; Lizasoain, Jacobo; Bujanda, Luis; Lario, Sergio; Ramírez-Lázaro, María José; Calvet, Xavier; Brunet-Mas, Eduard; Domper-Arnal, María José; García-Mateo, Sandra; Abad-Baroja, Daniel; Delgado-Guillena, Pedro; Moreira, Leticia; Botargues, Josep; Pérez-Martínez, Isabel; Barreiro-Alonso, Eva; Flores, Virginia; Gisbert, Javier P.; Muro, Edurne Amorena; Linares, Pedro; Martin, Vicente; Alcoba, Laura; Fleitas-Kanonnikoff, Tania; Altayeb, Hisham N.; Engstrand, Lars; Enroth, Helena; Keller, Peter M.; Wagner, Karoline; Pohl, Daniel; Lee, Yi-Chia; Liou, Jyh-Ming; Wu, Ming-Shiang; Kocazeybek, Bekir; Sarıbas, Suat; Tasçı, İhsan; Demiryas, Süleyman; Kepil, Nuray; Quiel, Luis; Villagra, Miguel; Norton, Morgan; Johnson, Deborah; Huang, Robert J.; Hwang, Joo Ha; Szymczak, Wendy; Rajagopalan, Saranathan; Asare, Emmanuel; Jacobs, William R.; In, Haejin; Bollag, Roni; Lopez, Aileen; Kruse, Edward J.; White, Joseph; Graham, David Y.; Lane, Charlotte; Gao, Yang; Fields, Patricia I.; Gold, Benjamin D.; Cruz-Correa, Marcia; González-Pons, María; Rodriguez, Luz M.; Tuan, Vo Phuoc; Dung, Ho Dang Quy; Binh, Tran Thanh; Trang, Tran Thi Huyen; Van Khien, Vu; Chen, Xiongfong; Raley, Castle; Kessing, Bailey; Zhao, Yongmei; Tran, Bao; Gutiérrez-Escobar, Andrés J.; Wan, Yunhu; Hicks, Belynda; Zhu, Bin; Yu, Kai; Yeager, Meredith; Hutchinson, Amy; Teshome, Kedest; Jones, Kristie; Luo, Wen; Jehanne, Quentin; Katsura, Yukako; Gonzalez-Hormazabal, Patricio; Didelot, Xavier; Sheppard, Sam; Tarazona-Santos, Eduardo; Mariño-Ramírez, Leonardo; Loh, John T.; Backert, Steffen; Naumann, Michael; Abnet, Christian C.; Smet, Annemieke; Berg, Douglas E.; Chiner-Oms, Álvaro; Comas, Iñaki; Martínez-Martínez, Francisco José; Zamudio, Roxana; Lehours, Philippe; Megraud, Francis; Yahara, Koji; Blaser, Martin J.; Vincze, Tamas; Morgan, Richard D.; Roberts, Richard J.; Chanock, Stephen J.; Dekker, John P.; Torres, Javier; Cover, Timothy L.; Noureen, Mehwish; Fischer, Wolfgang; Vale, Filipa F.; Cherry, Joshua L.; Osada, Naoki; Fukuyo, Masaki; Arita, Masanori; Yamaoka, Yoshio; Kobayashi, Ichizo; Uchiyama, Ikuo; Falush, Daniel; Camargo, M. Constanza; Rabkin, Charles S. |
| Publisher Information: |
Nature Publishing Group |
| Publication Year: |
2023 |
| Collection: |
The University of Warwick: WRAP - Warwick Research Archive Portal |
| Subject Terms: |
QR Microbiology |
| Description: |
Helicobacter pylori, a dominant member of the gastric microbiota, shares co-evolutionary history with humans. This has led to the development of genetically distinct H. pylori subpopulations associated with the geographic origin of the host and with differential gastric disease risk. Here, we provide insights into H. pylori population structure as a part of the Helicobacter pylori Genome Project (HpGP), a multi-disciplinary initiative aimed at elucidating H. pylori pathogenesis and identifying new therapeutic targets. We collected 1011 well-characterized clinical strains from 50 countries and generated high-quality genome sequences. We analysed core genome diversity and population structure of the HpGP dataset and 255 worldwide reference genomes to outline the ancestral contribution to Eurasian, African, and American populations. We found evidence of substantial contribution of population hpNorthAsia and subpopulation hspUral in Northern European H. pylori. The genomes of H. pylori isolated from northern and southern Indigenous Americans differed in that bacteria isolated in northern Indigenous communities were more similar to North Asian H. pylori while the southern had higher relatedness to hpEastAsia. Notably, we also found a highly clonal yet geographically dispersed North American subpopulation, which is negative for the cag pathogenicity island, and present in 7% of sequenced US genomes. We expect the HpGP dataset and the corresponding strains to become a major asset for H. pylori genomics. |
| Document Type: |
article in journal/newspaper |
| File Description: |
application/pdf |
| Language: |
English |
| ISSN: |
2041-1723 |
| Relation: |
https://wrap.warwick.ac.uk/id/eprint/182340/1/s41467-023-43562-y.pdf; Thorell, Kaisa, Muñoz-Ramírez, Zilia Y., Wang, Difei, Sandoval-Motta, Santiago, Boscolo Agostini, Rajiv, Ghirotto, Silvia, Torres, Roberto C., Romero-Gallo, Judith, Krishna, Uma, Peek, Richard M. et al. (2023) The Helicobacter pylori Genome Project : insights into H. pylori population structure from analysis of a worldwide collection of complete genomes. Nature Communications, 14 (1). 8184. doi:10.1038/s41467-023-43562-y ISSN 2041-1723. |
| DOI: |
10.1038/s41467-023-43562-y |
| Availability: |
https://wrap.warwick.ac.uk/id/eprint/182340/; https://doi.org/10.1038/s41467-023-43562-y |
| Rights: |
cc_by_4 |
| Accession Number: |
edsbas.A7B133 |
| Database: |
BASE |