| Title: |
The prognostic value of Ki67 in systemically untreated patients with node-negative breast cancer |
| Authors: |
Pathmanathan, Nirmala; Balleine, Rosemary; Jayasinghe, Upali W.; Bilinski, Kellie (R18510); Provan, Pamela; Byth, Karen; Bilous, Michael; Salisbury, Elizabeth (R14533); Boyages, John |
| Contributors: |
National Institute of Complementary Medicine (Host institution) |
| Publisher Information: |
U.K., BMJ Group |
| Publication Year: |
2014 |
| Collection: |
University of Western Sydney (UWS): Research Direct |
| Subject Terms: |
111201 - Cancer Cell Biology; 920102 - Cancer and Related Disorders; cancer; breast; patients; tumors |
| Description: |
Aim To evaluate the utility of Ki67 as a prognostic marker in a series of patients with node-negative breast cancer untreated with adjuvant systemic therapy. Methods The cohort consisted of 203 cases treated with breast conserving surgery and radiation only; median follow-up was 183 months (range 156-277 months). An immunohistochemical panel of oestrogen receptor (ER), progesterone receptor (PR), cytokeratin (CK)5/6 and Ki67 and human epidermal growth factor 2 in situ hybridization (HER2-ISH) was performed on the tumour samples. Ki67 scores were evaluable in 193/203 patients (95.1%). The primary outcome was breast cancer specific survival (BCSS). Results Of the cohort, 29 (14.2%) died of breast cancer. A cut off of 10% separated tumours into a 'Ki67-low' (n=70) or 'Ki67-high' group (n=123). The breast cancer specific survival was 97.1% and 77.6% for Ki67-low and Ki67-high groups, respectively. Univariate analysis showed that in this lymph node-negative cohort, the predictors for BCSS were tumour size, Ki67, LVI, age and histological grade 3. Multivariable analysis showed that Ki67 index and lymphovascular space invasion were independent predictors of breast cancer death. To examine the utility of Ki67 in assignment of immunohistochemically molecular subtypes, cases were assigned into Luminal A (ER-positive, HER2-negative, Ki67 ≤14%), Luminal B (ER-positive, HER2-negative, Ki67 |
| Document Type: |
article in journal/newspaper |
| File Description: |
print |
| Language: |
English |
| Relation: |
Journal of Clinical Pathology--0021-9746 Vol. 67 Issue. 3 pp: 222-228 |
| DOI: |
10.1136/jclinpath-2013-201793 |
| Availability: |
https://doi.org/10.1136/jclinpath-2013-201793; http://handle.westernsydney.edu.au:8081/1959.7/uws:40475 |
| Rights: |
This is an Open Access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. |
| Accession Number: |
edsbas.A7DA363F |
| Database: |
BASE |