| Title: |
Polylactide/Hydroxyapatite Nonwovens Incorporated into Chitosan/Graphene Materials Hydrogels to Form Novel Hierarchical Scaffolds |
| Authors: |
Karolina Kosowska; Patrycja Domalik-Pyzik; Małgorzata Krok-Borkowicz; Jan Chłopek |
| Source: |
International Journal of Molecular Sciences, Vol 21, Iss 7, p 2330 (2020) |
| Publisher Information: |
MDPI AG |
| Publication Year: |
2020 |
| Collection: |
Directory of Open Access Journals: DOAJ Articles |
| Subject Terms: |
polylactide; chitosan; polymer composite; electrospinning; hydrogel; Biology (General); QH301-705.5; Chemistry; QD1-999 |
| Description: |
In this study, hierarchical, cylindrical scaffolds based on polylactide (PLA) microfibers incorporated into chitosan (CS) hydrogel were prepared for potential use in bone tissue engineering. PLA nonwovens modified with hydroxyapatite particles (HAp) were obtained using the electrospinning method. Then, three-dimensional scaffolds were created by rolling up the nonwovens and immersing them in CS-based solutions with graphene oxide (GO) or reduced graphene oxide (rGO) dispersed in the polymer matrix. Hydrogels were cross-linked using a novel freezing-thawing-gelling method. A broad spectrum of research methods was applied in order to thoroughly characterize both the nanofillers and the composite systems: scanning electron microscopy, X-ray photoelectron spectroscopy, X-ray diffractometry, attenuated total reflection Fourier transform infrared spectroscopy, rheological and mechanical testing, as well as the assessment of chemical stability, bioactivity and cytocompatibility. |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| Relation: |
https://www.mdpi.com/1422-0067/21/7/2330; https://doaj.org/toc/1661-6596; https://doaj.org/toc/1422-0067; https://doaj.org/article/361eee75161247f0b45145a96843c405 |
| DOI: |
10.3390/ijms21072330 |
| Availability: |
https://doi.org/10.3390/ijms21072330; https://doaj.org/article/361eee75161247f0b45145a96843c405 |
| Accession Number: |
edsbas.A7DF9FCC |
| Database: |
BASE |