| Title: |
Impact of Sex on Residual Angina After Percutaneous Coronary Interventions. |
| Authors: |
Hada, M.; Mizukami, T.; Ikeda, K.; Munhoz, D.; Brouwers, S.; Sonck, J.; Matsuo, H.; Shinke, T.; Ando, H.; Ko, B.; Biscaglia, S.; Rivero, F.; Engstrøm, T.; Arslani, K.; Leone, A.M.; Galante, D.; Nunen, L.X. van; Fearon, W.F.; Christiansen, E.H.; Fournier, S.; Desta, L.; Yong, A.; Adjedj, J.; Escaned, J.; Nakayama, M.; Eftekhari, A.; Zimmermann, F.M.; Sakai, K.; Storozhenko, T.; Costa, B.R. da; Campo, G.; Berry, C.; Collison, D.; Johnson, T.; Amano, T.; Perera, D.; Jeremias, A.; Ali, Z.; Bruyne, B. de; Barbato, P.; Corradetti, S.; Stalikas, N.; Kechichian, A.; Bouisset, F.; Kakuta, T.; Johnson, N.P.; Collet, C. |
| Source: |
Catheterization and Cardiovascular Interventions, 107, 4, pp. 987-996 |
| Publication Year: |
2026 |
| Collection: |
Radboud University: DSpace |
| Subject Terms: |
Cardiology - Radboud University Medical Center |
| Description: |
Contains fulltext : 329819.pdf (Publisher’s version ) (Closed access) ; BACKGROUND: Sex-related differences in the clinical presentation of coronary artery disease (CAD) are well recognized. The pullback pressure gradient (PPG) characterizes pathophysiological CAD patterns as focal or diffuse. OBJECTIVES: To evaluate the influence of sex on residual angina at one year after percutaneous coronary intervention (PCI), stratified by PPG. METHODS: We performed a sub-analysis of PPG Global, a multicenter, prospective, single-arm study. All patients had hemodynamically significant CAD (fractional flow reserve [FFR] ≤ 0.80) and underwent a manual FFR pullbacks to calculate PPG before PCI. Patient-reported outcomes were collected using the 7-item Seattle Angina Questionnaire (SAQ-7) at baseline and 1-year follow-up. RESULTS: We included 814 patients (205 [25.2%] women and 609 [74.8%] men). Women were significantly older than men (70 ± 10 years vs. 67 ± 10 years p < 0.001). Baseline FFR were comparable between sexes (0.68 ± 0.13 vs. 0.66 ± 0.12, p = 0.098), but women had a more focal CAD compared to men (PPG 0.66 ± 0.15 vs. 0.63 ± 0.15, p = 0.047). Post PCI-FFR was higher in women than men (0.88 ± 0.07 vs. 0.87 ± 0.07, p = 0.041); however, angina at 1 year was more frequent in women (SAQ angina frequency score 94 ± 12 vs. 96 ± 10, p = 0.041). CONCLUSION: Despite having a more focal CAD pattern and achieving higher post-PCI FFR, women report more residual angina than men at 1-year follow-up. TRIAL REGISTRATION: ClinicalTrials.gov NCT04789317. |
| Document Type: |
article in journal/newspaper |
| Language: |
unknown |
| Relation: |
https://hdl.handle.net/2066/329819 |
| DOI: |
10.1002/ccd.70419 |
| Availability: |
https://hdl.handle.net/2066/329819; https://doi.org/10.1002/ccd.70419 |
| Accession Number: |
edsbas.A8314D0 |
| Database: |
BASE |