| Title: |
A strategic model of a host-microbe-microbe system reveals the importance of a joint host-microbe immune response to combat stress-induced gut dysbiosis. |
| Authors: |
Scheuring, I.; Rasmussen, J.A.; Bozzi, D.; Limborg, M.T. |
| Publication Year: |
2022 |
| Collection: |
Université de Lausanne (UNIL): Serval - Serveur académique lausannois |
| Subject Terms: |
Aliivibrio sp; Mycoplasma sp; bistability; microbiome; mutualism; pathogens; salmonids; stress |
| Description: |
Microbiomes provide key ecological functions to their host; however, most host-associated microbiomes are too complicated to allow a model of essential host-microbe-microbe interactions. The intestinal microbiota of salmonids may offer a solution since few dominating species often characterize it. Healthy fish coexist with a mutualistic Mycoplasma sp. species, while stress allows the spread of pathogenic strains, such as Aliivibrio sp. Even after a skin infection, the Mycoplasma does not recover; Aliivibrio sp. often remains the dominant species, or Mycoplasma-Aliivibrio coexistence was occasionally observed. We devised a model involving interactions among the host immune system, Mycoplasma sp. plus a toxin-producing pathogen. Our model embraces a complete microbiota community and is in harmony with experimental results that host-Mycoplasma mutualism prevents the spread of pathogens. Contrary, stress suppresses the host immune system allowing dominance of pathogens, and Mycoplasma does not recover after stress disappears. |
| Document Type: |
article in journal/newspaper |
| File Description: |
application/pdf |
| Language: |
English |
| ISSN: |
1664-302X |
| Relation: |
Frontiers in Microbiology; https://iris.unil.ch/handle/iris/125757; serval:BIB_1083624C0363; 000843077500001 |
| DOI: |
10.3389/fmicb.2022.912806 |
| Availability: |
https://iris.unil.ch/handle/iris/125757; https://doi.org/10.3389/fmicb.2022.912806 |
| Accession Number: |
edsbas.A8643261 |
| Database: |
BASE |