P-109 ALKALINE PHOSPHATASE AND CIRRHOSIS AT DIAGNOSIS ARE ASSOCIATED WITH DEEP RESPONSE TO URSODEOXYCHOLIC ACID IN PRIMARY BILIARY CHOLANGITIS
| Title: | P-109 ALKALINE PHOSPHATASE AND CIRRHOSIS AT DIAGNOSIS ARE ASSOCIATED WITH DEEP RESPONSE TO URSODEOXYCHOLIC ACID IN PRIMARY BILIARY CHOLANGITIS |
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| Authors: | Guilherme Grossi Lopes Cançado; Patricia Fucuta; Nathalia Mota de Faria Gomes; Claudia Alves Couto; Eduardo Luiz Rachid Cançado; Debora Raquel Benedita Terrabuio; Cristiane Alves Villela-Nogueira; Michelle Harriz Braga; Mateus Jorge Nardelli; Luciana Costa Faria; Elze Maria Gomes Oliveira; Vivian Rotman; Maria Beatriz Oliveira; Simone Muniz Carvalho Fernandes da Cunha; MARLONE CUNHA DA SILVA; Liliana Sampaio Costa Mendes; Claudia Alexandra Pontes Ivantes; Liana Codes; Valéria Ferreira de Almeida e Borges; Fabio Heleno de Lima Pace; Mario Guimarães Pessoa; Izabelle Venturini Signorelli; Gabriela Perdomo Coral; PAULO LISBOA BITTENCOURT; Maria Lúcia Gomes Ferraz |
| Source: | Annals of Hepatology, Vol 29, Iss , Pp 101723- (2024) |
| Publisher Information: | Elsevier |
| Publication Year: | 2024 |
| Collection: | Directory of Open Access Journals: DOAJ Articles |
| Subject Terms: | Specialties of internal medicine; RC581-951 |
| Description: | Conflict of interest: No Introduction and Objectives: Primary biliary cholangitis is a chronic and progressive autoimmune liver disease, whose prognosis can be improved by normalizing alkaline phosphatase and bilirubin. While ursodeoxycholic acid (UDCA) is first line standard of care, approximately 40% of patients exhibit incomplete response. We aimed to identify prognostic markers for deep response to UDCA therapy at presentation. Patients / Materials and Methods: Data from the Brazilian Cholestasis Study Group cohort were analyzed retrospectively. Patients were assessed for deep response (defined as normalization of alkaline phosphatase and bilirubin) after 1 year of UDCA treatment. With the purpose of selecting the set of relevant variables related to the deep response for a parsimonious multivariate model, we applied the Varrank algorithm. Additionally, the performance of the UDCA response score in predicting deep response was evaluated. Results and Discussion: A total of 297 patients were analyzed, with 57.2% achieving an adequate response according to the Toronto criteria, while 22.9% reached deep response. Cirrhosis (OR 0.460; 95% CI 0.225-0.942; p=0.034) and elevated baseline alkaline phosphatase levels (OR 0.629; 95% CI 0.513-0.770; p |
| Document Type: | article in journal/newspaper |
| Language: | English |
| Relation: | http://www.sciencedirect.com/science/article/pii/S1665268124005064; https://doaj.org/toc/1665-2681; https://doaj.org/article/f34f6a675812420bbd7ac71bb284ec8a |
| DOI: | 10.1016/j.aohep.2024.101723 |
| Availability: | https://doi.org/10.1016/j.aohep.2024.101723; https://doaj.org/article/f34f6a675812420bbd7ac71bb284ec8a |
| Accession Number: | edsbas.A93A3CB8 |
| Database: | BASE |