Homochiral synthesis of paraconic acid and the biosynthesis of amphotericin B.
| Title: | Homochiral synthesis of paraconic acid and the biosynthesis of amphotericin B. |
|---|---|
| Authors: | James Michael. Crawforth |
| Publication Year: | 1996 |
| Collection: | University of Leicester: Figshare |
| Subject Terms: | IR content |
| Description: | Homochiral (S)-(-)-paraconic acid was synthesised in 18% overall yield from (45)-4-isopropyl-2-oxazolidinone using titanium enolate methodology. Paraconic acid was used to synthesise A-factor. A-factor and analogues were fed to a culture of Streptomyces nodosus however no definitive enhancement, or a decrease in the lag time for the onset of metabolite production was observed. Sodium acetate-d3, [1-13C] and [3-13C]-propionate were fed to a culture of Streptomyces nodosus and label incorporation into amphotericin B of 10-15% was observed. |
| Document Type: | thesis |
| Language: | unknown |
| Relation: | 2381/34068; https://figshare.com/articles/thesis/Homochiral_synthesis_of_paraconic_acid_and_the_biosynthesis_of_amphotericin_B_/10187216 |
| Availability: | https://figshare.com/articles/thesis/Homochiral_synthesis_of_paraconic_acid_and_the_biosynthesis_of_amphotericin_B_/10187216 |
| Rights: | All Rights Reserved |
| Accession Number: | edsbas.A965A457 |
| Database: | BASE |