| Title: |
Cell senescence and the DNA single-strand break damage repair pathway |
| Authors: |
Sarma, Parvathy, A; Abbadie, Corinne; de Launoit, Yvan; Cleri, Fabrizio |
| Contributors: |
Physique - IEMN (PHYSIQUE - IEMN); Institut d’Électronique, de Microélectronique et de Nanotechnologie - UMR 8520 (IEMN); Centrale Lille-Université de Lille-Centre National de la Recherche Scientifique (CNRS)-Université Polytechnique Hauts-de-France (UPHF)-JUNIA (JUNIA); Université catholique de Lille (UCL)-Université catholique de Lille (UCL)-Centrale Lille-Université de Lille-Centre National de la Recherche Scientifique (CNRS)-Université Polytechnique Hauts-de-France (UPHF)-JUNIA (JUNIA); Université catholique de Lille (UCL)-Université catholique de Lille (UCL); Hétérogénéité, Plasticité et Résistance aux Thérapies des Cancers = Cancer Heterogeneity, Plasticity and Resistance to Therapies - UMR 9020 - U 1277 (CANTHER); Institut Pasteur de Lille; Pasteur Network (Réseau International des Instituts Pasteur)-Pasteur Network (Réseau International des Instituts Pasteur)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lille-Centre Hospitalier Régional Universitaire CHU Lille (CHRU Lille)-Centre National de la Recherche Scientifique (CNRS); Projet PEARL Université de Lille "SENESIMEX" Experiments and simulations of radiation-induced cell senescence" |
| Source: |
https://hal.science/hal-04759695 ; 2024. |
| Publisher Information: |
CCSD |
| Publication Year: |
2024 |
| Collection: |
LillOA (HAL Lille Open Archive, Université de Lille) |
| Subject Terms: |
DNA damage; Radiotherapy; DNA repair pathways; Base-excision repair; Single-strand breaks; Radiation-induced stress; Cell senescence; Cell senescence DNA damage Radiotherapy DNA repair pathways Base-excision repair Single-strand breaks Radiation-induced stress; [PHYS]Physics [physics]; [SDV]Life Sciences [q-bio] |
| Description: |
Article non encore soumis ; Cellular senescence is a response to endogenous and exogenous stresses, including telomere dysfunction, oncogene activation and persistent DNA damage. In particular, radiation damage induces oxidative base damage and bond breaking in the DNA double-helix structure, which are treated by dedicated enzymatic repair pathways. In this review we discuss the correlation between senescence and the accumulation of non-repaired single-strand breaks, as it could occur during radiation therapy treatments. Recent experiments of cell irradiation in vitro by high-energy photons showed that single-strand breaks may be preferentially produced at the borders of the irradiated region, thereby inducing senescence, in competition with the apoptosis end-point typically induced by double-strand breaks. Such a peculiar response to radiation damage has been proposed as a possible source of radiation-induced second primary cancers, when such cells with accumulated, non-repaired single-strand breaks evade the senescent state at much later times. The peculiarities of strand-break repair pathways are highlighted, also in relation with the base-excision pathway that repairs several different DNA oxidation defects. |
| Document Type: |
report |
| Language: |
English |
| Availability: |
https://hal.science/hal-04759695; https://hal.science/hal-04759695v1/document; https://hal.science/hal-04759695v1/file/senescence_DNA.pdf |
| Rights: |
https://creativecommons.org/licenses/by-nd/4.0/ ; info:eu-repo/semantics/OpenAccess |
| Accession Number: |
edsbas.A9A3BD03 |
| Database: |
BASE |