| Title: |
Interferon-epsilon is a novel regulator of NK cell responses in the uterus |
| Authors: |
Mayall, JR; Horvat, JC; Mangan, NE; Chevalier, A; McCarthy, H; Hampsey, D; Donovan, C; Brown, AC; Matthews, AY; de Weerd, NA; de Geus, ED; Starkey, MR; Kim, RY; Daly, K; Goggins, BJ; Keely, S; Maltby, S; Baldwin, R; Foster, PS; Boyle, MJ; Tanwar, PS; Huntington, ND; Hertzog, PJ; Hansbro, PM |
| Publisher Information: |
Springer Science and Business Media LLC |
| Publication Year: |
2024 |
| Collection: |
The University of Melbourne: Digital Repository |
| Description: |
The uterus is a unique mucosal site where immune responses are balanced to be permissive of a fetus, yet protective against infections. Regulation of natural killer (NK) cell responses in the uterus during infection is critical, yet no studies have identified uterine-specific factors that control NK cell responses in this immune-privileged site. We show that the constitutive expression of IFNε in the uterus plays a crucial role in promoting the accumulation, activation, and IFNγ production of NK cells in uterine tissue during Chlamydia infection. Uterine epithelial IFNε primes NK cell responses indirectly by increasing IL-15 production by local immune cells and directly by promoting the accumulation of a pre-pro-like NK cell progenitor population and activation of NK cells in the uterus. These findings demonstrate the unique features of this uterine-specific type I IFN and the mechanisms that underpin its major role in orchestrating innate immune cell protection against uterine infection. |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| ISSN: |
1757-4676 |
| Relation: |
https://hdl.handle.net/11343/348496 |
| Availability: |
https://hdl.handle.net/11343/348496 |
| Rights: |
https://creativecommons.org/licenses/by/4.0 ; CC BY |
| Accession Number: |
edsbas.AAA0EC63 |
| Database: |
BASE |