| Title: |
Identification of circulating microRNAs for the differential diagnosis of Parkinson's disease and Multiple System Atrophy |
| Authors: |
Annamaria Vallelunga; Marco Ragusa; Stefania Di Mauro; Tommaso Iannitti; Manuela Pilleri; Roberta Biundo; Luca Weis; Cinzia Di Pietro; Angela De Iuliis; Alessandra Nicoletti; Mario Zappia; Michele Purrello; Angelo Antonini |
| Contributors: |
Vallelunga, Annamaria; Ragusa, Marco; Di Mauro, Stefania; Iannitti, Tommaso; Pilleri, Manuela; Biundo, Roberta; Weis, Luca; Di Pietro, Cinzia; De Iuliis, Angela; Nicoletti, Alessandra; Zappia, Mario; Purrello, Michele; Antonini, Angelo |
| Publisher Information: |
Frontiers Research Foundation |
| Publication Year: |
2014 |
| Collection: |
Padua Research Archive (IRIS - Università degli Studi di Padova) |
| Subject Terms: |
Atypical parkinsonian disorder; Circulating microRNA; Early diagnosi; MicroRNA; Multiple system atrophy; Parkinson's disease |
| Description: |
Background: Parkinson's disease (PD) is a progressive neurodegenerative disorder which may be misdiagnosed with atypical conditions such as Multiple System Atrophy (MSA), due to overlapping clinical features. MicroRNAs (miRNAs) are small non-coding RNAs with a key role in post-transcriptional gene regulation. We hypothesized that identification of a distinct set of circulating miRNAs (cmiRNAs) could distinguish patients affected by PD from MSA and healthy individuals. Results. Using TaqMan Low Density Array technology, we analyzed 754 miRNAs and found 9 cmiRNAs differentially expressed in PD and MSA patients compared to healthy controls. We also validated a set of 4 differentially expressed cmiRNAs in PD and MSA patients vs. controls. More specifically, miR-339-5p was downregulated, whereas miR-223*, miR-324-3p, and mir-24 were upregulated in both diseases. We found cmiRNAs specifically deregulated in PD (downregulation of miR-30c and miR-148b) and in MSA (upregulation of miR-148b). Finally, comparing MSA and PD, we identified 3 upregulated cmiRNAs in MSA serum (miR-24, miR-34b, miR-148b). Conclusions. Our results suggest that cmiRNA signatures discriminate PD from MSA patients and healthy controls and may be considered specific, non-invasive biomarkers for differential diagnosis. © Ragusa, Di Mauro, Iannitti, Pilleri, Biundo, Weis, Di Pietro, De Iuliis, Nicoletti, Zappia, Purrello and Antonini. |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| Relation: |
info:eu-repo/semantics/altIdentifier/wos/WOS:000336956000001; volume:8; journal:FRONTIERS IN CELLULAR NEUROSCIENCE; https://hdl.handle.net/11577/3457736 |
| DOI: |
10.3389/fncel.2014.00156 |
| Availability: |
https://hdl.handle.net/11577/3457736; https://doi.org/10.3389/fncel.2014.00156 |
| Rights: |
info:eu-repo/semantics/openAccess ; license:Creative commons ; license uri:http://creativecommons.org/licenses/by/4.0/ |
| Accession Number: |
edsbas.AB4AC13 |
| Database: |
BASE |