| Title: |
Increasing use of nonsurgical therapy in advanced‐stage oral cavity cancer: A population‐based study |
| Authors: |
Cannon, Richard B.; Sowder, Justin C.; Buchmann, Luke O.; Hunt, Jason P.; Hitchcock, Ying J.; Lloyd, Shane; Grossman, Kenneth F.; Monroe, Marcus M. |
| Source: |
Head & Neck ; volume 39, issue 1, page 82-91 ; ISSN 1043-3074 1097-0347 |
| Publisher Information: |
Wiley |
| Publication Year: |
2016 |
| Collection: |
Wiley Online Library (Open Access Articles via Crossref) |
| Description: |
Background National guidelines support surgical‐based treatment and offer nonsurgical therapy as an alternative for advanced‐stage oral cavity squamous cell carcinoma (SCC). There are limited data evaluating current utilization of these therapies and their survival outcomes. Methods A total of 5856 patients were found in the Surveillance, Epidemiology, and End Results (SEER) database from 1988 to 2008 with resectable advanced‐stage oral cavity SCC tumors. Outcomes were disease‐specific survival (DSS) and overall survival (OS). Results Surgical therapy had significantly improved mean DSS and OS (115 and 71 months, respectively) compared to nonsurgical therapy (63 and 35 months, respectively; p < .001). The use of nonsurgical therapy was significantly associated with the hard palate, and patients who were single, divorced, and black, with T3, T4, and N3 tumors, and the percent utilization has significantly increased from 12% to 20% ( p < .05). Conclusion Utilization of nonsurgical therapy for advanced‐stage oral cavity SCC is increasing and is independently associated with a reduction in survival, as well as patient factors traditionally associated with reduced access to medical care and advanced T and N classifications. © 2016 Wiley Periodicals, Inc. Head Neck 39: 82–91, 2017 |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| DOI: |
10.1002/hed.24542 |
| Availability: |
https://doi.org/10.1002/hed.24542; https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Fhed.24542; https://onlinelibrary.wiley.com/doi/pdf/10.1002/hed.24542 |
| Rights: |
http://onlinelibrary.wiley.com/termsAndConditions#vor |
| Accession Number: |
edsbas.AB5D2D4A |
| Database: |
BASE |