| Title: |
Evaluation of the effects on the QT-interval of 4 artemisinin-based combination therapies with a correction-free and heart rate-free method |
| Authors: |
Funck-Brentano, Christian; Ouologuem, Nouhoum; Duparc, Stephan; Felices, Mathieu; Sirima, Sodiomon, B; Sagara, Issaka; Soulama, Issiaka; Ouédraogo, Jean-Bosco; Beavogui, Abdoul, H; Borghini-Fuhrer, Isabelle; Khan, Yasmin; Djimde, Abdoulaye; Voiriot, Pascal |
| Contributors: |
Unité de Recherche sur les Maladies Cardiovasculaires, du Métabolisme et de la Nutrition = Research Unit on Cardiovascular and Metabolic Diseases (ICAN); Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)-Institut de Cardiométabolisme et Nutrition = Institute of Cardiometabolism and Nutrition CHU Pitié Salpêtrière (IHU ICAN); CHU Pitié-Salpêtrière AP-HP; Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-CHU Pitié-Salpêtrière AP-HP; Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU); Malaria Research and Training Center Bamako, Mali; Université des Sciences, des Techniques et des Technologies de Bamako (USTTB); University of Bamako Mali; PhinC Development; Centre National de Recherche et de Formation sur le Paludisme Ouagadougou, Burkina Faso (CNRFP); Institut de Recherche en Sciences de la Santé (IRSS) / Centre Muraz; Cardiabase-Banook group Nancy; Université de Bamako |
| Source: |
ISSN: 2045-2322. |
| Publisher Information: |
CCSD; Nature Publishing Group |
| Publication Year: |
2019 |
| Subject Terms: |
[SDV.SP.MED]Life Sciences [q-bio]/Pharmaceutical sciences/Medication; [SDV.MHEP.CSC]Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system |
| Description: |
International audience ; Several antimalarial drugs are known to prolong ventricular repolarization as evidenced by QT/QTc interval prolongation. This can lead to Torsades de Pointes, a potentially lethal ventricular arrhythmia. Whether this is the case with artemisinin-based combination therapies (ACTs) remains uncertain. Assessment of the extent of QTc prolongation with antimalarials is hampered by important variations of heart rate during malaria crises and previous studies have reported highly variable values of QTc prolongations with ACTs. We assessed QTc prolongation with four ACTs, using high quality ECG recording and measurement techniques, during the first episode of malaria in 2,091 African patients enrolled in the WANECAM study which also monitored clinical safety. Using an original and robust method of QTc assessment, independent from heart rate changes and from the method of QT correction, we were able to accurately assess the extent of mean maximum QTc prolongation with the four ACTs tested. There was no evidence of proarrhythmia with any treatment during the study although dihydroartemisinin-piperaquine, artesunate-amodiaquine and artemether-lumefantrine significantly prolonged QTc. The extent of prolongation of ventricular repolarization can be accurately assessed in studies where heart rate changes impede QTc assessment. |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| DOI: |
10.1038/s41598-018-37113-5 |
| Availability: |
https://hal.sorbonne-universite.fr/hal-02017652; https://hal.sorbonne-universite.fr/hal-02017652v1/document; https://hal.sorbonne-universite.fr/hal-02017652v1/file/s41598-018-37113-5%281%29.pdf; https://doi.org/10.1038/s41598-018-37113-5 |
| Rights: |
info:eu-repo/semantics/OpenAccess |
| Accession Number: |
edsbas.AB6BD839 |
| Database: |
BASE |