| Title: |
Molecular and functional characterisation of the zebrafish (Danio rerio) PEPT1-type peptide transporter |
| Authors: |
VERRI T; KOTTRA G; ROMANO A; PERIC M; MAFFIA M; BOLL M; DANIEL H; STORELLI C.; TISO, NATASCIA; ARGENTON, FRANCESCO |
| Contributors: |
Verri, T; Kottra, G; Romano, A; Tiso, Natascia; Peric, M; Maffia, M; Boll, M; Argenton, Francesco; Daniel, H; Storelli, C. |
| Publisher Information: |
ELSEVIER SCIENCE BV, PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS |
| Publication Year: |
2003 |
| Collection: |
Padua Research Archive (IRIS - Università degli Studi di Padova) |
| Subject Terms: |
zebrafish; peptide transporter; pept1 gene |
| Description: |
We report the molecular and functional characterisation of a novel peptide transporter from zebrafish, orthologue to mammalian and avian PEPT1. Zebrafish PEPT1 is a low-affinity/high-capacity system. However, in contrast to higher vertebrate counterparts in which maximal transport activity is independent of extracellular pH, zebrafish PEPT1 maximal transport rates unexpectedly increase at alkaline extracellular pH. Zebrafish pept1 is highly expressed in the proximal intestine since day 4 post-fertilisation, thus preceding functional maturation of the gut, first feeding and complete yolk resorption. Zebrafish PEPT1 might help to understand the evolutionary and functional relationships among vertebrate peptide transporters. Moreover, zebrafish pept1 can be a useful marker for screening mutations that affect gut regionalisation, differentiation and morphogenesis. |
| Document Type: |
article in journal/newspaper |
| File Description: |
STAMPA |
| Language: |
English |
| Relation: |
info:eu-repo/semantics/altIdentifier/pmid/12914936; info:eu-repo/semantics/altIdentifier/wos/WOS:000184818400023; volume:549; issue:1-3; firstpage:115; lastpage:122; journal:FEBS LETTERS; https://hdl.handle.net/11577/2459161; http://www.ncbi.nlm.nih.gov/pubmed/12914936 |
| DOI: |
10.1016/S0014-5793(03)00759-2 |
| Availability: |
https://hdl.handle.net/11577/2459161; https://doi.org/10.1016/S0014-5793(03)00759-2; http://www.ncbi.nlm.nih.gov/pubmed/12914936 |
| Rights: |
info:eu-repo/semantics/openAccess ; license:Accesso gratuito |
| Accession Number: |
edsbas.AB82CDC0 |
| Database: |
BASE |