| Title: |
Androgen receptors are acquired by healthy postmenopausal endometrial epithelium and their subsequent loss in endometrial cancer is associated with poor survival |
| Authors: |
Kamal, A. M.; Bulmer, J. N.; DeCruze, S. B.; Stringfellow, Helen F.; Martin-Hirsch, Pierre Leonard; Hapangama, Dharani |
| Publication Year: |
2016 |
| Collection: |
Lancaster University: Lancaster Eprints |
| Description: |
background: Endometrial cancer (EC) is a hormone-driven disease, and androgen receptor (AR) expression in high-grade EC (HGEC) and metastatic EC has not yet been described. methods: The expression pattern and prognostic value of AR in relation to oestrogen (ERα and ERβ) and progesterone (PR) receptors, and the proliferation marker Ki67 in all EC subtypes (n=85) were compared with that of healthy and hyperplastic endometrium, using immunohistochemisty and qPCR. results: Compared with proliferative endometrium, postmenopausal endometrtial epithelium showed significantly higher expression of AR (P |
| Document Type: |
article in journal/newspaper |
| Language: |
unknown |
| ISSN: |
0007-0920 |
| Relation: |
Kamal, A. M. and Bulmer, J. N. and DeCruze, S. B. and Stringfellow, Helen F. and Martin-Hirsch, Pierre Leonard and Hapangama, Dharani (2016) Androgen receptors are acquired by healthy postmenopausal endometrial epithelium and their subsequent loss in endometrial cancer is associated with poor survival. British Journal of Cancer, 114. pp. 688-696. ISSN 0007-0920 |
| Availability: |
https://eprints.lancs.ac.uk/id/eprint/80989/ |
| Accession Number: |
edsbas.AB870092 |
| Database: |
BASE |