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Impaired thymic AIRE expression underlies autoantibodies against type I IFNs in humans with inborn errors of the alternative NF-kB pathway

Title: Impaired thymic AIRE expression underlies autoantibodies against type I IFNs in humans with inborn errors of the alternative NF-kB pathway
Authors: Voyer, Tom Le; Gervais, Adrian; Rosain, Jérémie; Parent, Audrey; Cederholm, Axel; Rinchai, Darawan; Bizien, Lucy; Hancioglu, Gonca; Philippot, Quentin; Gueye, Mame Sokhna; Luxman, Majistor Raj; Renkilaraj, Maglorius; Ogishi, Masato; Soudée, Camille; Migaud, Mélanie; Rozenberg, Flore; Momenilandi, Mana; Riller, Quentin; Imberti, Luisa; Delmonte, Ottavia; Müller, Gabriele; Keller, Bärbel; Orrego, Julio; Gallego, William Alexander; Rubin, Tamar; Emiroglu, Melike; Parvaneh, Nima; Eriksson, Daniel; Aranda-Guillen, Maribel; Berrios, David I; Vong, Linda; Katelaris, Connie H; Mustillo, Peter; Rädler, Johannes; Bohlen, Jonathan; Celik, Jale Bengi; Astudillo, Camila; Winter, Sarah; Guichard, Audrey; Béziat, Vivien; Bustamante, Jacinta; Pan-Hammarström, Qiang; Zhang, Yu; Rosen, Lindsey B; Holland, Steve M; Kenney, Heather; Boztuğ, Kaan; Mahlaoui, Nizar; Latour, Sylvain; Abraham, Roshini
Publisher Information: Authorea, Inc.
Publication Year: 2023
Collection: The Winnower (via CrossRef)
Description: Patients with inborn errors of the alternative NF-κB pathway have low thymic AIRE expression, leading to the development of auto-Abs neutralizing type I IFNs, and severe viral diseases.
Document Type: other/unknown material
Language: unknown
DOI: 10.22541/au.167330741.18394805/v1
Availability: https://doi.org/10.22541/au.167330741.18394805/v1
Accession Number: edsbas.AB942752
Database: BASE