| Title: |
Epidemiological and clinical study of microsporidiosis in French kidney transplant recipients from 2005 to 2019: TRANS‐SPORE registry |
| Authors: |
Dumond, Clément; Aulagnon, Florence; Etienne, Isabelle; Heng, Anne‐elisabeth; Bougnoux, Marie‐elisabeth; Favennec, Loic; Kamar, Nassim; Iriart, Xavier; Pereira, Bruno; Buchler, Matthias; Desoubeaux, Guillaume; Kaminski, Hannah; Lussac‐sorton, Florian; Gargala, Gilles; Anglicheau, Dany; Poirier, Philippe; Scemla, Anne; Garrouste, Cyril; Labbe, Franck; Damiani, Céline; Le Govic, Yohann; Totet, Anne; de Gentile, Ludovic; Lemoine, Jean‐philippe; Bellanger, Anne Pauline; Accoceberry, Isabelle; Delhaes, Laurence; Gabriel, Frédéric; Millet, Pascal; Le Gal, Solène; Nevez, Gilles; Bonhomme, Julie; Capitaine, Agathe; Demar, Magalie; Moniot, Maxime; Nourrisson, Céline; Angebault, Cécile; Botterel, Françoise; Foulet, Françoise; Basmaciyan, Louise; Dalle, Frédéric; Valot, Stéphane; Desbois‐nogard, Nicole; Robert, Gladys; Deleplancque, Anne‐sophie; Frealle, Emilie; Leroy, Jordan; Ajzenberg, Daniel; Durieux, Marie‐fleur; Chapey‐picq, Emmanuelle; Dupont, Damien; Menotti, Jean; Rabodonirina, Meja; Lollivier, Coralie; Bastien, Patrick; Debourgogne, Anne; Machouart, Marie; Lavergne, Rose‐anne; Morio, Florent; Delaunay, Pascal; Pomares, Christelle; Simon, Loïc; Sasso, Milène; Argy, Nicolas; Houze, Sandrine; Yera, Hélène; Dannaoui, Eric; Sitterle, Emilie; Kapel, Nathalie; Tantaoui, Ilhame; Thellier, Marc; Belkadi, Ghania Belkacem; Moreno‐sabater, Alicia; Hamane, Samia; Nicolas, Muriel; Perraud, Estelle; Chemla, Cathy; Villena, Isabelle; Autier, Brice; Costa, Damien; Flori, Pierre; Brunet, Julie; Berry, Antoine; Chesnay, Adélaïde; Artur, Fabienne; Verdurme, Laura; Foulquier, Jean‐baptiste; Prigent, Gwenole; Chatelain, Rémi; Lesthelle, Sophie |
| Contributors: |
CHU Clermont-Ferrand; Hôpital Necker - Enfants Malades AP-HP; Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP); CHU Rouen; Normandie Université (NU); Institut Toulousain des Maladies Infectieuses et Inflammatoires (Infinity); Université Toulouse III - Paul Sabatier (UT3); Communauté d'universités et établissements de Toulouse (Comue de Toulouse)-Communauté d'universités et établissements de Toulouse (Comue de Toulouse)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS); Centre Hospitalier Universitaire de Toulouse (CHU Toulouse); CHU Trousseau Tours; Centre Hospitalier Régional Universitaire de Tours (CHRU Tours); Centre Hospitalier Universitaire de Bordeaux (CHU Bordeaux); Infection Inflammation et Interaction Hôtes Pathogènes CHU Clermont-Ferrand (3IHP); Direction de la Recherche Clinique et de l’Innovation CHU Clermont-Ferrand (DRCI); CHU Clermont-Ferrand-CHU Clermont-Ferrand; Université Clermont Auvergne (UCA); Groupe d'Étude des Interactions Hôte-Pathogène (GEIHP); Université d'Angers (UA); SFR UA 4208 Interactions Cellulaires et Applications Thérapeutiques (ICAT); Laboratoire de Parasitologie et Mycologiede CHRU Brest; Centre Hospitalier Régional Universitaire de Brest (CHRU Brest); Aliments Bioprocédés Toxicologie Environnements (ABTE); Université de Caen Normandie (UNICAEN); Normandie Université (NU)-Normandie Université (NU)-Université de Rouen Normandie (UNIROUEN); Centre hospitalier universitaire de Poitiers = Poitiers University Hospital (CHU de Poitiers La Milétrie ); Écologie et biologie des interactions UMR 7267 (EBI Poitiers ); Université de Poitiers = University of Poitiers (UP)-Centre National de la Recherche Scientifique (CNRS); Hôpital universitaire Robert Debré Reims (CHU Reims); Epidémiosurveillance de protozooses à transmission alimentaire et vectorielle (ESCAPE); Université de Reims Champagne-Ardenne (URCA)-Université de Rouen Normandie (UNIROUEN); Normandie Université (NU)-Normandie Université (NU)-Agence nationale de sécurité sanitaire de l'alimentation, de l'environnement et du travail (ANSES) |
| Source: |
ISSN: 1398-2273. |
| Publisher Information: |
CCSD; Wiley |
| Publication Year: |
2021 |
| Collection: |
Université de Poitiers: Publications de nos chercheurs.ses (HAL) |
| Subject Terms: |
fumagillin; immunosuppressive regimen; kidney transplantation; microsporidiosis; MESH: Enterocytozoon; MESH: Humans; MESH: Kidney Transplantation; MESH: Male; MESH: Microsporidiosis; MESH: Middle Aged; MESH: Registries; MESH: Spores; Fungal; [SDV]Life Sciences [q-bio] |
| Description: |
International audience ; IntroductionMicrosporidiosis is an emerging opportunistic infection in renal transplantation (RT) recipients. We aimed to describe its clinical presentation and treatment.Materials and methodsWe collected microsporidiosis cases identified in RT recipients between 2005 and 2019 in six French centers from the Crystal, Divat and Astre prospective databases.ResultsWe report 68 RT recipients with intestinal microsporidiosis; the patients were predominantly male (61.8%), with a median age of 58 (46–69) years. Infection occurred at a median time of 3 (0.8–6.8) years posttransplant. Only Enterocytozoon bieneusi was found. Microsporidiosis manifested as diarrhea (98.5% of patients) with weight loss (72.1%) and acute renal injury (57.4%) without inflammatory biological parameters. The therapeutic approaches were no treatment (N = 9), reduction of the immunosuppressive regimen (∆IS) (N = 22), fumagillin alone (N = 9), fumagillin and ∆IS (N = 19), and albendazole or nitazoxanide and ∆IS (N = 9). Overall clinical remission was observed in 60 patients (88.2%). We observed no acute kidney rejection, renal transplant failure, or death within 6 months after microsporidiosis.ConclusionE. bieneusi is an underestimated opportunistic pathogen in RT recipients, and infection with E. bieneusi leads to diarrhea with important dehydration and acute renal injury. The treatment is based on the reduction of the immunosuppressive regimen and the administration of fumagillin if available. |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| Relation: |
info:eu-repo/semantics/altIdentifier/pmid/34324771; PUBMED: 34324771 |
| DOI: |
10.1111/tid.13708 |
| Availability: |
https://univ-angers.hal.science/hal-03419373; https://doi.org/10.1111/tid.13708 |
| Accession Number: |
edsbas.ABA316DF |
| Database: |
BASE |