| Title: |
Dependency of R-2 and R-2* relaxation on Gd-DTPA concentration in arterial blood:Influence of hematocrit and magnetic field strength |
| Authors: |
van Dorth, Danielle; Venugopal, Krishnapriya; Poot, Dirk H. J.; Hirschler, Lydiane; de Bresser, Jeroen; Smits, Marion; Hernandez-Tamames, Juan A.; Debacker, Clement S.; van Osch, Matthias J. P. |
| Source: |
van Dorth, D, Venugopal, K, Poot, D H J, Hirschler, L, de Bresser, J, Smits, M, Hernandez-Tamames, J A, Debacker, C S & van Osch, M J P 2022, 'Dependency of R-2 and R-2* relaxation on Gd-DTPA concentration in arterial blood : Influence of hematocrit and magnetic field strength', NMR in Biomedicine, vol. 35, no. 5, e4653. https://doi.org/10.1002/nbm.4653 |
| Publication Year: |
2022 |
| Description: |
Dynamic susceptibility contrast (DSC) MRI is clinically used to measure brain perfusion by monitoring the dynamic passage of a bolus of contrast agent through the brain. For quantitative analysis of the DSC images, the arterial input function is required. It is known that the original assumption of a linear relation between the R-2((*)) relaxation and the arterial contrast agent concentration is invalid, although the exact relation is as of yet unknown. Studying this relation in vitro is time-consuming, because of the widespread variations in field strengths, MRI sequences, contrast agents, and physiological conditions. This study aims to simulate the R-2((*)) versus contrast concentration relation under varying physiological and technical conditions using an adapted version of an open-source simulation tool. The approach was validated with previously acquired data in human whole blood at 1.5 T by means of a gradient-echo sequence (proof-of-concept). Subsequently, the impact of hematocrit, field strength, and oxygen saturation on this relation was studied for both gradient-echo and spin-echo sequences. The results show that for both gradient-echo and spin-echo sequences, the relaxivity increases with hematocrit and field strength, while the hematocrit dependency was nonlinear for both types of MRI sequences. By contrast, oxygen saturation has only a minor effect. In conclusion, the simulation setup has proven to be an efficient method to rapidly calibrate and estimate the relation between R-2((*)) and gadolinium concentration in whole blood. This knowledge will be useful in future clinical work to more accurately retrieve quantitative information on brain perfusion. |
| Document Type: |
article in journal/newspaper |
| File Description: |
application/pdf |
| Language: |
English |
| ISSN: |
0952-3480; 1099-1492 |
| Relation: |
info:eu-repo/semantics/altIdentifier/pmid/34816501; info:eu-repo/semantics/altIdentifier/wos/000721851300001; info:eu-repo/semantics/altIdentifier/pissn/0952-3480; info:eu-repo/semantics/altIdentifier/eissn/1099-1492 |
| DOI: |
10.1002/nbm.4653 |
| Availability: |
https://pure.eur.nl/en/publications/fb359842-a165-4372-9fd5-7db13c2c0d84; https://doi.org/10.1002/nbm.4653; https://pure.eur.nl/ws/files/50362734/NMR_in_Biomedicine_2021_Dorth_Dependency_of_R2_and_R2_relaxation_on_Gd_DTPA_concentration_in_arterial_blood_.pdf; https://www.scopus.com/pages/publications/85119702473 |
| Rights: |
info:eu-repo/semantics/openAccess ; http://creativecommons.org/licenses/by-nc/4.0/ |
| Accession Number: |
edsbas.ABD61FF5 |
| Database: |
BASE |