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Increased risk of cardiovascular disease (CVD) with age in HIV-positive men: a comparison of the D:A:D CVD risk equation and general population CVD risk equations.

Title:	Increased risk of cardiovascular disease (CVD) with age in HIV-positive men: a comparison of the D:A:D CVD risk equation and general population CVD risk equations.
Authors:	Petoumenos K1; Reiss P; Ryom L; Rickenbach M; Sabin CA; El Sadr W; d'Arminio Monforte A; Phillips AN; De Wit S; Kirk O; Dabis F; Pradier C; Lundgren JD; Law MG; D:A:D study group; Powderly B; Shortman N; Moecklinghoff C; Reilly G; Franquet X; Kamara D; Smith C; Phillips A; Mocroft A; Tverland J; Mansfeld M; Nielsen J; Raben D; Lundgren J; Brandt R; Fanti I; Krum E; Hillebregt M; Geffard S; Sundström A; Delforge M; Fontas E; Torres F; McManus H; Wright S; Kjær J; Sjøl A; Meidahl P; Helweg Larsen J; Iversen J; Ross M; Fux C; Morlat P; Moranne O; Kesselring A; Weber R; Friis Møller N; Kowalska J; Sabin C; Law M; Bruyand M; Bower M; Fätkenheuer G; Donald A; Grulich A; Zaheri S; Gras L; Prins J; Kuijpers T; Scherpbier H; van der Meer J; Wit F; Godfried M; van der Poll T; Nellen F; Lange J; Geerlings S; van Vugt M; Pajkrt D; Bos J; van der Valk M; Grijsen M; Wiersinga W; Goorhuis A; Hovius J; Lowe S; Lashof A; Posthouwer D; Pronk M; Ammerlaan H; van der Ende M; de Vries Sluijs T; Schurink C; Nouwen J; Verbon A; Rijnders B; van Gorp E; van der Feltz M; Driessen G; van A; Branger J; Haag D; Schippers E; van Nieuwkoop C; van Elzakker E; Groeneveld P; Bouwhuis J; Soetekouw R; ten Kate R; Kroon F; van Dissel J; Arend S; de Boer M; Jolink H; Vollaard H; Bauer M; den Hollander J; Pogany K; van Twillert G; Kortmann W; Cohen Stuart J; Diederen B; Leyten E; Gelinck L; Kootstra G; Delsing C; Brinkman K; Blok W; Frissen P; Schouten W; van den Berk G; van Kasteren M; Brouwer A; Veenstra J; Lettinga K; Mulder J; Vrouenraets S; Lauw F; van Goyen; van Eeden A; Verhagen D; Sprenger H; Doedens R; Scholvinck E; van S; Bierman W; Koopmans P; Keuter M; van der Ven A; ter Hofstede H; Dofferhoff A; Warris A; van Crevel R; Hoepelman A; Mudrikova T; Schneider M; Ellerbroek P; Oosterheert J; Arends J; Wassenberg M; Barth R; van Agtmael M; Perenboom R; Claessen F; Bomers M; Peters E; Geelen S; Wolfs T; Bont L; Richter C; van der Berg J; Gisolf E; van den Berge M; Stegeman A; van Vonderen M; van Houte D; Weijer S; el Moussaoui R; Winkel C; Muskiet F; Voigt R; Chêne G; Lawson Ayayi S; Thiébaut R; Bonnal F; Bonnet F; Bernard N; Caunègre L; Cazanave C; Ceccaldi J; Chambon D; Chossat I; Dauchy F; De Witte S; Dupon M; Duffau P; Dutronc H; Farbos S; Gaborieau V; Gemain M; Gerard Y; Greib C; Hessamfar M; Lacoste D; Lataste P; Lafarie S; Lazaro E; Malvy D; Meraud J; Mercié P; Monlun E; Neau D; Ochoa A; Pellegrin J; Pistone T; Ragnaud J; Receveur M; Tchamgoué S; Vandenhende M; Viallard J; Moreau J; Pellegrin I; Fleury H; Lafon M; Masquelier B; Trimoulet P; Breilh D; Haramburu F; Miremont Salamé G; Blaizeau M; Decoin M; Delaune J; Delveaux S; D'Ivernois C; Hanapier C; Leleux O; Uwamaliya Nziyumvira B; Sicard X; Palmer G; Touchard D; Petoumenos K; Bendall C; Moore R; Edwards S; Hoy J; Watson K; Roth N; Nicholson J; Bloch M; Franic T; Baker D; Vale R; Carr A; Cooper D; Chuah J; Ngieng M; Nolan D; Skett J; Calvo G; Mateu S; Domingo P; A. M; Gatell J; Del Cacho E; Cadafalch J; Fuster M; Codina C; Sirera G; Vaqué A; Clumeck N; Necsoi C; Gennotte A; Gerard M; Kabeya K; Konopnicki D; Libois A; Martin C; Payen M; Semaille P; Van Laethem Y; Neaton J; Bartsch G; Thompson G; Wentworth D; Luskin Hawk R; Telzak E; Abrams D; Cohn D; Markowitz N; Arduino R; Mushatt D; Friedland G; Perez G; Tedaldi E; Fisher E; Gordin F; Crane L; Sampson J; Baxter J; Cozzi Lepri A; Grint D; Podlekareva D; Peters L; Reekie J; Fischer A; Losso M; Elias C; Ramos JM; Vetter N; Zangerle R; Karpov I; Vassilenko A; Mitsura V; Suetnov O; Colebunders R; Vandekerckhove L; Hadziosmanovic V; Kostov K; Begovac J; Machala L; Jilich D; Sedlacek D; Kronborg G; Benfield T; Larsen M; Gerstoft J; Katzenstein T; Hansen A.; Skinhøj P; Pedersen C; Ostergaard L; Zilmer K; Smidt J; Ristola M; Katlama C; Viard J.; Girard P.; Livrozet J; Vanhems P; Bernard C; Rockstroh J; Schmidt R; van Lunzen J; Degen O; Stellbrink H; Staszewski S; Goethe JW; Bickel M; Kosmidis J; Gargalianos P; Xylomenos G; Perdios J; Panos G; Filandras A; Karabatsaki E; Sambatakou H; Banhegyi D; Mulcahy F; Yust I; Turner D; Burke M; Pollack S; Hassoun G; Maayan S; Vella S; Esposito R; Mazeu I; Mussini C; Arici C; Pristera R; Mazzotta F; Gabbuti A; Vullo V; Lichtner M; Chirianni A; Montesarchio E; Gargiulo M; Cotugno AD; Antonucci G; Testa A; Narciso P; Vlassi C; Zaccarelli M; Lazzarin A; Castagna A; Gianotti N; Galli M; Ridolfo A; Sacco L; Rozentale B; Zeltina I; Chaplinskas S; Hemmer R; Staub T; Ormaasen V; Maeland A; Bruun J; Knysz B; Gasiorowski J; Horban A; Bakowska E; Grzeszczuk A; Flisiak R; Boron Kaczmarska A; Pynka M; Parczewski M; Beniowski M; Mularska E; Trocha H; Jablonowska E; Malolepsza E; Wojcik K; Antunes F; Doroana M; Caldeira L; Mansinho K; Maltez F; Duiculescu D; Rakhmanova A; Zakharova N; Buzunova S; Jevtovic D; Mokráš M; Staneková D; Tomazic J; González Lahoz J; Soriano V; Labarga P; Medrano J; Moreno S; Rodriguez J; Clotet B; Jou A; Paredes R; Tural C; Puig J; Bravo I; M. J; Gutierrez M; Mateo G; Sambeat M; Karlsson A; Flamholc L; Ledergerber B; Francioli P; Cavassini M; Hirschel B; Boffi E; Furrer H; Battegay M; Elzi L; Kravchenko E; Chentsova N; Frolov V; Kutsyna G; Servitskiy S; Krasnov M; Barton S; Johnson A; Mercey D; Johnson M; Murphy M; Weber J; Scullard G; Fisher M; Leen C; Morfeldt L; Thulin G; Åkerlund B; Koppel K; Håkangård C; Moroni M; Angarano G; Antinori A; Armignacco O; Castelli F; Cauda R; Di Perri G; Iardino R; Ippolito G; Perno C; von Schloesser F; Viale P; Ceccherini Silberstein F; Girardi E; Lo Caputo S; Puoti M; Andreoni M; Ammassari A; d'rminio Monforte A; Balotta C; Bonfanti P; Bonora S; Borderi M; Capobianchi M; Cingolani A; Cinque P; De Luca A; Di Biagio A; Gori A; Guaraldi G; Lapadula G; Caputo S; Madeddu G; Maggiolo F; Marchetti G; Marcotullio S; Monno L; Roldan E; Rusconi S; Cicconi P; Formenti T; Galli L; Lorenzini P; Giacometti A; Costantini A; Santoro C; Suardi C; Vanino E; Verucchi G; Quiros Roldan E; Minardi C; Quirino T; Abeli C; Manconi P; Piano P; Sighinolfi L; Segala D; Cassola G; Viscoli G; Alessandrini A; Piscopo R; Mazzarello G; Mastroianni C; Belvisi V; Caramma I; Castelli A; Rizzardini G; Piolini R; Salpietro S; Carenzi L; Moioli M; Puzzolante C; Abrescia N; Guida M; Onofrio M; Baldelli F; Francisci D; Parruti G; Ursini T; Magnani G; Ursitti M; d'Avino A; Gallo L; Nicastri E; Acinapura R; Capozzi M; Libertone R; Tebano G; Cattelan A; Mura M; Caramello P; Orofino G; Sciandra M; Pellizzer G; Manfrin V; Caissotti C; Dellamonica P; Bernard E; Cua E; De Salvador Guillouet F; Durant J; Ferrando S; Mondain Miton V; Naqvi A; Perbost I; Prouvost Keller B; Pillet S; Pugliese P; Rahelinirina V; Roger P; Dollet K; Aubert V; Barth J; Bernasconi E; Böni J; Bucher H; Burton Jeangros C; Calmy A; Egger M; Fehr J; Fellay J; Gorgievski M; Günthard H; Haerry D; Hasse B; Hirsch H; Hösli I; Kahlert C; Kaiser L; Keiser O; Klimkait T; Kovari H; Martinetti G; de Tejada B; Metzner K; Müller N; Nadal D; Pantaleo G; Rauch A; Regenass S; Rudin C; Schmid P; Schultze D; Schöni Affolter F; Schüpbach J; Speck R; Taffé P; Tarr P; Telenti A; Trkola A; Vernazza P; Yerly S.; VECCHIET, Jacopo; FALASCA, KATIA
Contributors:	Petoumenos, K1; Reiss, P; Ryom, L; Rickenbach, M; Sabin, Ca; El Sadr, W; d'Arminio Monforte, A; Phillips, An; De Wit, S; Kirk, O; Dabis, F; Pradier, C; Lundgren, Jd; Law, Mg; D:A:D study, Group; Powderly, B; Shortman, N; Moecklinghoff, C; Reilly, G; Franquet, X; Kamara, D; Smith, C; Phillips, A; Mocroft, A; Tverland, J; Mansfeld, M; Nielsen, J; Raben, D; Lundgren, J; Brandt, R; Fanti, I; Krum, E; Hillebregt, M; Geffard, S; Sundström, A; Delforge, M; Fontas, E; Torres, F; Mcmanus, H; Wright, S; Kjær, J; Sjøl, A; Meidahl, P; Helweg Larsen, J; Iversen, J; Ross, M; Fux, C; Morlat, P; Moranne, O; Kesselring, A; Weber, R; Friis Møller, N; Kowalska, J; Sabin, C; Law, M; Bruyand, M; Bower, M; Fätkenheuer, G; Donald, A; Grulich, A; Zaheri, S; Gras, L; Prins, J; Kuijpers, T; Scherpbier, H; van der Meer, J; Wit, F; Godfried, M; van der Poll, T; Nellen, F; Lange, J; Geerlings, S; van Vugt, M
Publication Year:	2014
Collection:	ARUd'A - Archivio Istituzionale della ricerca dell'università Chieti-Pescara (IRIS)
Description:	The aim of the study was to statistically model the relative increased risk of cardiovascular disease (CVD) per year older in Data collection on Adverse events of anti-HIV Drugs (D:A:D) and to compare this with the relative increased risk of CVD per year older in general population risk equations. METHODS: We analysed three endpoints: myocardial infarction (MI), coronary heart disease (CHD: MI or invasive coronary procedure) and CVD (CHD or stroke). We fitted a number of parametric age effects, adjusting for known risk factors and antiretroviral therapy (ART) use. The best-fitting age effect was determined using the Akaike information criterion. We compared the ageing effect from D:A:D with that from the general population risk equations: the Framingham Heart Study, CUORE and ASSIGN risk scores. RESULTS: A total of 24 323 men were included in analyses. Crude MI, CHD and CVD event rates per 1000 person-years increased from 2.29, 3.11 and 3.65 in those aged 40-45 years to 6.53, 11.91 and 15.89 in those aged 60-65 years, respectively. The best-fitting models included inverse age for MI and age + age(2) for CHD and CVD. In D:A:D there was a slowly accelerating increased risk of CHD and CVD per year older, which appeared to be only modest yet was consistently raised compared with the risk in the general population. The relative risk of MI with age was not different between D:A:D and the general population. CONCLUSIONS: We found only limited evidence of accelerating increased risk of CVD with age in D:A:D compared with the general population. The absolute risk of CVD associated with HIV infection remains uncertain.
Document Type:	article in journal/newspaper
File Description:	STAMPA
Language:	English
Relation:	info:eu-repo/semantics/altIdentifier/wos/WOS:000344385400003; volume:15; issue:10; firstpage:595; lastpage:603; numberofpages:9; journal:HIV MEDICINE; https://hdl.handle.net/11564/603524
Availability:	https://hdl.handle.net/11564/603524
Accession Number:	edsbas.AC384CDC
Database:	BASE