| Title: |
The Ameliorating Effect of Lizhong-Tang on Antibiotic-Associated Imbalance in the Gut Microbiota in Mouse |
| Authors: |
Hye-Ri Ahn; Do Hwi Park; Myoung-Sook Shin; Quynh Nhu Nguyen; Jun Yeon Park; Dong-Wook Kim; Ki Sung Kang; Hye Lim Lee |
| Source: |
Applied Sciences ; Volume 12 ; Issue 14 ; Pages: 6943 |
| Publisher Information: |
Multidisciplinary Digital Publishing Institute |
| Publication Year: |
2022 |
| Collection: |
MDPI Open Access Publishing |
| Subject Terms: |
herbal medicine; Lizhong-tang; gut microbiota; anti-inflammatory |
| Description: |
Some herbal medicines have anti-inflammatory and anti-diarrheal effects. This study analyzed the modulating effect of gut microbiota of anti-inflammatory herbal medicines on antibiotic-associated diarrhea (AAD). The anti-inflammatory effects of 10 herbal medicines and Lizhong-tang active compounds were studied by measuring the nitric oxide production in an in vitro experiment. This was followed by an in vivo experiment in which the anti-diarrheal effects of Lizhong-tang and Magnolia officinalis in a lincomycin-induced AAD mouse model were measured. Changes in the intestinal microflora were observed using terminal restriction fragment length polymorphism analysis. Both Lizhong-tang and M. officinalis were effective against AAD, with Lizhong-tang’s anti-diarrheal effects being particularly effective. In addition, the active compounds of Lizhong-tang, liquiritin and 6-gingerol, inhibited the expression of inducible nitric oxide synthase and cyclooxygenase-2, thus showing an anti-inflammatory effect. Gut microbiota analysis showed that Lizhong-tang could alter the composition of the gut microbiota and ameliorated imbalance in the gut microbiota in a lincomycin-induced AAD mouse model. |
| Document Type: |
text |
| File Description: |
application/pdf |
| Language: |
English |
| Relation: |
Applied Biosciences and Bioengineering; https://dx.doi.org/10.3390/app12146943 |
| DOI: |
10.3390/app12146943 |
| Availability: |
https://doi.org/10.3390/app12146943 |
| Rights: |
https://creativecommons.org/licenses/by/4.0/ |
| Accession Number: |
edsbas.AC51645D |
| Database: |
BASE |