| Title: |
Indeterminate rapid HIV-1 test results among antenatal and postnatal mothers |
| Authors: |
Matemo, D; Kinuthia, J; John, F; Chung, M; Farquhar, C; Stewart, G John; Kiarie, J |
| Publication Year: |
2008 |
| Collection: |
University of Nairobi Digital Repository |
| Subject Terms: |
Indeterminate; HIV; Rapid; ELISA; test |
| Description: |
Summary: The sensitivity and specificity of rapid HIV-1 tests may be altered during pregnancy and postpartum. We conducted a study to determine the prevalence and correlates of false-positive Abbott DetermineTM and false-negative Uni-GoldTM rapid HIV-1 test results among antenatal and postnatal mothers attending a primary care clinic in Nairobi, Kenya. Mothers were tested for HIV-1 using Abbott DetermineTM and non-reactive results were considered HIV-1 antibody negative. Reactive samples by Determine were re-tested by Uni-GoldTM. Vironostika HIV-1 and Uni-FORM II Enzyme-linked immunosorbent assays were used to confirm samples that had positive Abbott DetermineTM and negative Uni-GoldTM. Among 2311 women who accepted HIV-1 testing, 1238 (54%) were tested antenatallyand 1073 (46%) were tested postnatally. Of tested women, 274 (12%) women were reactive by Abbott DetermineTM and on retesting with Uni-GoldTM 30 (11%) had indeterminate results. The prevalence of indeterminate results was significantly higher in antenatal women than in postnatal women (2% versus 1%,P¼ 0.03). In conclusion, indeterminate rapid HIV-1 test results are more common in the antenatal period and appropriate safeguards to confirm HIV-1 infection status should be implemented in antenatal programmes. |
| Document Type: |
article in journal/newspaper |
| File Description: |
application/pdf |
| Language: |
English |
| Relation: |
International Journal of STD & AIDS Volume 20 November 2009; http://hdl.handle.net/11295/10412; http://www.ncbi.nlm.nih.gov/pubmed/19875832 |
| Availability: |
http://hdl.handle.net/11295/10412; http://www.ncbi.nlm.nih.gov/pubmed/19875832 |
| Accession Number: |
edsbas.AC658B3A |
| Database: |
BASE |