| Title: |
A new perspective on tumor progression: Evolution via selection for function |
| Authors: |
Thomas, Frédéric; Degregori, James; Marusyk, Andriy; Dujon, Antoine, M; Ujvari, Beata; Capp, Jean-Pascal; Gatenby, Robert; Nedelcu, Aurora |
| Contributors: |
Maladies infectieuses et vecteurs : écologie, génétique, évolution et contrôle (MIVEGEC); Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD Occitanie )-Université de Montpellier (UM); University of Colorado Anschutz Medical Campus Aurora; H. Lee Moffitt Cancer Center and Research Institute; Deakin University Waurn Ponds; Toulouse Biotechnology Institute (TBI); Institut National des Sciences Appliquées - Toulouse (INSA Toulouse); Institut National des Sciences Appliquées (INSA)-Communauté d'universités et établissements de Toulouse (Comue de Toulouse)-Institut National des Sciences Appliquées (INSA)-Communauté d'universités et établissements de Toulouse (Comue de Toulouse)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE); University of New Brunswick (UNB) |
| Source: |
ISSN: 2050-6201 ; Evolution, Medicine, and Public Health ; https://hal.science/hal-04720811 ; Evolution, Medicine, and Public Health, 2024, 12 (1), pp.172-177. ⟨10.1093/emph/eoae021⟩. |
| Publisher Information: |
CCSD; Oxford : Oxford University Press |
| Publication Year: |
2024 |
| Collection: |
Université de Montpellier: HAL |
| Subject Terms: |
perspective; tumors; progression; evolution; selection; function; group phenotypic composition; [SDV.CAN]Life Sciences [q-bio]/Cancer |
| Description: |
International audience ; Tumorigenesis is commonly attributed to Darwinian processes involving natural selection among cells and groups of cells. However, progressing tumors are those that also achieve an appropriate group phenotypic composition (GPC). Yet, the selective processes acting on tumor GPCs are distinct from that associated with classical Darwinian evolution (i.e. natural selection based on differential reproductive success) as tumors are not genuine evolutionary individuals and do not exhibit heritable variation in fitness. This complex evolutionary scenario is analogous to the recently proposed concept of ‘selection for function’ invoked for the evolution of both living and non-living systems. Therefore, we argue that it is inaccurate to assert that Darwinian processes alone account for all the aspects characterizing tumorigenesis and cancer progression; rather, by producing the genetic and phenotypic diversity required for creating novel GPCs, these processes fuel the evolutionary success of tumors that is dependent on selection for function at the tumor level. |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| Relation: |
WOS: 001327551600001 |
| DOI: |
10.1093/emph/eoae021 |
| Availability: |
https://hal.science/hal-04720811; https://hal.science/hal-04720811v1/document; https://hal.science/hal-04720811v1/file/2024,%20Thomas%20et%20al,%20A%20new%20perspective%20on%20tumor%20progression,%20Evolution%20via%20selection%20for%20function.pdf; https://doi.org/10.1093/emph/eoae021 |
| Rights: |
https://creativecommons.org/licenses/by/4.0/ ; info:eu-repo/semantics/OpenAccess |
| Accession Number: |
edsbas.AC925318 |
| Database: |
BASE |