| Title: |
Circulating Memory is sufficient for protective immunity to secondary infection with Chlamydia |
| Authors: |
Labuda, Jasmine C; McSorley, Stephen J |
| Source: |
The Journal of Immunology ; volume 202, issue 1_Supplement, page 190.13-190.13 ; ISSN 0022-1767 1550-6606 |
| Publisher Information: |
Oxford University Press (OUP) |
| Publication Year: |
2019 |
| Description: |
Chlamydia trachomatis is the most prevalent bacterial STI worldwide and yet no vaccine currently exists to protect the public from this reproductive tract pathogen. Recent reports suggest that Tissue Resident Memory (TRM) T cells are essential for vaccine-induced protection against Chlamydia trachomatis in a mouse infection model. TRM T cells have also been implicated in protective immunity to other reproductive tract pathogens, including Herpes Simplex Virus. Here, we examine a requirement for circulating versus resident memory in protection against secondary infection with Chlamydia muridarum (Cm). When FTY720 was used to block memory lymphocyte circulation, protection against secondary infection was unaltered, demonstrating that local resident mechanisms within the female reproductive tract are sufficient for secondary protection. However, parabiosis surgery of memory and naïve mice demonstrated that naïve mice receiving circulating memory were also fully protected from Cm challenge, indicating that TRM are dispensable for protection. Ongoing experiments are examining the protective capacity of both TRM T cells and circulating memory and whether memory lymphocyte cluster (MLC) formation within the reproductive tract is an essential component of naturally acquired or transferred protective memory. Understanding the differential contribution of resident versus circulating memory to protective responses is vital for the development of new vaccines against Chlamydia infection. |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| DOI: |
10.4049/jimmunol.202.supp.190.13 |
| Availability: |
https://doi.org/10.4049/jimmunol.202.supp.190.13; https://academic.oup.com/jimmunol/article/202/1_Supplement/190.13/7957979 |
| Rights: |
https://academic.oup.com/pages/standard-publication-reuse-rights |
| Accession Number: |
edsbas.ACA55A3F |
| Database: |
BASE |