| Title: |
Pineal gland senescence: an emerging ageing-related pathology? |
| Authors: |
Short, Emma; Ajjan, Ramzi; Barber, Thomas M; Bhandari, Sunil; Chazot, Paul; Garrison, Jennifer; Huckstepp, Robert; Kanamarlapudi, Venkateswarlu; Lazar, Alpar; Tavares, Adriana; Tree, Jeremy J; Wellington, Jack; Calimport, Stuart RG; Bentley, Barry L; International Consortium for the Classification of Ageing-Related Pathologies (ICCARP) |
| Publisher Information: |
Zenodo |
| Publication Year: |
2024 |
| Collection: |
Zenodo |
| Description: |
An ageing-related pathology has recently been described as one that develops and/or progresses with increasing chronological age, that is associated with, or contributes to, functional decline, and is evidenced by studies in humans. The pineal gland is a photo-neuroendocrine organ whose primary function is to produce and secrete melatonin in response to environmental cues about the light-dark cycle. It undergoes ageing-related structural and morphological changes including calcification, gliosis, cyst formation, and a reduced density of β-adrenergic receptors, which are hypothesised to reduce melatonin secretion. Pineal gland senescence describes the ageing-related decline in neuroendocrine function, with reduced secretion of melatonin, which contributes to ageing-related sleep disorders, disruption of other circadian-driven physiological functions and may have secondary effects such as contributing to cognitive and mood disorders related to sleep disturbance.Funding:The project is funded by an Impetus grant from the Norn group. |
| Document Type: |
report |
| Language: |
unknown |
| Relation: |
https://zenodo.org/records/13868748; oai:zenodo.org:13868748; https://doi.org/10.5281/zenodo.13868748 |
| DOI: |
10.5281/zenodo.13868748 |
| Availability: |
https://doi.org/10.5281/zenodo.13868748; https://zenodo.org/records/13868748 |
| Accession Number: |
edsbas.AD6B9158 |
| Database: |
BASE |