| Title: |
Prognostic and Predictive Biomarkers in Patients with Locally Advanced Rectal Cancer (LARC) Treated with Preoperative Chemoradiotherapy |
| Authors: |
Alfonso Martín-Carnicero; Enrique Ramalle-Gomara; Susana Rubio-Mediavilla; Martina Alonso-Lago; Miriam Zorrilla-Larraga; Isabel Manrique-Abós; María E. de las Heras-Dueña; Ignacio M. Larrayoz; Alfredo Martínez |
| Source: |
Journal of Clinical Medicine, Vol 11, Iss 6091, p 6091 (2022) |
| Publisher Information: |
MDPI AG |
| Publication Year: |
2022 |
| Collection: |
Directory of Open Access Journals: DOAJ Articles |
| Subject Terms: |
locally advanced rectal cancer; neoadjuvant chemoradiotherapy; prognostic biomarkers; predictive biomarkers; hemoglobin; lymphocyte/monocyte ratio; Medicine |
| Description: |
Neoadjuvant chemoradiotherapy (CRT) is one of the standards of care in locally advanced rectal cancer (LARC). This retrospective study examines clinical, analytical, and pathological parameters collected from 77 patients with locally advanced (cT3-4 or cN+) rectal carcinoma diagnosed between 2007 and 2017 at our institution that were treated with preoperative CRT and surgery. In the prognosis analysis, lower hemoglobin levels ( p = 0.008), lower lymphocyte/monocyte ratio (LMR) ( p = 0.011), and higher platelet/lymphocyte ratio (PLR) ( p = 0.029) in the second determination (Hb2, LMR2 and PLR2) were associated with the relapse group. The number of positive nodes after surgery (N+) showed a statistically significant association with relapse ( p = 0.012). KRAS mutations were associated with a worse prognosis for 5 years progression-free and overall survival ( p = 0.005 and 0.022; respectively). We propose a prognostic model based on four parameters (number of positive lymph nodes after surgery, hemoglobin levels, LMR, and PLR after neoadjuvant therapy) that can be a useful tool to estimate relapse risk. Moreover, bilirubin could be a useful parameter to predict the response to neoadjuvant CRT. |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| Relation: |
https://www.mdpi.com/2077-0383/11/20/6091; https://doaj.org/toc/2077-0383; https://doaj.org/article/6f9f05fe0dec4b6184864edb305c71d6 |
| DOI: |
10.3390/jcm11206091 |
| Availability: |
https://doi.org/10.3390/jcm11206091; https://doaj.org/article/6f9f05fe0dec4b6184864edb305c71d6 |
| Accession Number: |
edsbas.ADE0491C |
| Database: |
BASE |