TLCD1 and TLCD2 regulate cellular phosphatidylethanolamine composition and promote the progression of non-alcoholic steatohepatitis
| Title: | TLCD1 and TLCD2 regulate cellular phosphatidylethanolamine composition and promote the progression of non-alcoholic steatohepatitis |
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| Authors: | Kasparas Petkevicius; Henrik Palmgren; Matthew S. Glover; Andrea Ahnmark; Anne-Christine Andréasson; Katja Madeyski-Bengtson; Hiroki Kawana; Erik L. Allman; Delaney Kaper; Martin Uhrbom; Liselotte Andersson; Leif Aasehaug; Johan Forsström; Simonetta Wallin; Ingela Ahlstedt; Renata Leke; Daniel Karlsson; Hernán González-King; Lars Löfgren; Ralf Nilsson; Giovanni Pellegrini; Nozomu Kono; Junken Aoki; Sonja Hess; Grzegorz Sienski; Marc Pilon; Mohammad Bohlooly-Y; Marcello Maresca; Xiao-Rong Peng |
| Source: | Nature Communications, Vol 13, Iss 1, Pp 1-14 (2022) |
| Publisher Information: | Nature Portfolio |
| Publication Year: | 2022 |
| Collection: | Directory of Open Access Journals: DOAJ Articles |
| Subject Terms: | Science |
| Description: | The regulation of cellular phosphatidylethanolamine (PE) acyl chain composition is poorly understood. Here, the authors show that TLCD1 and TLCD2 proteins mediate the formation of monounsaturated fatty acid-containing PE species and promote the progression of non-alcoholic steatohepatitis. |
| Document Type: | article in journal/newspaper |
| Language: | English |
| Relation: | https://doi.org/10.1038/s41467-022-33735-6; https://doaj.org/toc/2041-1723; https://doaj.org/article/15464563b39b4d54986a8c040d9d92b8 |
| DOI: | 10.1038/s41467-022-33735-6 |
| Availability: | https://doi.org/10.1038/s41467-022-33735-6; https://doaj.org/article/15464563b39b4d54986a8c040d9d92b8 |
| Accession Number: | edsbas.ADEA766A |
| Database: | BASE |