| Title: |
Plasma lipid profiles discriminate bacterial from viral infection in febrile children |
| Authors: |
Wang, Xinzhu; Nijman, Ruud Gerard; Camuzeaux, Stephane; Sands, Caroline; Jackson, Heather R.; Kaforou, Myrsini; Emonts, Marieke; Herberg, Jethro A.; Maconochie, Ian; Carrol, Enitan; Paulus, Stéphane; Zenz, Werner; van der Flier, Michiel; de Groot, Ronald C.A.; Martinon-Torres, Federico; Schlapbach, Luregn; Pollard, AJ.; Fink, Colin; Kuijpers, T. W.; Anderson, Suzanne T. B.; Lewis, Matthew R.; Levin, Michael; McClure, Myra; Gormley, Stuart; Hamilton, Shea; Hourmat, Bernardo; Hoggart, Clive; Sancho Shimizu, Vanessa; Wright, Victoria; Abdulla, Amina F.; Agapow, Paul Michael; Bartlett, Maeve; Bellos, Evangelos; Eleftherohorinou, Hariklia; Galassini, Rachel; Inwald, David; Mashbat, Meg; Menikou, Stephanie; Mustafa, Sobia; Nadel, Simon; Rahman, Rahmeen; Thakker, Clare; Coin, Lachlan; Bokhandi, Sumit S.; Power, Sue; Barham, Heather; Pathan, Nazima; Ridout, Jenna; White, Deborah; Thurston, Sarah; Faust, Saul; Patel, Sanjay Valabh; McCorkell, Jenni; Davies, Patrick; Crate, Lindsay; Navarra, Helen; Carter, Stephanie; Ramaiah, Raghu; Patel, Rekha; Tuffrey, Catherine; Gribbin, Andrew; McCready, Sharon; Peters, Mark; Hardy, Katie; Standing, Fran; O'Neill, Lauren; Abelake, Eugenia; Deep, Akash; Nsirim, Eniola; Willis, Louise; Young, Zoe; Royad, C.; White, Sonia; Fortune, Peter-Marc; Hudnott, Phil; Álvez González, Fernando; Barral-Arca, Ruth; Cebey-López, Miriam; Curras-Tuala, MJ.; García, Natalia; Vicente, Luisa García; Gómez-Carballa, Alberto; Gomez-Rial, Jose; Grela Beiroa, Andrea; Justicia-Grande, Antonio; Iglesias, Pilar Leboráns; Martinez-Santos, Alba-Elena; MartinónTorres, Nazareth; Sánchez, José María; Morillo Gutiérrez, Beatriz; Pérez, Belén Mosquera; Pacheco, Pablo Obando; Pardo-Seco, Jacobo; Pischedda, Sara; Rivero Calle, Irene; Rodríguez-Tenreiro, Carmen; Redondo Collazo, Lorenzo; Ellacuriagal, Antonio Salas; Serén Fernández, Sonia; Silva, María Del Sol Porto; Vega, Ana Karina; Vilanova-Trillo, Lucía; Salas, Antonio; Reyes, Susana Beatriz; León-León, María Cruz; Mingorance, Álvaro Navarro; Barrios, Xavier Gabaldó; Oñate Vergara, Eider; Concha-Torre, Andres; Vivanco, Ana; Fernández, Reyes; Giménez-Sánchez, Francisco; Sánchez Forte, Miguel; Rojo, Pablo; Contreras, J. Ruiz; Palacios, Alba; Ibarrondo, Cristina Epalza; Cooke, Elizabeth Fernández; Navarro, Marisa; Álvarez, Cristina Álvarez; Lozano, María José; Carreras, Eduardo; Brió Sanagustín, Sonia; Neth, Olaf; Padilla, Ma del Carmen Martínez; Tato, Luis Manuel Prieto; Guillén, Sara; Fernandez Silveira, Laura; Moreno Pérez, David; van Furth, Marceline; Boeddha, Navin P.; Driessen, Gertjan Jan A.; Hazelzet, Jan; Pajkrt, Dasja; Sanders, Elisabeth A. M.; van de Beek, Diederik; van der Ende, Arie; Philipsen, H.L.A.; Adeel, Abdul O.A.; Breukels, Meike A.; Brinkman, Daniëlle M.C.; Korte, Carla C.M.M. de; de Vries, Esther; de Waal, Wouter J.; Dekkers, Roel; Dings-Lammertink, Anouk; Doedens, Rienus A.; Donker, AlbertineE.; Dousma, Mieke; Faber, Tina E.; Gerrits, Gerardus Peter Jm M.; Gerver, Jan A.M.; Heidema, Jojanneke; Veen, J. Homan-van der; Jacobs, Monique A.M.; Jansen, Nicolaas Johannes Georgius; Kawczynski, Pawel; Klucovska, Kristine; Kneyber, Martin Christiaan Jacques; Koopman-Keemink, Yvonne; Langenhorst, Veerle J.; Leusink, José; Loza, Bettina F.; Merth, Istvan T.; Miedema, Carien J.; Neeleman, Chris; Noordzij, Jeroen G.; Obihara, Charlie C.C.; van Overbeek - van Gils, A. Lidy T.; Poortman, Geriska H.; Potgieter, Steph T.; Potjewijd, Joke; Rosias, Philippe P.R.; Sprong, Tom; ten Tussher, Gavin W.; Thio, Bernard J.; Tramper-Stranders, Gerdien A.; van Deuren, M.; van der Meer, H.; van Kuppevelt, A.J.M.; van Wermeskerken, A.M.; Verwijs, W.A.; Wolfs, T.F.W.; Agyeman, Philipp; Aebi, Christoph; Berger, Christoph; Giannoni, E.; Stocker, M.; Posfay-Barbe, K.M.; Heininger, U.; Bernhard-Stirnemann, Sara; Niederer-Loher, A.; Kahlert, C.; Hasters, P.; Relly, C.; Baer, Walter; Frederick, H.; Jennings, Rebecca; Johnston, J.; Kenwright, R.; Pinnock, Ellie; Agbeko, Rachel; Secka, Fatou; Bojang, Kalifa; Sarr, Isatou; Kebbeh, Ngange; Sey, Gibbi; Momodou, None; khan, Saidy; Cole, Fatoumata; Thomas, Gilleh; Antonio, Martin; Klobassa, Daniela S.; Binder, Alexander; Schweintzger, Nina; Sagmeister, Manfred; Baumgart, Hinrich; Baumgartner, Markus; Behrends, Uta; Biebl, Ariane; Birnbacher, Robert; Blanke, Jan-Gerd; Boelke, Carsten; Breuling, Kai; Brunner, Jürgen; Buller, Maria; Dahlem, Peter; Dietrich, Beate; Eber, Ernst; Elias, Johannes; Emhofer, Josef; Etschmaier, Rosa; Farr, Sebastian; Girtler, Ylenia; Grigorow, Irina; Heimann, Konrad; Ihm, Ulrike; Jaros, Zdenek; Kalhoff, Hermann; Kaulfersch, Wilhelm; Kemen, Christoph; Klocker, Nina; Köster, Bernhard; Kohlmaier, B.; Komini, Eleni; Kramer, Lydia; Neubert, Antje; Ortner, Daniel; Pescollderungg, Lydia; Pfurtscheller, Klaus; Reiter, Karl; Ristic, Goran; Rödl, Siegfried; Sellner, Andrea; Sonnleitner, Astrid; Sperl, Matthias; Stelzl, Wolfgang; Till, Holger Karl H.; Trobisch, Andreas; Vierzig, Anne; Vogel, Ulrich; Weingarten, Christina; Welke, Stefanie; Wimmer, Andreas; Wintergerst, Uwe; Wüller, Daniel; Zaunschirm, Andrew; Ziuraite, Ieva; Žukovskaja, Veslava; Universitat Autònoma de Barcelona |
| Publication Year: |
2019 |
| Collection: |
Universitat Autònoma de Barcelona: Dipòsit Digital de Documents de la UAB |
| Subject Terms: |
Diagnostic markers; Metabolomics |
| Description: |
Fever is the most common reason that children present to Emergency Departments. Clinical signs and symptoms suggestive of bacterial infection are often non-specific, and there is no definitive test for the accurate diagnosis of infection. The 'omics' approaches to identifying biomarkers from the host-response to bacterial infection are promising. In this study, lipidomic analysis was carried out with plasma samples obtained from febrile children with confirmed bacterial infection (n = 20) and confirmed viral infection (n = 20). We show for the first time that bacterial and viral infection produces distinct profile in the host lipidome. Some species of glycerophosphoinositol, sphingomyelin, lysophosphatidylcholine and cholesterol sulfate were higher in the confirmed virus infected group, while some species of fatty acids, glycerophosphocholine, glycerophosphoserine, lactosylceramide and bilirubin were lower in the confirmed virus infected group when compared with confirmed bacterial infected group. A combination of three lipids achieved an area under the receiver operating characteristic (ROC) curve of 0.911 (95% CI 0.81 to 0.98). This pilot study demonstrates the potential of metabolic biomarkers to assist clinicians in distinguishing bacterial from viral infection in febrile children, to facilitate effective clinical management and to the limit inappropriate use of antibiotics. |
| Document Type: |
article in journal/newspaper |
| File Description: |
application/pdf |
| Language: |
English |
| ISSN: |
20452322 |
| Relation: |
Scientific reports; Vol. 9 Núm. 1 (january 2019), p. 17714; https://ddd.uab.cat/record/286550; urn:oai:ddd.uab.cat:286550; urn:scopus_id:85075710136; urn:articleid:20452322v9n1a17714; urn:pmid:31776453; urn:pmcid:PMC6881435; urn:oai:pubmedcentral.nih.gov:6881435 |
| Availability: |
https://ddd.uab.cat/record/286550 |
| Rights: |
open access ; Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original. ; https://creativecommons.org/licenses/by/4.0/ |
| Accession Number: |
edsbas.AE13FB4A |
| Database: |
BASE |