| Title: |
Long-Term Impact of COVID-19 on Disorders of Gut-Brain Interaction: Incidence, Symptom Burden, and Psychological Comorbidities |
| Authors: |
Marasco G; Hod K; Colecchia L; Cremon C; Barbaro MR; Cacciari G; Falangone F; Kagramanova A; Bordin D; Drug V; Miftode E; Fusaroli P; Mohamed SY; Ricci C; Bellini M; Rahman MM; Melcarne L; Santos J; Lobo B; Bor S; Yapali S; Akyol D; Sapmaz FP; Urun YY; Eskazan T; Celebi A; Kacmaz H; Ebik B; Binicier HC; Bugdayci MS; Yağcı MB; Pullukcu H; Kaya BY; Tureyen A; Hatemi İ; Koc ES; Sirin G; Calıskan AR; Bengi G; Alıs EE; Lukic S; Trajkovska M; Dumitrascu D; Pietrangelo A; Corradini E; Simren M; Sjolund J; Tornkvist N; Ghoshal UC; Kolokolnikova O; Colecchia A; Serra J; Maconi G; De Giorgio R; Danese S; Portincasa P; Di Sabatino A; Maggio M; Philippou E; Lee YY; Salvi D; Venturi A; Borghi C; Zoli M; Gionchetti P; Viale P; Stanghellini V; Barbara G; GI‐COVID19 study groups |
| Contributors: |
Marasco G; Hod K; Colecchia L; Cremon C; Barbaro Mr; Cacciari G; Falangone F; Kagramanova A; Bordin D; Drug V; Miftode E; Fusaroli P; Mohamed Sy; Ricci C; Bellini M; Rahman Mm; Melcarne L; Santos J; Lobo B; Bor S; Yapali S; Akyol D; Sapmaz Fp; Urun Yy; Eskazan T; Celebi A; Kacmaz H; Ebik B; Binicier Hc; Bugdayci M; Yağcı, Mb; Pullukcu H; Kaya By; Tureyen A; Hatemi İ; Koc E; Sirin G; Calıskan Ar; Bengi G; Alıs Ee; Lukic S; Trajkovska M; Dumitrascu D; Pietrangelo A; Corradini E; Simren M; Sjolund J; Tornkvist N; Ghoshal Uc; Kolokolnikova O; Colecchia A; Serra J; Maconi G; De Giorgio R; Danese S; Portincasa P; Di Sabatino A; Maggio M; Philippou E; Lee Yy; Salvi D; Venturi A; Borghi C; Zoli M; Gionchetti P; Viale P; Stanghellini V; Barbara G; GI‐COVID19 study Groups |
| Publication Year: |
2025 |
| Collection: |
Università degli Studi di Brescia: OPENBS - Open Archive UniBS |
| Subject Terms: |
anxiety | COVID‐19 | depression | disorders of gut‐brain interaction | functional dyspepsia | gastrointestinal symptoms | irritable bowel syndrome | post‐infection gastrointestinal disorders syndrome | post‐infection gastrointestinal disorders |
| Description: |
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic has highlighted the potential exacerbation of gastrointestinal symptoms in patients with disorders of gut-brain interaction (DGBIs). However, the distinct symptom trajectories and psychological burden in patients with post-COVID-19 DGBIs compared with patients with pre-existing irritable bowel syndrome (IBS)/functional dyspepsia (FD) and non-DGBI controls remain poorly understood. Objectives: To examine the long-term gastrointestinal symptom progression and psychological comorbidities in patients with post-COVID-19 DGBI, patients with pre-existing IBS/FD and non-DGBI controls. Methods: This post hoc analysis of a prospective multicenter cohort study reviewed patient charts for demographic data and medical history. Participants completed the Gastrointestinal Symptom Rating Scale at four time points: baseline, 1, 6, and 12 months, and the Hospital Anxiety and Depression Scale at 6 and 12 months. The cohort was divided into three groups: (1) post-COVID-19 DGBIs (2) non-DGBI, and (3) pre-existing IBS/FD, with the post-COVID-19 DGBIs group compared to the latter two control groups. Results: Among 599 eligible patients, 27 (4.5%) were identified as post-COVID-19 DGBI. This group experienced worsening abdominal pain, hunger pain, heartburn, and acid regurgitation, unlike symptom improvement or stability in non-DGBI controls (p < 0.001 for all symptoms, except hunger pain, p = 0.001). While patients with pre-existing IBS/FD improved in most gastrointestinal symptoms but worsened in constipation and incomplete evacuation, patients with post-COVID-19 DGBI exhibited consistent symptom deterioration across multiple gastrointestinal domains. Anxiety and depression remained unchanged in patients with post-COVID-19 DGBI, contrasting with significant reductions in controls (non-DGBI: p = 0.003 and p = 0.057; pre-existing IBS/FD: p = 0.019 and p = 0.007, respectively). Conclusions: COVID-19 infection is associated with the development of newly diagnosed ... |
| Document Type: |
article in journal/newspaper |
| File Description: |
ELETTRONICO |
| Language: |
English |
| Relation: |
info:eu-repo/semantics/altIdentifier/pmid/40119532; info:eu-repo/semantics/altIdentifier/wos/WOS:001469417300001; volume:1; firstpage:1; lastpage:21; numberofpages:21; journal:UNITED EUROPEAN GASTROENTEROLOGY JOURNAL; https://hdl.handle.net/11379/626725 |
| DOI: |
10.1002/ueg2.70005 |
| Availability: |
https://hdl.handle.net/11379/626725; https://doi.org/10.1002/ueg2.70005 |
| Rights: |
info:eu-repo/semantics/openAccess |
| Accession Number: |
edsbas.AE216F08 |
| Database: |
BASE |