| Title: |
Analysis of saccadic eye movements in the prodromal phase of Alzheimer's disease ; Analyse des mouvements oculaires saccadiques à la phase prodromale de la maladie d’Alzheimer |
| Authors: |
Cosnard, Alexandre |
| Contributors: |
Université de Bordeaux (UB); François Tison |
| Source: |
https://dumas.ccsd.cnrs.fr/dumas-01598098 ; Médecine humaine et pathologie. 2017. |
| Publisher Information: |
CCSD |
| Publication Year: |
2017 |
| Collection: |
DUMAS (Dépôt Universitaire de Mémoires Après Soutenance) |
| Subject Terms: |
Saccade; Anti-saccade; Mouvement oculaire; Maladie d’Alzheimer prodromale; Maladie d'Alzheimer; [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology |
| Description: |
Objective. The aim of our study was to examine saccadic eye movements through several paradigms in patients with prodromal Alzheimer's disease (PAD) compared with patients suffering from mild to moderate Alzheimer's disease (AD) and aged-matched controls. Methods. We recorded eye movements by automated infrared eye-tracking in 79 patients (PAD: 29, AD: 23, controls: 27). The reflex saccades (horizontal gap and vertical step paradigms) and voluntary (antisaccades (AS), spatial decision and prediction paradigms) were studied. All subjects also received a neuropsychological test battery. We studied the correlations between the AS error rate and the neuropsychological scale scores. Results. PAD patients showed more AS directional errors compared to the control group (46.9%, standard deviation 25.9% versus 24.3%, standard deviation 19.8%, p = 0.0007). AS initiation latency was higher in PAD patients than in AD patients (p = 0.0335). Execution parameters of the saccades (precision, velocity, latency) were globally not altered. AS errors percentage was correlated with most of neuropsychological tests, including the Mini-Mental State Examination. In general, correlations were weak to moderate. Conclusion. It seems that there exists a "pattern" of saccadic execution detectable by automated analysis at an early stage of AD. Quick and easy, saccades exploration may constitute a new diagnosis biomarker of prodromal AD. ; Objectif. Le but de notre étude était d’examiner les mouvements oculaires saccadiques à travers plusieurs paradigmes chez des patients présentant une maladie d'Alzheimer prodromale (MAP) comparativement à des patients souffrant d'une maladie d'Alzheimer (MA) au stade léger à modéré et des sujets sains contrôles appariés pour l'âge. Matériels et méthodes. Nous avons enregistré les saccades par oculométrie infra-rouge automatisée chez 79 patients (MAP: 29; MA: 23; contrôles: 27). Les paramètres d'exécution des saccades réflexes (paradigmes gap horizontal et step vertical) et volontaires (paradigmes des ... |
| Document Type: |
master thesis |
| Language: |
French |
| Availability: |
https://dumas.ccsd.cnrs.fr/dumas-01598098; https://dumas.ccsd.cnrs.fr/dumas-01598098v1/document; https://dumas.ccsd.cnrs.fr/dumas-01598098v1/file/Med_spe_2017_Cosnard.pdf |
| Rights: |
https://about.hal.science/hal-authorisation-v1/ ; info:eu-repo/semantics/OpenAccess |
| Accession Number: |
edsbas.AE33AF67 |
| Database: |
BASE |