| Title: |
Reference Intervals for Brachial Artery Flow-Mediated Dilation and the Relation with Cardiovascular Risk Factors |
| Authors: |
Holder, SM; Bruno, RM; Shkredova, DA; Dawson, EA; Jones, H; Hopkins, ND; Hopman, MTE; Bailey, TG; Coombes, JS; Askew, CD; Naylor, L; Maiorana, A; Ghiadoni, L; Thompson, A; Green, DJ; Thijssen, DHJ |
| Publisher Information: |
Ovid Technologies (Wolters Kluwer Health) |
| Publication Year: |
2021 |
| Collection: |
The University of Liverpool Repository |
| Description: |
Endothelial function, assessed using brachial artery flow-mediated dilation (FMD), predicts future cardiovascular disease (CVD) risk. This study established age- and sex-specific reference intervals for brachial artery FMD in healthy individuals and examined the relation with CVD risk factors. In a retrospective study design, we pooled brachial artery FMD (acquired according to expert-consensus guidelines for FMD protocol and analysis) and participant characteristics/medical history from 5362 individuals (4-84 years; 2076 females). Healthy individuals (n=1403 [582 females]) were used to generate age-/sex-specific percentile curves. Subsequently, we included individuals with CVD risk factors, without overt disease (unmedicated n=3167 [1247 females] and medicated n=792 [247 females]). Multiple linear regression tested the relation of CVD risk factors (body mass index, blood pressure, cholesterol, diabetes, dyslipidemia, and smoking) with FMD. Healthy males showed a negative, curvilinear relation between FMD and age, while females revealed a negative linear relation that started higher but declined at a faster rate than males. Age- and sex-specific differences in FMD relate, at least partly, to baseline artery diameter. FMD was related to CVD risk factors in unmedicated (eg, systolic/diastolic blood pressure) and medicated individuals (eg, diabetes/dyslipidemia). Sex mediated some of these effects (P |
| Document Type: |
article in journal/newspaper |
| File Description: |
text |
| Language: |
English |
| ISSN: |
0194-911X |
| Relation: |
https://livrepository.liverpool.ac.uk/3124363/1/Holder_HYPE-2020-15754.submission_version.docx; Collapse authors list. Holder, SM, Bruno, RM, Shkredova, DA, Dawson, EA, Jones, H, Hopkins, ND, Hopman, MTE, Bailey, TG, Coombes, JS, Askew, CD et al (show 6 more authors) , Naylor, L, Maiorana, A, Ghiadoni, L, Thompson, A orcid:0000-0002-7087-9415 , Green, DJ and Thijssen, DHJ (2021) Reference Intervals for Brachial Artery Flow-Mediated Dilation and the Relation with Cardiovascular Risk Factors Hypertension, 77 (5). pp. 1469-1480. ISSN 0194-911X, 1524-4563 |
| DOI: |
10.1161/hypertensionaha.120.15754 |
| Availability: |
https://livrepository.liverpool.ac.uk/3124363/; https://doi.org/10.1161/hypertensionaha.120.15754 |
| Accession Number: |
edsbas.AE53EF8C |
| Database: |
BASE |