| Title: |
Long-term Survival in Breast Cancer Patients Is Associated with Contralateral Parenchymal Enhancement at MRI: Outcomes of the SELECT Study |
| Authors: |
Ragusi, Max A.A.; van der Velden, Bas H.M.; Meeuwis, Carla; Tetteroo, Eric; Coerkamp, Emile G.; van Nijnatten, Thiemo J.A.; Jansen, Frits H.; Wolters- van der Ben, Elian J.M.; Jongen, Lisa; van Raamt, Fleur; Dorrius, Monique D.; Verloop, Janneke; Viergever, Max A.; Pijnappel, Ruud M.; Elias, Sjoerd G.; Gilhuijs, Kenneth G.A. |
| Source: |
Radiology 307 (2023) 4 ; ISSN: 0033-8419 |
| Publication Year: |
2023 |
| Collection: |
Wageningen UR (University & Research Centre): Digital Library |
| Subject Terms: |
Life Science |
| Description: |
BackgroundSeveral single-center studies found that high contralateral parenchymal enhancement (CPE) at breast MRI was associated with improved long-term survival in patients with estrogen receptor (ER)–positive and human epidermal growth factor receptor 2 (HER2)–negative breast cancer. Due to varying sample sizes, population characteristics, and follow-up times, consensus of the association is currently lacking.PurposeTo confirm whether CPE is associated with long-term survival in a large multicenter retrospective cohort, and to investigate if CPE is associated with endocrine therapy effectiveness.Materials and MethodsThis multicenter observational cohort included women with unilateral ER-positive HER2-negative breast cancer (tumor size ≤50 mm and ≤three positive lymph nodes) who underwent MRI from January 2005 to December 2010. Overall survival (OS), recurrence-free survival (RFS), and distant RFS (DRFS) were assessed. Kaplan-Meier analysis was performed to investigate differences in absolute risk after 10 years, stratified according to CPE tertile. Multivariable Cox proportional hazards regression analysis was performed to investigate whether CPE was associated with prognosis and endocrine therapy effectiveness.ResultsOverall, 1432 women (median age, 54 years [IQR, 47–63 years]) were included from 10 centers. Differences in absolute OS after 10 years were stratified according to CPE tertile as follows: 88.5% (95% CI: 88.1, 89.1) in tertile 1, 85.8% (95% CI: 85.2, 86.3) in tertile 2, and 85.9% (95% CI: 85.4, 86.4) in tertile 3. CPE was independently associated with OS, with a hazard ratio (HR) of 1.17 (95% CI: 1.0, 1.36; P = .047), but was not associated with RFS (HR, 1.11; P = .16) or DRFS (HR, 1.11; P = .19). The effect of endocrine therapy on survival could not be accurately assessed; therefore, the association between endocrine therapy efficacy and CPE could not reliably be estimated.ConclusionHigh contralateral parenchymal enhancement was associated with a marginally decreased overall survival in patients ... |
| Document Type: |
article in journal/newspaper |
| File Description: |
text/html |
| Language: |
English |
| Relation: |
https://edepot.wur.nl/629899 |
| DOI: |
10.1148/radiol.221922 |
| Availability: |
https://research.wur.nl/en/publications/long-term-survival-in-breast-cancer-patients-is-associated-with-c; https://doi.org/10.1148/radiol.221922 |
| Rights: |
https://creativecommons.org/licenses/by/4.0/ ; Wageningen University & Research |
| Accession Number: |
edsbas.AE7EB4F2 |
| Database: |
BASE |