| Title: |
Integrative multi-omics analyses to identify the genetic and functional mechanisms underlying ovarian cancer risk regions |
| Authors: |
Dareng,Eileen O.; Coetzee,Simon G.; Tyrer,Jonathan P.; Peng,Pei Chen; Rosenow,Will; Chen,Stephanie; Davis,Brian D.; Dezem,Felipe Segato; Seo,Ji Heui; Nameki,Robbin; Reyes,Alberto L.; Aben,Katja K.H.; Anton-Culver,Hoda; Antonenkova,Natalia N.; Aravantinos,Gerasimos; Bandera,Elisa V.; Beane Freeman,Laura E.; Beckmann,Matthias W.; Beeghly-Fadiel,Alicia; Benitez,Javier; Bernardini,Marcus Q.; Bjorge,Line; Black,Amanda; Bogdanova,Natalia V.; Bolton,Kelly L.; Brenton,James D.; Budzilowska,Agnieszka; Butzow,Ralf; Cai,Hui; Campbell,Ian; Cannioto,Rikki; Chang-Claude,Jenny; Chanock,Stephen J.; Chen,Kexin; Chenevix-Trench,Georgia; Chiew,Yoke Eng; Cook,Linda S.; DeFazio,Anna; Dennis,Joe; Doherty,Jennifer A.; Dörk,Thilo; du Bois,Andreas; Dürst,Matthias; Eccles,Diana M.; Ene,Gabrielle; Fasching,Peter A.; Flanagan,James M.; Fortner,Renée T.; Fostira,Florentia; Onland-Moret, N. Charlotte; AOCS Group; OPAL Study Group; The Ovarian Cancer Association Consortium (OCAC); Data gedreven innovatie; JC onderzoeksprogramma Cardiovascular Health; Circulatory Health; Cardiovasculaire Epi Team 3 |
| Publication Year: |
2024 |
| Subject Terms: |
epithelial ovarian cancer risk; fine mapping; functional mechanisms; GWAS; Taverne; Genetics; Genetics(clinical) |
| Description: |
To identify credible causal risk variants (CCVs) associated with different histotypes of epithelial ovarian cancer (EOC), we performed genome-wide association analysis for 470,825 genotyped and 10,163,797 imputed SNPs in 25,981 EOC cases and 105,724 controls of European origin. We identified five histotype-specific EOC risk regions (p value |
| Document Type: |
article in journal/newspaper |
| File Description: |
text/plain |
| Language: |
English |
| ISSN: |
0002-9297 |
| Relation: |
https://dspace.library.uu.nl/handle/1874/455348 |
| Availability: |
https://dspace.library.uu.nl/handle/1874/455348 |
| Rights: |
info:eu-repo/semantics/OpenAccess |
| Accession Number: |
edsbas.AE86E04F |
| Database: |
BASE |