| Title: |
Microbiota-gut-brain axis dysregulation in Alzheimer’s disease and its modulation through probiotic supplementation |
| Authors: |
Marizzoni M.; Mombelli E.; Alboni S.; Rosa M.; Moretti D. V.; Mirabelli P.; Coppola L.; Luongo D.; Salamone D.; Saleri S.; Piazza F.; Begni V.; Salvatore M.; Frisoni G. B.; Cattaneo A. |
| Contributors: |
Marizzoni, M.; Mombelli, E.; Alboni, S.; Rosa, M.; Moretti, D. V.; Mirabelli, P.; Coppola, L.; Luongo, D.; Salamone, D.; Saleri, S.; Piazza, F.; Begni, V.; Salvatore, M.; Frisoni, G. B.; Cattaneo, A. |
| Publication Year: |
2026 |
| Collection: |
Archivio della ricerca dell'Università di Modena e Reggio Emilia (Unimore: IRIS) |
| Subject Terms: |
Alzheimer’s disease; Gut-microbiota-brain axi; Probiotic supplementation |
| Description: |
The microbiota-gut-brain axis (MGBA) has been implicated in the pathophysiology of Alzheimer’s Disease (AD).Probiotics reduced the progression of ADin different mouse models, possibly through MGBA modulation, but human data are still limited. Here, we evaluated whether differences in the gut microbiome (GM), pro-inflammatory markers and other MGBA mediators were associated with probable AD (pAD). We also assessed the impact of a 12-week probiotic treatment on MGBA. Forty-five pAD patients and 47 healthy subjects (HC) were recruited at IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli of Brescia (Italy). An uncontrolled clinical investigation was performed to test the effects of 12-week probiotic supplementation in the pAD group. Fecal microbiota composition, intestinal and blood inflammatory markers, and microbiota-related metabolites were assessed before supplementation in all participants and after only in pAD. pAD patients showed intestinal inflammation, an altered GM profile, blood changes in the tryptophan metabolism, and reduced glutamate levels compared with HC (p-value |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| Relation: |
info:eu-repo/semantics/altIdentifier/wos/WOS:001603077300003; volume:131; firstpage:1; lastpage:9; journal:BRAIN BEHAVIOR AND IMMUNITY; https://hdl.handle.net/11380/1392410 |
| DOI: |
10.1016/j.bbi.2025.106138 |
| Availability: |
https://hdl.handle.net/11380/1392410; https://doi.org/10.1016/j.bbi.2025.106138 |
| Rights: |
info:eu-repo/semantics/openAccess ; license:[IR] creative-commons ; license uri:http://creativecommons.org/licenses/by/4.0/ |
| Accession Number: |
edsbas.AEA0A2D1 |
| Database: |
BASE |