| Title: |
Abstract 12406: Mitral Valve Prolapse: Immune Response as a New Player |
| Authors: |
delwarde, constance; Aumond, Pascal; toquet, claire; Sizorn, Melissa; Lauzier, Benjamin; VEZIERS, Joëlle; Blandin, Stephanie; Kayvanjoo, Amir H; Mass, Elvira; Remy, Severine; Anegon, Ignacio; Schott, Jean-Jacques; Le Tourneau, Thierry; Merot, Jean; Capoulade, Romain |
| Source: |
Circulation ; volume 144, issue Suppl_1 ; ISSN 0009-7322 1524-4539 |
| Publisher Information: |
Ovid Technologies (Wolters Kluwer Health) |
| Publication Year: |
2021 |
| Description: |
Introduction: Mitral Valve Prolapse (MVP) is observed in 3% of the population. The pathophysiological mechanisms leading to MVP remain elusive and the only therapeutic option is to perform valve surgery. We previously identified FLNA as the first gene causing MVP and generated a unique knock-in (KI) rat model for the FLNA-P637Q mutation. Hypothesis: We assessed the hypothesis that MVP pathophysiology is multifactorial. Methods: 5 WT and 10 KI rats were morphologically, functionally and histologically evaluated at 3, 6 and 13 weeks based on 2D echocardiography, 3D micro computed tomography (μCT) and histology. Mitral valve (MV) RNA-sequencing was performed and metaclusters (MC) have been identified. Immunofluorescence and cytometry experiments on MV were used. Results: Echocardiographic and μCT imaging confirmed the presence of MV prolapse, elongated anterior leaflet (+12 to +14% for all time points p |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| DOI: |
10.1161/circ.144.suppl_1.12406 |
| Availability: |
https://doi.org/10.1161/circ.144.suppl_1.12406 |
| Accession Number: |
edsbas.AEE5DF1 |
| Database: |
BASE |