Acute respiratory distress syndrome after SARS-CoV-2 infection on young adult population: International observational federated study based on electronic health records through the 4CE consortium
| Title: | Acute respiratory distress syndrome after SARS-CoV-2 infection on young adult population: International observational federated study based on electronic health records through the 4CE consortium |
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| Authors: | Orieux A.; Ferte T.; Jouhet V.; Aaron J. R.; Agapito G.; Albayrak A.; Albi G.; Alessiani M.; Alloni A.; Amendola D. F.; Angoulvant F.; Anthony L. L. L. J.; Aronow B. J.; Ashraf F.; Atz A.; Avillach P.; Panickan V. A.; Azevedo P. S.; Balshi J.; Batugo A.; Beaulieu-Jones B. K.; Beau-Lieu-Jones B. R.; Bell D. S.; Bellasi A.; Bellazzi R.; Benoit V.; Beraghi M.; Bernal-Sobrino J. L.; Bernaux M.; Bey R.; Bhatnagar S.; Blanco-Martinez A.; Boeker M.; Bonzel C. -L.; Booth J.; Bosari S.; Bourgeois F. T.; Bradford R. L.; Brat G. A.; Breant S.; Brown N. W.; Bruno R.; Bryant W. A.; Bucalo M.; Bucholz E.; Burgun A.; Cai T.; Cannataro M.; Carmona A.; Cattelan A. M.; Caucheteux C.; Champ J.; Chen K. Y.; Chen J.; Chiovato L.; Chiudinelli L.; Cho K.; Cimino J. J.; Colicchio T. K.; Cormont S.; Cossin S.; Craig J. B.; Cruz-Bermudez J. L.; Cruz-Rojo J.; Dagliati A.; Daniar M.; Daniel C.; Das P.; Devkota B.; Dionne A.; Duan R.; Dubiel J.; DuVall S. L.; Esteve L.; Estiri H.; Fan S.; Follett R. W.; Ganslandt T.; Garcia-Barrio N.; Garmire L. X.; Gehlenborg N.; Getzen E. J.; Geva A.; Gonzalez T. G.; Gradinger T.; Gramfort A.; Griffier R.; Griffon N.; Grisel O.; Gutierrez-Sacristan A.; Guzzi P. H.; Han L.; Hanauer D. A.; Haverkamp C.; Hazard D. Y.; He B.; Henderson D. W.; Hilka M.; Ho Y. -L.; Holmes J. H.; Honerlaw J. P.; Hong C.; Huling K. M.; Hutch M. R.; Issitt R. W.; Jannot A. S.; Kavuluru R.; Keller M. S.; Kennedy C. J.; Kernan K. F.; Key D. A.; Kirchoff K.; Klann J. G.; Kohane I. S.; Krantz I. D.; Dr D. K.; Krishnamurthy A. K.; L'Yi S.; Le T. T.; Leblanc J.; Lemaitre G.; Lenert L.; Leprovost D.; Liu M.; Loh N. H. W.; Long Q.; Lozano-Zahonero S.; Luo Y.; Lynch K. E.; Mahmood S.; Maidlow S. E.; Makoudjou A.; Makwana S.; Malovini A.; Mandl K. D.; Mao C.; Maram A.; Maripuri M.; Martel P.; Martins M. R.; Marwaha J. S.; Masino A. J.; Mazzitelli M.; Mazzotti D. R.; Mensch A.; Milano M.; Minicucci M. F.; Moal B.; Ahooyi T. M.; Moore J. H.; Moraleda C.; Morris J. S.; Morris M.; Moshal K. L.; Mousavi S.; Mowery D. L.; Murad D. A.; Murphy S. N.; Naughton T. P.; Neto C. T. B.; Neuraz A.; Newburger J.; Ngiam K. Y.; Njoroge W. F. M.; Norman J. B.; Obeid J.; Okoshi M. P.; Olson K. L.; Omenn G. S.; Orlova N.; Ostasiewski B. D.; Palmer N. P.; Paris N.; Patel L. P.; Pedrera-Jimenez M.; Pfaff A. C.; Pfaff E. R.; Pillion D.; Pizzimenti S.; Priya T.; Prokosch H. U.; Prudente R. A.; Prunotto A.; Quiros-Gonzalez V.; Ramoni R. B.; Raskin M.; Rieg S.; Roig-Dominguez G.; Rojo P.; Rubio-Mayo P.; Sacchi P.; Saez C.; Salamanca E.; Samayamuthu M. J.; Sanchez-Pinto L. N.; Sandrin A.; Santhanam N.; Santos J. C. C.; Sanz Vidorreta F. J.; Savino M.; Schriver E. R.; Schubert P.; Schuettler J.; Scudeller L.; Sebire N. J.; Serrano-Balazote P.; Serre P.; Serret-Larmande A.; Shah M.; Abad Z. S. H.; Silvio D.; Sliz P.; Son J.; Sonday C.; South A. M.; Sperotto F.; Spiridou A.; Strasser Z. H.; Tan A. L. M.; Tan B. W. Q.; Tan B. W. L.; Tanni S. E.; Taylor D. M.; Terriza-Torres A. I.; Tibollo V.; Tippmann P.; Toh E. M. S.; Torti C.; Trecarichi E. M.; Vallejos A. K.; Varoquaux G.; Vella M. E.; Verdy G.; Vie J. -J.; Visweswaran S.; Vitacca M.; Wagholikar K. B.; Waitman L. R.; Wang X.; Wassermann D.; Weber G. M.; Wolkewitz M.; Wong S.; Xia Z.; Xiong X.; Ye Y.; Yehya N.; Yuan W.; Zachariasse J. M.; Zahner J. J.; Zambelli A.; Zhang H. G.; Zoller D.; Zuccaro V.; Zucco C. |
| Contributors: | Orieux, A; Ferte, T; Jouhet, V; Aaron, J; Agapito, G; Albayrak, A; Albi, G; Alessiani, M; Alloni, A; Amendola, D; Angoulvant, F; Anthony, L; Aronow, B; Ashraf, F; Atz, A; Avillach, P; Panickan, V; Azevedo, P; Balshi, J; Batugo, A; Beaulieu-Jones, B; Beau-Lieu-Jones, B; Bell, D; Bellasi, A; Bellazzi, R; Benoit, V; Beraghi, M; Bernal-Sobrino, J; Bernaux, M; Bey, R; Bhatnagar, S; Blanco-Martinez, A; Boeker, M; Bonzel, C; Booth, J; Bosari, S; Bourgeois, F; Bradford, R; Brat, G; Breant, S; Brown, N; Bruno, R; Bryant, W; Bucalo, M; Bucholz, E; Burgun, A; Cai, T; Cannataro, M; Carmona, A; Cattelan, A; Caucheteux, C; Champ, J; Chen, K; Chen, J; Chiovato, L; Chiudinelli, L; Cho, K; Cimino, J; Colicchio, T; Cormont, S; Cossin, S; Craig, J; Cruz-Bermudez, J; Cruz-Rojo, J; Dagliati, A; Daniar, M; Daniel, C; Das, P; Devkota, B; Dionne, A; Duan, R; Dubiel, J; Duvall, S; Esteve, L; Estiri, H; Fan, S; Follett, R; Ganslandt, T; Garcia-Barrio, N; Garmire, L; Gehlenborg, N; Getzen, E; Geva, A; Gonzalez, T; Gradinger, T; Gramfort, A; Griffier, R; Griffon, N; Grisel, O; Gutierrez-Sacristan, A; Guzzi, P; Han, L; Hanauer, D; Haverkamp, C; Hazard, D; He, B; Henderson, D; Hilka, M; Ho, Y; Holmes, J |
| Publisher Information: | Public Library of Science; US |
| Publication Year: | 2023 |
| Collection: | Università degli Studi di Milano-Bicocca: BOA (Bicocca Open Archive) |
| Subject Terms: | Adolescent; Adult; Aged; Cohort Studie; COVID-19; Electronic Health Record; Human; Middle Aged; Obesity; Respiratory Distress Syndrome; Retrospective Studie; SARS-CoV-2; Young Adult |
| Description: | Purpose In young adults (18 to 49 years old), investigation of the acute respiratory distress syndrome (ARDS) after severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection has been limited. We evaluated the risk factors and outcomes of ARDS following infection with SARS-CoV-2 in a young adult population. Methods A retrospective cohort study was conducted between January 1st, 2020 and February 28th, 2021 using patient-level electronic health records (EHR), across 241 United States hospitals and 43 European hospitals participating in the Consortium for Clinical Characterization of COVID-19 by EHR (4CE). To identify the risk factors associated with ARDS, we compared young patients with and without ARDS through a federated analysis. We further compared the outcomes between young and old patients with ARDS. Results Among the 75,377 hospitalized patients with positive SARS-CoV-2 PCR, 1001 young adults presented with ARDS (7.8% of young hospitalized adults). Their mortality rate at 90 days was 16.2% and they presented with a similar complication rate for infection than older adults with ARDS. Peptic ulcer disease, paralysis, obesity, congestive heart failure, valvular disease, diabetes, chronic pulmonary disease and liver disease were associated with a higher risk of ARDS. We described a high prevalence of obesity (53%), hypertension (38%-although not significantly associated with ARDS), and diabetes (32%). Conclusion Trough an innovative method, a large international cohort study of young adults developing ARDS after SARS-CoV-2 infection has been gather. It demonstrated the poor outcomes of this population and associated risk factor. |
| Document Type: | article in journal/newspaper |
| File Description: | ELETTRONICO |
| Language: | English |
| Relation: | info:eu-repo/semantics/altIdentifier/pmid/36598895; info:eu-repo/semantics/altIdentifier/wos/WOS:000982954100001; volume:18; issue:1; journal:PLOS ONE; https://hdl.handle.net/10281/527183 |
| DOI: | 10.1371/journal.pone.0266985 |
| Availability: | https://hdl.handle.net/10281/527183; https://doi.org/10.1371/journal.pone.0266985 |
| Rights: | info:eu-repo/semantics/openAccess ; license:Creative Commons ; license uri:http://creativecommons.org/licenses/by/4.0/ |
| Accession Number: | edsbas.AF12D910 |
| Database: | BASE |