| Title: |
Diagnostic accuracy of FET-PET/CT, FDG-PET/CT and diffusion-weighted MRI in detection of nodal metastases in surgically treated endometrial and cervical carcinoma |
| Authors: |
Rockall, AG; Barwick, TD; Wilson, W; Singh, N; Bharwani, N; Sohaib, A; Nobbenhuis, M; Warbey, V; Miquel, M; Koh, D-M; De Paepe, KN; Martin-Hirsch, P; Ghaem-Maghami, S; Fotopoulou, C; Stringfellow, H; Sundar, S; Manchanda, R; Sahdev, A; Hackshaw, A; Cook, GJ; Study Group, M |
| Source: |
Clinical Cancer Research (2021) (In press). |
| Publication Year: |
2021 |
| Collection: |
University College London: UCL Discovery |
| Description: |
PURPOSE:Pre-operative nodal staging is important for planning treatment in cervical cancer (CC) and endometrial cancer (EC) but remains challenging. We compare nodal staging accuracy of {18}^F-ethyl-choline-(FEC)-PET/CT, {18}^F-Fluoro-deoxy-glucose-(FDG)-PET/CT and diffusion-weighted-MRI (DW-MRI) with conventional morphological MRI. Experimental Design: A prospective, multicentre observational study of diagnostic accuracy for nodal metastases was undertaken in 5 gyne-oncology centres. FEC-PET/CT, FDG-PET/CT and DW-MRI were compared to nodal size and morphology on MRI. Reference standard was strictly correlated nodal histology. Eligibility included operable CC stage=>1B1 or EC (grade 3 any stage with myometrial invasion or grade 1-2 stage=>II). RESULTS: Among 162 consenting participants, 136 underwent study DW-MRI and FDG-PET/CT, and 60 underwent FEC-PET/CT. 267 nodal regions in 118 women were strictly correlated at histology (nodal positivity rate 25%). Sensitivity per-patient (n=118) for nodal size, morphology, DW-MRI, FDG- and FEC-PET/CT were 40%*, 53%, 53%, 63%* and 67% for all cases (*p=0.016); 10%, 10%, 20%, 30% and 25% in CC (n=40); 65%, 75%, 70%, 80% and 88% in EC (n=78). FDG-PET/CT outperformed nodal size (p=0.006) and size ratio (p=0.04) for per-region sensitivity. False positive rates were all |
| Document Type: |
article in journal/newspaper |
| File Description: |
text |
| Language: |
English |
| Relation: |
https://discovery.ucl.ac.uk/id/eprint/10134712/ |
| Availability: |
https://discovery.ucl.ac.uk/id/eprint/10134712/1/Rockall_Manchanda_Mapping_2021_ClinCaRes_FEC-PETCT_FDG-PETCT_acccuracy_EC-CaCx.pdf; https://discovery.ucl.ac.uk/id/eprint/10134712/ |
| Rights: |
open |
| Accession Number: |
edsbas.AF19CF61 |
| Database: |
BASE |