| Title: |
P-435: Health-related quality of life in elderly treated hypertensive patients - data from the study on cognition and prognosis in the elderly (SCOPE) |
| Authors: |
Lithell, Hans; DeglInnocenti, Alessio; The S.C.O.P.E. Study team |
| Publisher Information: |
Oxford University Press |
| Publication Year: |
2003 |
| Collection: |
HighWire Press (Stanford University) |
| Subject Terms: |
Abstracts |
| Description: |
The Study on COgnition and Prognosis in the Elderly (SCOPE, n=4,937) assessed the effect of candesartan (Cand) on cardiovascular (CV) events, cognition and dementia in elderly patients with hypertension. Blood pressure (BP) was reduced from 166/90 to 145/80 mmHg in the Cand group and from 167/90 to 149/82 mmHg in the control group. Cand-based treatment, compared with control treatment, reduced non-fatal stroke by 28%, but had no significant effect on the composite primary endpoint (major CV events). This sub-study evaluated the effect on health-related quality of life (HRQL) in total 2,850 patients (mean age 76.4 years). Three validated questionnaires were completed at baseline and during follow-up (mean 3.7 years): the Psychological General Well-Being (PGWB) index, the Subjective Symptom Assessment Profile (SSA-P), and the EuroQoL. ANCOVA was used to test between group differences in change from baseline to last visit, adjusted for baseline value and country. Results are given in the table. HRQL Scores in SCOPE BaselineChangeDifference in ChangeCandControlCandControlMean95% CIPPGWB |
| Document Type: |
text |
| File Description: |
text/html |
| Language: |
English |
| Relation: |
http://ajh.oxfordjournals.org/cgi/content/short/16/S1/195A; http://dx.doi.org/10.1016/S0895-7061(03)00607-1 |
| DOI: |
10.1016/S0895-7061(03)00607-1 |
| Availability: |
http://ajh.oxfordjournals.org/cgi/content/short/16/S1/195A; https://doi.org/10.1016/S0895-7061(03)00607-1 |
| Rights: |
Copyright (C) 2003, American Journal of Hypertension, Ltd. |
| Accession Number: |
edsbas.AFB08A4F |
| Database: |
BASE |