| Title: |
Deletions of the Plasmodium falciparum histidine-rich protein 2/3 genes are common in field isolates from north-eastern Tanzania. |
| Authors: |
Kaaya, Robert D; Kavishe, Reginald A; Tenu, Filemon F; Matowo, Johnson J; Mosha, Franklin W; Drakeley, Chris; Sutherland, Colin J; Beshir, Khalid B |
| Publisher Information: |
Nature Research (part of Springer Nature) |
| Publication Year: |
2022 |
| Collection: |
London School of Hygiene & Tropical Medicine: LSHTM Research Online |
| Description: |
Plasmodium falciparum parasites lacking histidine-rich protein 2 and 3 (pfhrp2/3) genes have been reported in several parts of the world. These deletions are known to compromise the effectiveness of HRP2-based malaria rapid diagnostic tests (HRP2-RDT). The National Malaria Control Programme (NMCP) in Tanzania adopted HRP2-RDTs as a routine tool for malaria diagnosis in 2009 replacing microscopy in many Health facilities. We investigated pfhrp2/3 deletions in 122 samples from two areas with diverse malaria transmission intensities in Northeastern Tanzania. Pfhrp2 deletion was confirmed in 1.6% of samples while pfhrp3 deletion was confirmed in 50% of samples. We did not find parasites with both pfhrp2 and pfhrp3 deletions among our samples. Results from this study highlight the need for systematic surveillance of pfhrp2/3 deletions in Tanzania to understand their prevalence and determine their impact on the performance of mRDT. |
| Document Type: |
article in journal/newspaper |
| File Description: |
text |
| Language: |
English |
| ISSN: |
2045-2322 |
| Relation: |
https://researchonline.lshtm.ac.uk/id/eprint/4665957/1/Deletions%20of%20the%20Plasmodium%20falciparum%20histidine-rich%20protein%2023%20genes%20are%20common%20in%20field%20isolates%20from%20north-eastern%20Tanza.pdf; Kaaya, Robert D; Kavishe, Reginald A; Tenu, Filemon F; Matowo, Johnson J; Mosha, Franklin W; Drakeley, Chris ORCID logo; Sutherland, Colin J ORCID logo; and Beshir, Khalid B ORCID logo (2022) Deletions of the Plasmodium falciparum histidine-rich protein 2/3 genes are common in field isolates from north-eastern Tanzania. Scientific reports, 12 (1). 5802-. ISSN 2045-2322 DOI:10.1038/s41598-022-09878-3 |
| Availability: |
https://researchonline.lshtm.ac.uk/id/eprint/4665957/ |
| Rights: |
cc_by_4 |
| Accession Number: |
edsbas.AFB1305F |
| Database: |
BASE |