| Title: |
Measures of longitudinal immune dysfunction and risk of AIDS and non-AIDS defining malignancies in antiretroviral treated people with human immunodeficiency virus (HIV) / |
| Authors: |
Chammartin, Frédérique; Mocroft, Amanda; Egle, Alexander; Zangerle, Robert; Smith, Colette; Mussini, Cristina; Wit, Ferdinand; Vehreschild, Jörg Janne; d’Arminio Monforte, Antonella; Castagna, Antonella; Bailly, Laurent; Bogner, Johannes; de Wit, Stéphane; Matulionytė, Raimonda; Law, Matthew; Svedhem, Veronica; Tallada, Joan; Garges, Harmony P; Marongiu, Andrea; Borges, Álvaro H; Jaschinski, Nadine; Neesgaard, Bastian; Ryom, Lene; Bucher, Heiner C; Wit, F.; van der Valk, M.; Hillebregt, M.; Petoumenos, K.; Law, M.; Zangerle, R.; Appoyer, H.; Stephan, C.; Bucht, M.; Chkhartishvili, N.; Chokoshvili, O.; d’Arminio Monforte, A.; Rodano, A.; Tavelli, A.; Fanti, I.; Casabona, J.; Miro, J M; Llibre, J M; Riera, A.; Reyes-Urueña, J.; Smith, C.; Lampe, F.; Sönnerborg, A.; Falconer, K.; Svedhem, V.; Günthard, H.; Ledergerber, B.; Bucher, H.; Kusejko, K.; Wasmuth, J C; Rockstroh, J.; Vehreschild, J J; Fätkenheuer, G.; Ryom, L.; Campo, R.; De Wit, S.; Garges, H.; Lundgren, J.; McNicholl, I.; Rooney, J.; Vannappagari, V.; Wandeler, G.; Young, L.; Begovac, J.; Bruguera, A.; Castagna, A.; D’Arminio Monforte, A.; Dedes, N.; Kowalska, J.; Mussini, C.; Necsoi, C.; Peters, L.; Pradier, C.; Raben, D.; Volny Anne, A.; Williams, E D; Mocroft, A.; Neesgaard, B.; Greenberg, L.; Jaschinski, N.; Timiryasova, A.; Bansi-Matharu, L.; Tusch, E.; Bannister, W.; Roen, A.; Byonanebye, D.; Fursa, O.; Pelchen-Matthews, A.; Reekie, J.; Svedhem-Johansson, V.; Van der Valk, M.; Grabmeier-Pfistershammer, K.; Hoy, J.; Bloch, M.; Braun, D.; Calmy, A.; Schüttfort, G.; Youle, M.; Zona, S.; Antinori, A.; Bolokadze, N.; Fontas, E.; Dollet, K.; Schwarze-Zander, C.; Hutchinson, J.; Duvivier, C.; Dragovic, G.; Radoi, R.; Oprea, C.; Vasylyev, M.; Matulionyte, R.; Mulabdic, V.; Marchetti, G.; Kuzovatova, E.; Coppola, N.; Aho, I.; Martini, S.; Harxhi, A.; Wæhre, T.; Pharris, A.; Vassilenko, A.; Bogner, J.; Maagaard, A.; Jablonowska, E.; Elbirt, D.; Marrone, G.; Leen, C.; Wyen, C.; Dahlerup Rasmussen, L.; Hatleberg, C.; Kundro, M.; Dixon Williams, E.; Gallant, J.; Cohen, C.; Dunbar, M.; Marongiu, A.; Mendao, L.; Valdenmaier, O.; Larsen, J F; Gardizi, M.; Elsing, T W; Ramesh Kumar, L.; Shahi, S.; Andersen, K. |
| Source: |
Clinical infectious diseases., Oxford : Oxford University Press, 2024, vol. 78, iss. 4, p. 995-1004. ; ISSN 1058-4838 ; eISSN 1537-6591 |
| Publication Year: |
2023 |
| Collection: |
Vilnius University Virtual Library (VU VL) / Vilniaus universitetas virtuali biblioteka |
| Subject Terms: |
CD4:CD8 ratio; HIV infection; malignancy; observational study; antiretroviral therapy |
| Description: |
Background. Human immunodeficiency virus (HIV) infection leads to chronic immune activation/inflammation that can persist in virally suppressed persons on fully active antiretroviral therapy (ART) and increase risk of malignancies. The prognostic role of low CD4:CD8 ratio and elevated CD8 cell counts on the risk of cancer remains unclear. Methods. We investigated the association of CD4:CD8 ratio on the hazard of non-AIDS defining malignancy (NADM), AIDSdefining malignancy (ADM) and most frequent group of cancers in ART-treated people with HIV (PWH) with a CD4 and CD8 cell counts and viral load measurements at baseline. We developed Cox proportional hazard models with adjustment for known confounders of cancer risk and time-dependent cumulative and lagged exposures of CD4:CD8 ratio to account for timeevolving risk factors and avoid reverse causality. Results. CD4:CD8 ratios below 0.5, compared to above 1.0, were independently associated with a 12-month time-lagged higher risk of ADM and infection-related malignancies (adjusted hazard ratio 2.61 [95% confidence interval {CI }1.10–6.19] and 2.03 [95% CI 1.24–3.33], respectively). CD4 cell counts below 350 cells/μL were associated with an increased risk of NADMs and ADMs, as did infection, smoking, and body mass index-related malignancies. Conclusions. In ART-treated PWH low CD4:CD8 ratios were associated with ADM and infection-related cancers independently from CD4 and CD8 cell counts and may alert clinicians for cancer screening and prevention of NADM. |
| Document Type: |
article in journal/newspaper |
| File Description: |
application/pdf |
| Language: |
English |
| Relation: |
https://epublications.vu.lt/object/elaba:184529566/184529566.pdf; https://repository.vu.lt/VU:ELABAPDB184529566&prefLang=en_US |
| Availability: |
https://repository.vu.lt/VU:ELABAPDB184529566&prefLang=en_US |
| Rights: |
info:eu-repo/semantics/openAccess |
| Accession Number: |
edsbas.AFC04CF0 |
| Database: |
BASE |