| Title: |
Too fast to stay on track? Shorter time to first anti-retroviral regimen is not associated with better retention in care in the French Dat'AIDS cohort. |
| Authors: |
L Cuzin; L Cotte; C Delpierre; C Allavena; M-A Valantin; D Rey; P Delobel; P Pugliese; F Raffi; A Cabié; Dat’AIDS Study group |
| Source: |
PLoS ONE, Vol 14, Iss 9, p e0222067 (2019) |
| Publisher Information: |
Public Library of Science (PLoS) |
| Publication Year: |
2019 |
| Collection: |
Directory of Open Access Journals: DOAJ Articles |
| Subject Terms: |
Medicine; Science |
| Description: |
BACKGROUND:Rapid antiretroviral therapy (ART) initiation has been proven beneficial for patients and the community. We aimed to analyze recent changes in timing of ART initiation in France and consequences of early start. METHODS:We selected from a prospective nationwide cohort, on 12/31/2017, patients with HIV-1 infection diagnosed between 01/01/2010 and 12/31/2015. We described time from (1) diagnosis to first specialized medical encounter, (2) from this encounter to ART initiation, (3) from diagnosis to first undetectable HIV viral load (VL). We analyzed the determinants of measured temporal trends. A multivariate logistic regression was performed to assess characteristics related with 1-year retention in care. RESULTS:In the 7 245 included patients, median time (1) from HIV diagnosis to first medical encounter was 13 (IQR: 6-32) days, (2) to ART initiation was 27 (IQR: 9-91) days, decreasing from 42 (IQR: 13-272) days in 2010 to 18 (IQR: 7-42) in 2015 (p |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| Relation: |
https://doi.org/10.1371/journal.pone.0222067; https://doaj.org/toc/1932-6203; https://doaj.org/article/5a15d7768c1149d5b82d5760982b720b |
| DOI: |
10.1371/journal.pone.0222067 |
| Availability: |
https://doi.org/10.1371/journal.pone.0222067; https://doaj.org/article/5a15d7768c1149d5b82d5760982b720b |
| Accession Number: |
edsbas.AFD199C8 |
| Database: |
BASE |