| Title: |
Obesity and overweight are linked to increased sodium-glucose cotransporter 1 and glucose transporter 5 levels in duodenum |
| Authors: |
Fiorentino T. V.; De Vito F.; Suraci E.; Marasco R.; Hribal M. L.; Luzza F.; Sesti G. |
| Contributors: |
Fiorentino, T. V.; De Vito, F.; Suraci, E.; Marasco, R.; Hribal, M. L.; Luzza, F.; Sesti, G. |
| Publication Year: |
2023 |
| Collection: |
Sapienza Università di Roma: CINECA IRIS |
| Subject Terms: |
Obesity; overweight; sodium-glucose cotransporter 1; duodenum |
| Description: |
Objective: Prior evidence indicates that individuals with obesity have an accelerated intestinal glucose absorption. This cross-sectional study evaluated whether those with overweight or obesity display higher duodenal protein levels of the glucose carriers sodium-glucose cotransporter 1 (SGLT-1), glucose transporter 2 (GLUT-2), and glucose transporter 5 (GLUT-5). Methods: SGLT-1, GLUT-2, and GLUT-5 protein levels were assessed on duodenal mucosa biopsies of 52 individuals without diabetes categorized on the basis of their BMI as lean, with overweight, or with obesity. Results: Individuals with overweight and obesity exhibited progressively increased duodenal protein levels of SGLT-1 and GLUT-5 as compared with the lean group. Conversely, no differences in duodenal GLUT-2 abundance were found among the three groups. Univariate analysis showed that SGLT-1 and GLUT-5 protein levels were positively correlated with BMI, waist circumference, 1-hour post-load glucose, fasting and post-load insulin, and insulin secretion and resistance levels. Furthermore, a positive relationship was detected between intestinal GLUT-5 levels and serum uric acid concentrations, a product of fructose metabolism known to be involved in the pathogenesis of obesity and its complications. Conclusions: Individuals with overweight and obesity display enhanced duodenal SGLT-1 and GLUT-5 abundance, which correlates with increased postprandial glucose concentrations, insulin resistance, and hyperinsulinemia. |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| Relation: |
info:eu-repo/semantics/altIdentifier/pmid/36746764; info:eu-repo/semantics/altIdentifier/wos/WOS:000928807900001; volume:31; issue:3; firstpage:724; lastpage:731; numberofpages:8; journal:OBESITY; https://hdl.handle.net/11573/1671233 |
| DOI: |
10.1002/oby.23653 |
| Availability: |
https://hdl.handle.net/11573/1671233; https://doi.org/10.1002/oby.23653 |
| Rights: |
info:eu-repo/semantics/closedAccess ; license:Tutti i diritti riservati (All rights reserved) ; license uri:iris.PRI00 |
| Accession Number: |
edsbas.AFE94D5F |
| Database: |
BASE |