| Title: |
Dynamic nuclear polarization of biocompatible 13 C-enriched carbonates for in vivo pH imaging |
| Authors: |
Korenchan, DE; Flavell, RR; Baligand, C; Sriram, R; Neumann, K; Sukumar, S; VanBrocklin, H; Vigneron, DB; Wilson, DM; Kurhanewicz, J |
| Source: |
Chemical Communications, vol 52, iss 14 |
| Publisher Information: |
eScholarship, University of California |
| Publication Year: |
2016 |
| Collection: |
University of California: eScholarship |
| Subject Terms: |
Engineering; Chemical Sciences; Urologic Diseases; Aging; Biomedical Imaging; Prostate Cancer; Cancer; Biocompatible Materials; Carbon Isotopes; Carbon-13 Magnetic Resonance Spectroscopy; Hydrogen-Ion Concentration; Organic Chemistry |
| Time: |
3030 - 3033 |
| Description: |
A hyperpolarization technique using carbonate precursors of biocompatible molecules was found to yield high concentrations of hyperpolarized (13)C bicarbonate in solution. This approach enabled large signal gains for low-toxicity hyperpolarized (13)C pH imaging in a phantom and in vivo in a murine model of prostate cancer. |
| Document Type: |
article in journal/newspaper |
| File Description: |
application/pdf |
| Language: |
unknown |
| Relation: |
qt5wn5j7g2; https://escholarship.org/uc/item/5wn5j7g2; https://escholarship.org/content/qt5wn5j7g2/qt5wn5j7g2.pdf |
| DOI: |
10.1039/c5cc09724j |
| Availability: |
https://escholarship.org/uc/item/5wn5j7g2; https://escholarship.org/content/qt5wn5j7g2/qt5wn5j7g2.pdf; https://doi.org/10.1039/c5cc09724j |
| Rights: |
public |
| Accession Number: |
edsbas.AFFC411 |
| Database: |
BASE |