| Contributors: |
Gorini, G.; Puliti, D.; Picozzi, G.; Giovannoli, J.; Veronesi, G.; Pistelli, F.; Senore, C.; Tessa, C.; Cavigli, E.; Bisanzi, S.; Dieci, E.; Muriana, P.; Deliperi, A.; Romano, E.; Piccinelli, C.; Vivani, P.; Paci, E.; Carrozzi, L.; Mascalchi, M.; Diciotti, S.; Zucchetti, E.; Pugni, C.; Nolli, C.; Mondino, L.; Massi, M.; Guerra, P.; Giraudi, E.; Fracchia, A.; Durando, G.; Di Valente, F.; De Ambrogio, C.; D'Agostino, F.; Cernigliaro, R.; Cataldi, P.; Cannatelli, A.; Bianchi, S.; Rossi, P. R.; Araldi, M.; Sassi, G.; Puccetti, L.; Romagnani, L.; Calistri, B.; Biancalani, N.; Guerrini, A.; Di Francesco, M.; Fioriti, M.; Fallani, L.; Taddei, M.; Di Natale, A.; Manfredi, A.; Gai, P.; Galli, V.; Guidoni, G.; Fanini, C.; Piccioni, P.; Beatrice, F.; Anglesio, S.; Gollini, P.; Novello, S.; Albera, R.; Vavala, T.; Di Chio, A.; Faletti, R.; Fonio, P.; Ghio, D.; Viscardi, S.; De Santis, S.; Coltelli, M.; Stellati, I.; Zanetti, M.; Lupetti, L.; Marchi, G.; Coltelli, N.; Vivaldi, B.; Guglielmi, G.; Casto, E.; Paoli, S.; Bessi, V.; Falaschi, Z.; Romei, C.; Cruschelli, C.; Orlandi, I.; Bartolucci, M.; Miele, V.; Luvara, S.; Moroni, C.; Bindi, A.; Gozzi, L.; Smorchkova, O.; Checcacci, S.; Vannacci, A.; Ferrari, K.; Cozzi, D.; Mantellini, P.; Masala, G.; Visioli, C.; Viti, J.; Sani, C.; Carreras, G. |
| Description: |
Background: The CCM-ITALUNG2 pilot was implemented to evaluate the feasibility of an organized lung cancer (LC) screening programme in five Italian centres. Methods: The screening pathway included invitation, recruitment, referral to Smoking Cessation Services (SCSs), and use of the Lung-RADS score for low-dose CT reading. Dedicated screening operators followed up participants from recruitment through the clinical follow-up established by multidisciplinary teams. Eligibility criteria included age 55–75years, ever-smokers with ≥ 25 pack-years; quit within the past 10 years. Baseline round results are presented. Results: From November 2022 to May 2024, 1,144 of the 1,971 invited individuals (58.0%) were recruited following different strategies including in-person invitation by general practitioners (GPs; 356 subjects, 31.9%) or other healthcare personnel (18.1%), self-presentation (36.3%), and phone invitation using GPs’ patient lists (13.7%). Among current smokers, 38.5% accepted referral to SCSs. Eighteen subjects (77.8% in stage I–II) were diagnosed with LC (prevalent LC rate 1.57%). The mean time to surgery was 147days (standard deviation 73); the false-positive rate was 1.38% (15/1,085). Conclusions: By utilizing different organizational models, the pilot was tailored to the specific characteristics of each centre. Phone invitations from GPs’ patient lists, in-person invitations by GPs and other healthcare personnel, and self-presentation might enhance equity of access in comparison with self-referral only. Dedicated screening operators, the use of the Lung-RADS scoring system, and a structured clinical follow-up supported participants throughout the screening pathway. Delivering brief advice for smoking cessation during recruitment and offering SCS referral were feasible within the screening pathway. |