| Title: |
New data and an old puzzle: the negative association between schizophrenia and rheumatoid arthritis |
| Authors: |
Lee, S. Hong; Byrne, Enda M.; Hultman, Christina M.; Kähler, Anna; Vinkhuyzen, Anna Ae; Ripke, Stephan; Andreassen, Ole A.; Frisell, Thomas; Gusev, Alexander; Hu, Xinli; Karlsson, Robert; Mantzioris, Vasilis X.; McGrath, John J.; Mehta, Divya; Stahl, Eli A.; Zhao, Qiongyi; Kendler, Kenneth S.; Sullivan, Patrick F.; Price, Alkes L.; O'Donovan, Michael; Okada, Yukinori; Mowry, Bryan J.; Raychaudhuri, Soumya; Wray, Naomi R.; Byerley, William; Cahn, Wiepke; Cantor, Rita M.; Cichon, Sven; Cormican, Paul; Curtis, David; Djurovic, Srdjan; Escott-Price, Valentina; Gejman, Pablo V.; Georgieva, Lyudmila; Giegling, Ina; Hansen, Thomas F.; Ingason, Andrés; Kim, Yunjung; Konte, Bettina; Lee, Phil H.; McIntosh, Andrew; McQuillin, Andrew; Morris, Derek W.; Nöthen, Markus M.; O'Dushlaine, Colm; Olincy, Ann; Olsen, Line; Pato, Carlos N.; Pato, Michele T.; Pickard, Benjamin S.; Posthuma, Danielle; Rasmussen, Henrik B.; Rietschel, Marcella; Rujescu, Dan; Schulze, Thomas G.; Silverman, Jeremy M.; Thirumalai, Srinivasa; Werge, Thomas; Agartz, Ingrid; Amin, Farooq; Azevedo, Maria H.; Bass, Nicholas; Black, Donald W.; Blackwood, Douglas H.R.; Bruggeman, Richard; Buccola, Nancy G.; Choudhury, Khalid; Cloninger, Robert C.; Corvin, Aiden; Craddock, Nicholas; Daly, Mark J.; Datta, Susmita; Donohoe, Gary J.; Duan, Jubao; Dudbridge, Frank; Fanous, Ayman; Freedman, Robert; Freimer, Nelson B.; Friedl, Marion; Gill, Michael; Gurling, Hugh; De Haan, Lieuwe; Hamshere, Marian L.; Hartmann, Annette M.; Holmans, Peter A.; Kahn, René S.; Keller, Matthew C.; Kenny, Elaine; Kirov, George K.; Krabbendam, Lydia; Krasucki, Robert; Lawrence, Jacob; Lencz, Todd; Levinson, Douglas F.; Lieberman, Jeffrey A.; Lin, Dan-Yu; Linszen, Don H.; Magnusson, Patrik Ke; Maier, Wolfgang; Malhotra, Anil K.; Mattheisen, Manuel; Mattingsdal, Morten; McCarroll, Steven A.; Medeiros, Helena; Melle, Ingrid; Milanova, Vihra; Myin-Germeys, Inez; Neale, Benjamin M.; Ophoff, Roel A.; Owen, Michael J.; Pimm, Jonathan; Purcell, Shaun M.; Puri, Vinay; Quested, Digby J.; Rossin, Lizzy; Ruderfer, Douglas; Sanders, Alan R.; Shi, Jianxin; Sklar, Pamela; St Clair, David; Scott Stroup, T.; Van Os, Jim; Visscher, Peter M.; Wiersma, Durk; Zammit, Stanley; Louis Bridges, S.; Choi, Hyon K.; Coenen, Marieke Jh; de Vries, Niek; Dieud, Philippe; Greenberg, Jeffrey D.; Huizinga, Tom Wj; Padyukov, Leonid; Siminovitch, Katherine A.; Tak, Paul P.; Worthington, Jane; De Jager, Philip L.; Denny, Joshua C.; Gregersen, Peter K.; Klareskog, Lars; Mariette, Xavier; Plenge, Robert M.; van Laar, Mart; van Riel, Piet |
| Source: |
ISSN:0300-5771 ; ISSN:1464-3685 ; International Journal of Epidemiology, vol. 44 (5), Art.No. dyv136, (1706-1721. |
| Publisher Information: |
Oxford University Press |
| Publication Year: |
2015 |
| Subject Terms: |
Science & Technology; Life Sciences & Biomedicine; Public; Environmental & Occupational Health; Schizophrenia; rheumatoid arthritis; genetic relationship; pleiotropy; GENOME-WIDE ASSOCIATION; AUTOIMMUNE-DISEASES; RISK LOCI; VITAMIN-D; BIPOLAR DISORDER; COMMON VARIANTS; ANTIBODY STATUS; FAMILIAL RISKS; IMMUNE-SYSTEM; SUSCEPTIBILITY; Adolescent; Adult; Arthritis; Rheumatoid; Cohort Studies; Cross-Sectional Studies; Female; Gene-Environment Interaction; Genetic Predisposition to Disease; Genetic Variation; Genome-Wide Association Study; Humans |
| Description: |
A long-standing epidemiological puzzle is the reduced rate of rheumatoid arthritis (RA) in those with schizophrenia (SZ) and vice versa. Traditional epidemiological approaches to determine if this negative association is underpinned by genetic factors would test for reduced rates of one disorder in relatives of the other, but sufficiently powered data sets are difficult to achieve. The genomics era presents an alternative paradigm for investigating the genetic relationship between two uncommon disorders. ; sponsorship: This work was supported by the Australian Research Council [grant number DE130100614 to S.H.L.], the National Health and Medical Research Council [grant numbers 613602, 1078901 to N.R.W; 1047956 to N.R.W., S.H.L. and B.J.M., 1053639 to E.M.B]; the Arthritis Foundation to S.R., the Doris Duke Foundation to S.R.; the National Institutes of Health [grant numbers 1R01AR063759-01A1, 1U01HG0070033, 5U01GM092691-04 to S.R.; R01 MH077139 for the Sweden SZ Study to P.F.S.]. The Swedish SZ study was also funded by the Karolinska Institutet, Karolinska University Hospital, and the Swedish Research Council. The RA dataset from Vanderbilt University Medical Center's BioVU is supported by institutional funding and by the Vanderbilt CTSA grant ULTR000445 from NCATS/NIH. Other funding acknowledgements can be found in the primary publications from each study, as references. Statistical analyses were carried out on the Genetic Cluster Computer (http://www.geneticcluster.org) hosted by SURFsara, and financially supported by The Netherlands Scientific Organization (NWO 480-05-003) along with a supplement from the Dutch Brain Foundation and the VU University Amsterdam. (Australian Research Council|DE130100614, National Health and Medical Research Council|613602, National Health and Medical Research Council|1078901, National Health and Medical Research Council|1047956, National Health and Medical Research Council|1053639, Arthritis Foundation, Doris Duke Foundation, National Institutes of Health|1R01AR063759-01A1, ... |
| Document Type: |
article in journal/newspaper |
| File Description: |
application/pdf |
| Language: |
English |
| Relation: |
https://lirias.kuleuven.be/handle/123456789/514357; https://doi.org/10.1093/ije/dyv136; https://pubmed.ncbi.nlm.nih.gov/26286434 |
| DOI: |
10.1093/ije/dyv136 |
| Availability: |
https://lirias.kuleuven.be/handle/123456789/514357; https://lirias.kuleuven.be/retrieve/57dc65b7-a606-4df1-9c68-bc5ab44eeca7; https://doi.org/10.1093/ije/dyv136; https://pubmed.ncbi.nlm.nih.gov/26286434 |
| Rights: |
info:eu-repo/semantics/openAccess ; public |
| Accession Number: |
edsbas.B028B79A |
| Database: |
BASE |