| Title: |
Cognitive rehabilitation and aerobic exercise for cognitive impairment in people with progressive multiple sclerosis (CogEx): a randomised, blinded, sham-controlled trial |
| Authors: |
Feinstein, A; Amato, MP; Brichetto, G; Chataway, J; Chiaravalloti, ND; Cutter, G; Dalgas, U; DeLuca, J; Farrell, R; Feys, P; Filippi, M; Freeman, J; Inglese, M; Meza, C; Motl, RW; Rocca, MA; Sandroff, BM; Salter, A; Pietrusz, A; Tacchino, A; Smith, A; Michelsen, AS; Kristin, A; Bichler, B; Truax, B; Vizzino, C; Jones, CD; Holme, C; Smith, C; Keytsman, C; Pollio, C; Cole, C; Niccolai, C; Cordani, C; Colombo, E; Pelosin, E; Vanzeir, E; Vannetti, F; Gerli, F; Maranta, F; Riccitelli, G; Pasquini, G; Wilkinson, H; Mosca, I; Braisher, J; Baird, J; Podda, J; Morecraft, J; Lenaerts, J; Puopolo, J; Algie, K; Kenton, L; Toll, L; Madsen, LT; Knevels, L; Lee, L; Pedullà, L; Cellerino, M; Braisher, M; Jørgensen, M-LK; Pardini, M; Sibilia, M; Nabarro, M; Diedmann, MD; DiBenedetto, M; Curran, M; Koch, M; D'Hooge, M; Moore, N; Weerdt, ND; Preziosa, P; Pajak, P; Silic, P; Walters, RB; Finegan, R; Veldkamp, R; Hernandez, R; Donnee, R; Casagrande, S; Lancia, S; Bella, SD; Vandecasteele, S; Vandael, V |
| Publisher Information: |
Elsevier BV; England |
| Publication Year: |
2023 |
| Collection: |
PEARL (Plymouth Electronic Archiv & ResearchLibrary, Plymouth University) |
| Subject Terms: |
Humans; Female; Male; Cognitive Training; Multiple Sclerosis; Exercise; Exercise Therapy; Cognitive Dysfunction |
| Description: |
Background Cognitive dysfunction in people with relapsing-remitting multiple sclerosis can improve with cognitive rehabilitation or exercise. Similar effects have not been clearly shown in people with progressive multiple sclerosis. We aimed to investigate the individual and synergistic effects of cognitive rehabilitation and exercise in patients with progressive multiple sclerosis. Methods CogEx was a randomised, sham-controlled trial completed in 11 hospital clinics, universities, and rehabilitation centres in Belgium, Canada, Denmark, Italy, UK, and USA. Patients with progressive multiple sclerosis were eligible for inclusion if they were aged 25–65 years and had an Expanded Disability Status Scale (EDSS) score of less than 7. All had impaired processing speed defined as a performance of 1·282 SD or greater below normative data on the Symbol Digit modalities Tests (SDMT). Participants were randomly assigned (1:1:1:1), using an interactive web-response system accessed online from each centre, to cognitive rehabilitation plus exercise, cognitive rehabilitation plus sham exercise, exercise plus sham cognitive rehabilitation, or sham exercise plus sham cognitive rehabilitation. The study statistician created the randomisation sequence that was stratified by centre. Participants, outcome assessors, and investigators were blinded to group allocation. The study statistician was masked to treatment during analysis only. Interventions were conducted two times per week for 12 weeks: cognitive rehabilitation used an individualised, computer-based, incremental approach to improve processing speed; sham cognitive rehabilitation consisted of internet training provided individually; the exercise intervention involved individualised aerobic training using a recumbent arm–leg stepper; and the sham exercise involved stretching and balance tasks without inducing cardiovascular strain. The primary outcome measure was processing speed measured by SDMT at 12 weeks; least squares mean differences were compared between groups using ... |
| Document Type: |
article in journal/newspaper |
| File Description: |
912-924; Print; application/pdf |
| Language: |
English |
| ISSN: |
1474-4422; 1474-4465 |
| Relation: |
E-ISSN:1474-4465; https://pearl.plymouth.ac.uk/handle/10026.1/21468 |
| DOI: |
10.1016/s1474-4422(23)00280-6 |
| Availability: |
https://pearl.plymouth.ac.uk/handle/10026.1/21468; https://doi.org/10.1016/s1474-4422(23)00280-6 |
| Accession Number: |
edsbas.B0632A2 |
| Database: |
BASE |