| Title: |
Cardiovascular End Points and Mortality Are Not Closer Associated With Central Than Peripheral Pulsatile Blood Pressure Components |
| Authors: |
Huang, Qi-Fang; Aparicio, Lucas S.; Thijs, Lutgarde; Wei, Fang-Fei; Melgarejo, Jesus D.; Cheng, Yi-Bang; Sheng, Chang-Sheng; Yang, Wen-Yi; Gilis-Malinowska, Natasza; Boggia, José; Niiranen, Teemu J.; Wojciechowska, Wiktoria; Stolarz-Skrzypek, Katarzyna; Barochiner, Jessica; Ackermann, Daniel; Tikhonoff, Valérie; Ponte, Belen; Pruijm, Menno; Casiglia, Edoardo; Narkiewicz, Krzysztof; Filipovský, Jan; Czarnecka, Danuta; Kawecka-Jaszcz, Kalina; Jula, Antti M.; Bochud, Murielle; Vanassche, Thomas; Verhamme, Peter; Struijker-Boudier, Harry A.J.; Wang, Ji-Guang; Zhang, Zhen-Yu; Li, Yan; Staessen, Jan A.; Aparicio, LS; Barochiner, J; Thijs, L; Staessen, JA; Wei, FF; Yang, WY; Zhang, ZY; Cheng, YB; Guo, QH; Huang, JF; Huang, QF; Li, Y; Sheng, CS; Wang, JG; Filipovský, J; Seidlerová, J; Juhanoja, EP; Jula, AM |
| Source: |
Hypertension ; volume 76, issue 2, page 350-358 ; ISSN 0194-911X 1524-4563 |
| Publisher Information: |
Ovid Technologies (Wolters Kluwer Health) |
| Publication Year: |
2020 |
| Description: |
Pulsatile blood pressure (BP) confers cardiovascular risk. Whether associations of cardiovascular end points are tighter for central systolic BP (cSBP) than peripheral systolic BP (pSBP) or central pulse pressure (cPP) than peripheral pulse pressure (pPP) is uncertain. Among 5608 participants (54.1% women; mean age, 54.2 years) enrolled in nine studies, median follow-up was 4.1 years. cSBP and cPP, estimated tonometrically from the radial waveform, averaged 123.7 and 42.5 mm Hg, and pSBP and pPP 134.1 and 53.9 mm Hg. The primary composite cardiovascular end point occurred in 255 participants (4.5%). Across fourths of the cPP distribution, rates increased exponentially (4.1, 5.0, 7.3, and 22.0 per 1000 person-years) with comparable estimates for cSBP, pSBP, and pPP. The multivariable-adjusted hazard ratios, expressing the risk per 1-SD increment in BP, were 1.50 (95% CI, 1.33–1.70) for cSBP, 1.36 (95% CI, 1.19–1.54) for cPP, 1.49 (95% CI, 1.33–1.67) for pSBP, and 1.34 (95% CI, 1.19–1.51) for pPP ( P |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| DOI: |
10.1161/hypertensionaha.120.14787 |
| DOI: |
10.1161/HYPERTENSIONAHA.120.14787 |
| Availability: |
https://doi.org/10.1161/hypertensionaha.120.14787; https://www.ahajournals.org/doi/full/10.1161/HYPERTENSIONAHA.120.14787 |
| Accession Number: |
edsbas.B0697CF3 |
| Database: |
BASE |